Supplementation with dry Mimosa caesalpiniifolia leaves can reduce the Haemonchus contortus worm burden of goats.

Gastrointestinal nematodes (GINs) cause considerable economic losses in grazing goat herds. At present, GIN control cannot rely on conventional anthelmintic (AH) drugs because parasites have developed resistance against such drugs. Thus, alternative control methods are being sought to reduce the dependence on AH. Many tannin-rich plants exhibit AH activity and may be used as alternatives for GIN control. Mimosa caesalpiniifolia is a tannin-rich shrub consumed by small ruminants in Brazil. This study evaluated the in vivo AH effect of M. caesalpiniifolia leaf powder supplementation on GIN egg fecal excretion and worm burden in goats. Plant leaves were harvested, dried and ground to obtain a powder. Twenty-four castrated male goats, aged six to eight months, with a mean body weight of 15.0 ±â€¯2.5 kg were used in the experiment. Animals were infected orally with 16,000 larvae comprising 50% Haemonchus spp., 41% Trichostrongylus spp. and 9% Oesophagostomum spp. Once the infection was patent, the goats were distributed into four groups of six animals. The control group received concentrate without condensed tannins (CTs) and did not receive any drench against GINs. The monepantel group received concentrate without CTs and were drenched once with monepantel. The other two groups received the M. caesalpiniifolia leaf powder in two periods of seven consecutive days (days 1-7 and 14-21), with one of the groups also receiving 10 g of polyethyleneglycol (PEG)/day. The animals were weighed weekly, and individual fecal eggs counts (FECs) were performed daily. After 28 days, the animals were humanly slaughtered, and the worm burden was estimated. Although live weight gain and FECs did not differ among the groups (P > 0.05), post-mortem worm counts showed a reduction in Haemonchus contortus adult worm burden (57.7%) in goats of the CT group compared to control goats (P < 0.05). The addition of PEG did not diminish AH activity in the CT + PEG group (66.9% reduction compared to the control). No AH effect against other GIN species was found. The result for the addition of PEG suggested that the observed AH activity was associated with plant secondary compounds, as opposed to CTs. As expected, no AH effect against Oesophagostomum columbianum was found for the monepantel group showed. Thus, feeding dry leaves of M. caesalpiniifolia represent a promising alternative for the control of GIN infections in goats.

Cavernous sinus syndrome as the first manifestation of metastatic breast disease.

BACKGROUND: The cavernous sinus is a venous plexus crossed by vital neurovascular structures. Metastases to the region are uncommon and often associated with a headache, facial pain, or progressive neurological deficit in III, IV, and VI cranial nerves. The treatment options are surgery, including endoscopic approach, radiotherapy, radiosurgery, and chemotherapy. CASE DESCRIPTION: We report the case of a 26-year-old female with cavernous sinus syndrome due to breast cancer metastasis, who was subjected to chemotherapy with complete neurological recovery. A literature review was performed using the databases Bireme, Pubmed, Cochrane, Lilacs and Medline with the keywords: cavernous sinus/metastasis/surgery/radiosurgery for multiple management options review. CONCLUSION: Cavernous sinus metastases are rare, and the cavernous sinus syndrome is rarely the first sign of cancer, especially in young patients. Because the syndrome has multiple causes, the history of rapid progression and atypical image findings can arise suggesting metastatic diseases. As in our case, the image was suggestive of meningioma, however, the clinical presentation and further investigations led us to suspect as a metastatic disease. The therapeutic decision considers clinical and functional status, the extent of primary and metastatic disease, radiological study, tumor histopathology, and biological behavior. Often associated with significant symptoms and disseminated systemic disease, nowadays radiosurgery is the first and less invasive strategy, offering low risk of new deficits, clinical improvement, and good local control. The prognosis depends on early treatment and disease staging because mortality is associated with progression of cancer.

Síndrome do túnel do carpo: estudo retrospectivo de 106 casos e complicaçöes / Carpal tunnel syndrome: retrospective study of 106 cases and complications

Fazemos breve revisäo das bases anatômicas e fisiopatológicas da síndrome do túnel do carpo, seu tratamento cirúrgico e suas complicaçöes. Relatamos os casos de duas pacientes que desenvolveram alteraçöes simpáticas como edema da mäo e problemas vasculares (fenômeno de Raynaud) para as quais ensaiamos uma explicaçäo, por nós denominada "denervaçäo, coincidindo com a retirada da imobilizaçäo do punho no 22§ dia pós-operatório

Meningiomas císticos / Cystic meningiomas

A ocorrência de meningiomas císticos é incomum. As imagens destas lesöes obtidas pela tomografia computadorizada de crânio (TC) podem lembrar lesäo cística de origem glial ou metastática, sendo necessário realizarmos, além da TC, angiografia cerebral e ressonância magnética do crânio para firmarmos diagnóstico correto pré-operatório. O diagnóstico incorreto de glioma pode resultar em tratamento paliativo, ao invés da remoçäo radical desta neoplasia potencialmente curável. Três casos säo relatados, ilustrando o problema

Diabetes insipidus traumático: relato de caso / Traumatic diabetes insipidus: a case report

Trata-se do relato do caso de paciente do sexo feminino, com 39 anos, politraumatizada, que desenvolveu quadro de diabetes insipidus. A paciente faleceu onze dias após sua internaçäo, período em que foram realizadas tomografia computadorizada e ressonância magnética, evidenciando lesöes hipotalâmicas características. Estes fatos nos estimularam revisar a literatura e chamar a atençäo para prevençäo de síndromes endócrinas que podem acometer secundária e tardiamente pacientes vítimas de traumatismo crânio-encefálico e que, se diagnosticadas e tratadas de maneira precoce, podem ter sua morbidade diminuída

Ar em hematomas extradurais: relato de dois casos / Air in extradural hematomas: report of 2 cases

Os autores relatam dois casos de presença de ar livre em hematoma extradural agudo. Trata-se de achado radiológico näo incomúm, mas que tem sido relatado infrequentemente na literatura