[Estimation of the incidence of digestive tract cancers by region]. / Estimation de l'incidence des cancers du tube digestif par région.

OBJECTIVES: Information about the incidence of cancer in the national territory is a necessity for decision makers in public health. The aim of this study was to estimate for the first time the incidence of digestive tract cancers in each region of France in 1992 as well as trends in incidence between 1985 and 1995. METHODS: The incidence/mortality ratio established by sex, by age group and by localization in the departments covered by a cancer registry was applied to the mortality of each region studied. The mortality data were fit by applying a log linear model. RESULTS: The highest incidence rates of esophageal cancer were found in the North, in Brittany, Normandy and Picardy. The lowest rates were found in the regions of Midi-Pyrénées, Languedoc-Roussillon, Provence-Alpes-Côte d'Azur, Aquitaine and Poitou-Charentes. The incidence of this cancer decreased slightly between 1985 and 1995. Brittany and Normandy were also high risk regions for gastric cancer, while Provence-Alpes-Côte d'Azur, Midi-Pyrénées and Poitou-Charente were low risk regions. The incidence of gastric cancer also decreased more markedly than that of esophageal cancer. Colorectal cancer was more frequent in Alsace, Lorraine and in the North, it was less common in Provence-Alpes-Côte d'Azur, Midi-Pyrénées and Franche-Comté. The incidence of this cancer increased little over the 10 years of the study. CONCLUSION: There are regional disparities in the incidence and trends of digestive cancer incidence. These are more marked for esophageal cancer and gastric cancer than for colorectal cancer. The data supplied are of use both in the planning of health care and in the study of the causes or the prevention of digestive cancers.

Association between calcium ingested from drinking water and femoral bone density in elderly women: evidence from the EPIDOS cohort.

Although the main source of dietary calcium is dairy products, the calcium contained in mineral water, which is as available as that of milk, could provide a valuable source of calcium. We analyzed the data from the EPIDOS multicenter study to evaluate the relationship between both dietary calcium and that supplied by drinking water and bone density measured at the femoral neck by dual-energy X-ray absorptiometry. The study included 4434 women over 75 years of age who had not received any treatment likely to interfere with calcium metabolism. A significant correlation was found between total calcium intake and bone density at the femoral neck (r = 0.10, p < 0. 001). After adjustment for the main variables influencing bone density, an increase of 100 mg/day in calcium from drinking water was associated to a 0.5% increase in femoral bone density, while a similar increase in dietary calcium from other sources only led to a 0.2% increase; however, this difference was not significant. The consumption of calcium-rich mineral water may be of interest, especially in older women who consume little calcium from dairy products.

Road accident statistics: discrepancies between police and hospital data in a French island.

In most developed countries, information on road crashes are routinely collected by the police. However, comparison of police records and hospital data underlines a deficit of the number of road accidents in the routine statistics. In La Réunion, a French overseas dependency, an epidemiological study of injuries leading to hospitalisation or deaths has been performed from June 1993 to June 1994. The comparison between hospital data and police records showed that only 37.3% of non-fatally traffic-injured in-patients were recorded by the police. Length of stay in hospital, physician in charge of the first aid, urban place of the crash, type of vehicle involved, day and time of the crash and blood alcohol concentration were significantly associated with the presence in the police file. Police overestimated the severity of the injuries. Police notified 100 deaths on the 115 counted by the study. In France, non-fatally traffic-injured should be followed 30 days to improve quality of police death records. A capture-recapture method was used to estimate the total number of injured people. The capture-recapture method consists in merging information from several sources of notification to determine the real number of cases in the population and the exhaustivity of each source. We estimated that 346 subjects were injured in one month whereas police data recorded only 87 and hospital data 137. This method seems interesting to use in routine after validation when unique personal identifiers are available.

[Arterial hypertension and socioeconomic status in a representative population of French railway drivers]. / Hypertension artérielle statut social et environnement dans une population de conducteurs de trains français.

