ABSTRACT
This paper presents the synthesis of some tetrazolium salts and metal complexes combinations, which are derived from aromatic and heterocyclic formazans. Elemental quantitative analyses and spectral data confirmed the structure of the new synthesized compounds. The new synthesized compounds were submitted to microbiological tests.
Subject(s)
Anti-Infective Agents/chemical synthesis , Formazans/chemical synthesis , Tetrazolium Salts/chemical synthesis , Anti-Bacterial Agents , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Bacteria/drug effects , Candida albicans/drug effects , Chemical Phenomena , Chemistry, Physical , Formazans/chemistry , Formazans/pharmacology , Microbial Sensitivity Tests/statistics & numerical data , Tetrazolium Salts/chemistry , Tetrazolium Salts/pharmacologyABSTRACT
The paper presents a synthesis of six new Mannich bases, five hydrazones derived from 1-piperidino-methyl-5-R-isatin and three copper complex compounds of 3-(3'-R-phenyl-pyridazinil-hydrazone)-indoline-2-ones (R=H, CH3, OCH3). The structure of the new compounds was confirmed by the results of the elementary and spectral analysis. Pharmacodynamic studies indicated that copper complex compounds present effective biological properties. Thus, it can be seen that the experimental carrageenan-induced inflammatory oedema was 58.3% inhibited by the complex V (R=CH3) after oral administration. Antimicrobial tests revealed that only compound V (R=OCH3) shows a moderate antimicrobial activity against the gram-positive and gram-negative bacteria, used in the test.
Subject(s)
Hydrazones/pharmacology , Isatin/analogs & derivatives , Mannich Bases/pharmacology , Animals , Anti-Bacterial Agents , Anti-Infective Agents/pharmacology , Anti-Inflammatory Agents/therapeutic use , Bacteria/drug effects , Candida albicans/drug effects , Carrageenan , Drug Evaluation, Preclinical , Hydrazones/therapeutic use , Inflammation/chemically induced , Inflammation/drug therapy , Isatin/pharmacology , Isatin/therapeutic use , Mannich Bases/therapeutic use , Mice , Microbial Sensitivity Tests , Structure-Activity RelationshipABSTRACT
This paper presents a synthesis about some hydrazones, formazans and copper's complexes combinations. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR spectral analysis. The antimicrobial and antiinflammatory activities were investigated.
