ABSTRACT
OBJECTIVE: ⢠To review the evidence in support of the effectiveness of phosphodiesterase 5 inhibitors in lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). METHODS: ⢠Relevant studies were identified by performing a literature search using MEDLINE® and The Cochrane Library®. The criteria used during the search included randomized, placebo-controlled trials of treatment for LUTS secondary to BPH using the International Prostate Symptom Score as an outcome measure. RESULTS: ⢠Four trials that included a total of 1928 patients met the inclusion criteria. All four studies showed a statistically significant difference in the International Prostate Symptom Score, quality of life and erectile function in favour of phosphodiesterase 5 inhibitors. ⢠No study showed a statistically significant improvement of the maximum urinary flow. ⢠Meta-analysis of the results was not possible because of heterogeneity across the studies. CONCLUSIONS: ⢠Phosphodiesterase 5 inhibitors used in the clinical setting can significantly improve LUTS secondary to BPH, erectile function and quality of life. Maximum urinary flow improvement is not statistically significant. ⢠Future research should focus on pathophysiological principles and cost analysis.
Subject(s)
Phosphodiesterase 5 Inhibitors/therapeutic use , Prostatic Hyperplasia/drug therapy , Prostatism/drug therapy , Aged , Humans , Male , Middle Aged , Prostatic Hyperplasia/complications , Prostatism/etiology , Randomized Controlled Trials as Topic , Treatment OutcomeABSTRACT
A urolitíase durante o período gestacional é uma patologia que pode determinar riscos à saúde materna e fetal. Diagnóstico e a terapêutica desta patologia envolvem várias especialidades médicas e deve ser do conhecimento do médico plantonista de emergência, do ginecologista, obstetra, infectologista, radiologista e do urologista. Apresentamos neste artigo uma revisao atualizada sobre a litíase urinária na gestaçäo