UNLABELLED: High blood pressure (HDP) is known as a cardiovascular risk factor depending both on environmental and socio-economic factors. METHODS: From October 1993 to october 1994 a cross sectional study was carried out among 1,855 French railway drivers (FRD) representative of the 17,432 males FRD, aged 25 to 54 years. Age, weight, height, hip and waist, smoking, living area, type of train they drove (goods, suburban, TGV, inter-city trains), their grade (3 grades) were recorded. HBP corresponds to systolic blood pressure (BP) 160 mmHg or diastolic BP > or = 95 mmHg or to normal BP under antihypertensive medication. The analysis was carried out according to 2 age classes: 20-36/37-54 years. RESULTS: In our sample 8.5% of FRD suffered from HBP, 3.5% in the younger class, and 13.5% in the other one. Using univariate analysis, among the oldest, subjects with lower grades suffered more often from HBP (19%). Paris area was more often related to HBP for the 20-36 years (6.7%). This was the case for the oldest living in Paris area (19.7%), and the North East (15.2%). Subjects with central obesity (19.9 vs 6%), and hyperlipidemic FRD (20.9 vs 10.9%) were more often related to HBP in the 35-54 years group Whatever the type of train they drove no difference was found. In multivariate analysis, (stepwise logistic regression BMDP LR) independent HBP factors are: age OR 3.4 IC 1.9-5.9 (20-36 vs 37-54), central obesity OR 1.7 IC 1.1-2.6, tobacco consumption OR 2.1 IC 1.2-3.5 (smokers vs non smokers), ex-smokers: OR 2.3 IC 1.3-3.9 (Ex-smokers vs non smokers), living area (all regions vs South East in the Mediterranean border). Nevertheless, grades and type of train they drove were not independent factors. CONCLUSION: These results show the determining part played by environmental factors: age, central obesity, living area and tobacco consumption in the determinism of HBP in professional background: these factors can account for the difference observed in professional factor (grade).

A comparative survey of antidepressant drug prescribing habits of general practitioners and psychiatrists.

OBJECTIVE: Clinical experience suggests important differences in prescriptions from general practitioners and specialists. This study investigated these differences and their determinants for antidepressant drug prescribing intentions by general practitioners and psychiatrists in France. STUDY PARTICIPANTS: In May 1995, a mail questionnaire was sent to a representative panel of 300 general practitioners and 100 psychiatrists from the Midi-Pyrenees area (South West France). Two types of questions were asked: the first concerned the type of antidepressants prescribed according to the characteristics of depression ('severe', with insomnia, anxiety, etc.) and the second, the factors influencing prescriptions (personal experience, adverse effects, clinical trials, cost, etc.). RESULTS: 151 general practitioners (51%) and 63 psychiatrists (63%) answered the questionnaire. The analysis showed large differences between the two groups of physicians. Serotoninergic antidepressants were reported to be the most common first-line drugs of choice in both groups of practitioners. General practitioners claimed to prescribe serotoninergic antidepressants more frequently than psychiatrists (74 vs 59%, p < 0.05). Psychiatrists were reported to prescribe higher dosages of antidepressants than general practitioners in 'severe' depression (109.7 vs 85.6mg daily, p < 0.001). General practitioners were reported to prescribe anxiolytic agents more frequently than psychiatrists (73 vs 54%, p < 0.05), and neuroleptic agents less frequently (1 vs 11%, p < 0.001). The factors reported to influence antidepressant prescription differed in the two groups of physicians. Postuniversity teaching, hospital specialist information and registered indication were considered more important by general practitioners than psychiatrists, who reported to be more influenced by patients' and colleagues' opinions. CONCLUSION: These results demonstrated that the differences in intention in prescribing between psychiatrists and general practitioners can be explained by a different approach to prescription since psychiatrists place more importance on human and clinical factors (patients' and colleagues' opinions) than general practitioners, who referred more to 'official' data (university, hospital and registered indications).

[Prevalence of cancer, health care and daily life assistance in people aged 75 or over living in the Tarn area (France)]. / Prévalence du cancer, recours aux soins et aide dans la vie quotidienne chez les personnes âgées de 75 ans et plus dans le Tarn (France).

