ABSTRACT
As part of the studies on Boron Neutron Capture Therapy at the University of Mainz, Germany, a clinical trial has been started in which, four patients suffering from liver metastases of colorectal carcinoma have been enrolled. Specimens of blood and healthy tissue samples taken from the patients were measured at the PGAA facilities at the HFR in Petten, The Netherlands, and at the FRM II in Munich, Germany. From the measured boron concentrations, pharmacokinetic curves and blood-to-tissue concentration ratios were produced.
Subject(s)
Boron/metabolism , Colorectal Neoplasms/pathology , Liver Neoplasms/secondary , Boron/blood , Colorectal Neoplasms/blood , Humans , Liver Neoplasms/blood , Liver Neoplasms/surgeryABSTRACT
At the boron neutron capture therapy (BNCT) facility in Petten, the Netherlands, (10)B concentrations in biological materials are measured with the prompt gamma ray analyses facility that is calibrated using certified (10)B solutions ranging from 0 to 210 ppm. For this study, newly certified (10)B solutions ranging up to 1972 ppm are added. MCNP simulations of the setup range to 5000 ppm. A second order polynomial (as already used) will fit (10)B-concentrations less than 300 ppm. Above 300 ppm a fitted third order polynomial is needed to describe the calibration curve accurately.
Subject(s)
Boron Neutron Capture Therapy/standards , Boron/analysis , Spectrometry, Gamma/standards , Boron/therapeutic use , Boron Neutron Capture Therapy/instrumentation , Boron Neutron Capture Therapy/statistics & numerical data , Facility Design and Construction , Gamma Rays/therapeutic use , Humans , Isotopes/analysis , Isotopes/therapeutic use , Models, Statistical , Monte Carlo Method , Neoplasms/metabolism , Neoplasms/radiotherapy , Netherlands , Nuclear Reactors , Reference Standards , Spectrometry, Gamma/instrumentation , Spectrometry, Gamma/statistics & numerical data , Tissue DistributionABSTRACT
The purpose of this study was twofold: first, to assess the feasibility of conducting speech conditioning sessions within a preschool classroom, and second, to examine the process of transfer of learned verbalizations from those sessions to classroom free time. The results indicated that the former was not only feasible but effective. A nonverbal boy, enrolled in a special education preschool, was taught to imitate reliably six words in 46 15-minute sessions. Furthermore, the child's use of spontaneous whole words during the rest of the classroom day seemed to be responsive to the contingencies of the speech sessions.
