1.
Bioorg Med Chem
; 16(21): 9471-86, 2008 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-18842420
ABSTRACT
Several BACE-1 inhibitors with low nanomolar level activities, encompassing a statine-based core structure with phenyloxymethyl- and benzyloxymethyl residues in the P1 position, are presented. The novel P1 modification introduced to allow the facile exploration of the S1 binding pocket of BACE-1, delivered highly promising inhibitors.