The association between cancer and dependence was estimated using a cross-sectional study among persons 75 years of age or-older in Tarn county (area with a cancer registry recognized by the National Committee of Registries). A representative random sample stratified on age, sex, and size of district, was drawn using the electoral registers. Each person randomly selected answered the questions of a surveyor about previous history of cancer, aid in daily life activities and use of health care. Among 5,161, the questionnaire was filled for 3,368 persons (participation: 65.3%). Only 2.3% declared a past history of cancer (cancers diagnosed before 1982 and cancers of the skin excluded). After verification 12.6% of the men and 5.2% of the women in the sample were found in the registry. This result shows a very high tendency for people not to declare their disease. From 75 years of age, 1 man among 8, and 1 woman among 20 suffer or have suffered from a cancer during the last 12 years. Only a weak association between prevalence of cancer and aid in daily life activities could be found, probably explained by the important polymorbidity existing in this age group. The persons who suffered from cancer, are not more often confined in bed or in old people's home. Regarding use of health care, they see a nurse or their general practitioner more frequently, they have been operated or admitted in the hospital more frequently than persons without a past history of cancer. Persons with a past history of ear-nose-throat cancer differ from other cancers by needing more aid to go out of their home, and by taking medical advice more frequently. Except for the ear-nose-throat cases, cancer (aside from the acute stage) does not generate more dependence or hinder the quality of survival, in comparison to those of people of the same age.

[The quality of voter registration lists and participation factors during a community survey of elderly people]. / Qualité des listes électorales et facteurs de participation lors d'une enquête communautaire auprès de personnes âgées.

Electoral registers are often used to randomly select persons for epidemiological surveys. The importance and the different types of inaccurate informations found in these lists were studied during a survey among an elderly population of 5,161 persons aged 75 and over in Tarn area. Information was found to be inaccurate in 13.7% of the cases (people who have died 3%, moved out of the area 10.5%, inaccurate date of birth 0.2%), this increased with age and with size of the parish. The overall participation was 65.3%. The corrected participation (with exclusion of inaccurate information) was 75.7% and was higher in rural parishes and where the help of local organizations of elderlies was available.

D-dimer test and diagnosis of deep vein thrombosis: a comparative study of 7 assays.

The current D-Dimer ELISA methods provide high sensitivity and negative predictive value for the diagnosis of deep vein thrombosis but these methods are not suitable for emergency or for individual determination. We have evaluated the performance of 3 newly available fast D-Dimer assays (Vidas D-Di, BioMérieux; Instant IA D-Di, Stago; Nycocard D-Dimer, Nycomed) in comparison with 3 classic ELISA methods (Stago, Organon, Behring) and a Latex agglutination technique (Stago). One-hundred-and-seventy-one patients suspected of presenting a first episode of deep vein thrombosis were investigated. A deep vein thrombosis was detected in 75 patients (43.8%) by ultrasonic duplex scanning of the lower limbs; in 11 of them the thrombi were distal and very limited in size (< 2 cm). We compared the performance of the tests by calculating their sensitivity, specificity, positive and negative predictive value for different cut-off levels and by calculating the area under ROC curves. The concordance of the different methods was evaluated by calculating the kappa coefficient. The performances of the 3 classic ELISA and of the Vidas D-Di were comparable and kappa coefficients indicated a good concordance between the results provided by these assays. Their sensitivity slightly declined for detection of the very small thrombi. Instant IA D-Di had a non-significantly lower sensitivity and negative predictive value than the 4 previous assays; however its performance was excellent for out-patients. As expected, the Latex assay had too low a sensitivity and negative predictive value to be recommended. In our hands, Nycocard D-Dimer also exhibited low sensitivity and negative predictive value, which were significantly improved when the plasma samples were tested by the manufacturer. Thus significant progress has been made, allowing clinical studies to be planned to compare the safety and cost-effectiveness of D-Dimer strategy to those of the conventional methods for the diagnosis of venous thrombosis.

High level of hepatitis C endemicity in Gabon, equatorial Africa.

To assess the prevalence of hepatitis C virus (HCV) infection, a community-based study was performed in eastern Gabon on 1172 subjects over 5 years of age. The prevalence of antibodies to HCV (anti-HCV) detected using second-generation enzyme-linked immunosorbent assay (ELISA) and confirmed by an immunoblot assay (RIBA 2), was 6.5%. Anti-HCV prevalence increased with age but was related to neither sex nor ethnic group. Among 30 subjects with positive ELISA results, 14 had HCV viraemia as shown by the polymerase chain reaction (11/12 RIBA positive, 2/15 RIBA negative, 1/3 RIBA indeterminate). We conclude that HCV is highly endemic in western equatorial Africa and that a high proportion of the population may be viraemic.