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1.
Acta fisiátrica ; 30(4): 218-224, dez. 2023.
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1531092

ABSTRACT

Objetivo: Comparar as respostas neuromusculares e bioquímicas do dano e fadiga muscular do quadríceps femoral entre indivíduos com doença pulmonar obstrutiva crônica (DPOC) e saudáveis. Métodos: Estudo observacional, transversal e comparativo. A amostra foi composta por 18 indivíduos alocados em dois grupos distintos: Grupo DPOC (GD) e grupo saudáveis (GS), os quais foram avaliados por meio da espirometria, do desempenho neuromuscular do quadríceps, dos marcadores bioquímicos do dano e fadiga muscular, da fatigabilidade e da dor muscular. Resultados: Observou-se diferença estatisticamente significante na potência média entre o GD e GS (99,9 ± 21,0 vs 145,1 ± 51,5, respectivamente; p= 0,02) e uma tendência das médias de pico de torque (85,7 ± 24,4 vs 104,4 ± 31,0; p= 0,45) e trabalho total (1.305,5 ± 329,9 vs 1.671,5 ± 444,5; p= 0,06) serem menores no GD que no GS, respectivamente. A concentração da LDH imediatamente após o teste isocinético foi significantemente maior no GD que no GS (402,3 ± 33,6 vs 289,4 ± 33,6, respectivamente; p= 0,03). Conclusões: O presente estudo mostrou que pacientes com DPOC tem redução da capacidade de gerar força em um determinado período de tempo quando comparado a indivíduos saudáveis. A dosagem plasmática dos marcadores bioquímicos não permitiu confirmar que os pacientes com DPOC tem maior nível de dano muscular quando realizam exercício que os controles saudáveis.


Objective: To compare neuromuscular and biochemical responses of femoral quadriceps muscle damage and fatigue between chronic obstructive pulmonary disease (COPD) and healthy subjects. Methods: Observational, transversal and comparative study. The sample consisted of 18 subjects assigned to two distinct groups: COPD group (CG) and healthy group (HG), who were assessed by spirometry, quadriceps neuromuscular performance, biochemical markers of muscle damage and fatigue, fatigability and muscle pain. Results: Statistically significant difference was observed in mean power between CG and HG (99.9 ± 21.0 vs. 145.1 ± 51.5, respectively; p= 0.02) and a tendency of mean peak torque (85.7 ± 24.4 vs 104.4 ± 31.0, p= 0.45) and total work (1,305.5 ± 329.9 vs 1.671.5 ± 444.5; p= 0.06) were smaller in the CG than HG, respectively. The LDH concentration immediately after the isokinetic test was significantly higher in the CG than HG (402.3 ± 33.6 vs 289.4 ± 33.6, respectively; p= 0.03). Conclusions: The present study showed that patients with COPD have a reduced ability to generate force over a given period of time when compared to healthy subjects. The plasma levels of biochemical markers did not confirm that patients with COPD have a higher level of muscle damage when exercising than healthy controls.

2.
Rev. bras. cineantropom. desempenho hum ; 20(2): 125-133, Mar.-Apr. 2018. tab
Article in English | LILACS | ID: biblio-958352

ABSTRACT

Abstract COPD is a pulmonary pathology associated with numerous systemic manifestations, among them musculoskeletal dysfunction. The aim of the study was to evaluate and compare respiratory and peripheral muscle strength in patients with COPD and healthy individuals. This is a cross-sectional, analytical and observational study, in which 18 individuals were evaluated, nine of them with COPD and nine healthy. Femoral quadriceps neuromuscular performance (assessed by means of isokinetic dynamometry), handgrip strength (manual dynamometer) and maximum respiratory pressure (manovacuometry) were evaluated. Data were expressed by mean and standard deviation, analyzed in the SPSS 20.0 statistical package. Significance level of 5% and confidence interval of 95% for all measures were considered. Individuals with COPD had lower quadriceps femoral neuromuscular performance and lower respiratory pressures than healthy subjects; however, there was a statistically significant difference only for muscle power and MIP (p <0.05). Handgrip strength was higher in individuals with COPD (p <0.05). individuals with COPD have neuromuscular changes in peripheral and respiratory muscles that may possibly cause reduced functional performance.


Resumo A DPOC é uma patologia pulmonar, mas que está associada à inúmeras manifestações sistêmicas, dentre elas a disfunção músculoesquelética. Objetivou-se avaliar e comparar a força muscular respiratória e periférica em pacientes com DPOC e indivíduos saudáveis. Trata-se de um estudo transversal, analítico e observacional, no qual foram avaliados 18 indivíduos, sendo nove com DPOC e nove saudáveis. Foram avaliados quanto ao desempenho neuromuscular do quadríceps femoral (avaliado por meio da dinamometria isocinética), força de preensão manual (dinamômetro manual) e pressões respiratórias máximas (manovacuometria). Os dados foram expressos por meio de média e desvio padrão, analisados no pacote estatístico SPSS 20.0. Foi considerado um nível de significância de 5% e intervalo de confiança de 95% para todas as medidas. Os indivíduos com DPOC apresentam desempenho neuromuscular de quadríceps femoral e pressões respiratórias máximas inferiores aos sujeitos saudáveis, no entanto houve diferença estatisticamente significante apenas para potência muscular e PImáx (p<0,05). Já a força de preensão manual foi maior em indivíduos com DPOC (p<0,05). Os sujeitos com DPOC possuem alterações neuromusculares em músculos periféricos e respiratórios que possivelmente podem causar redução do desempenho funcional.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Pulmonary Disease, Chronic Obstructive , Muscle Strength/physiology , Respiratory Muscles/physiopathology
3.
J Bras Pneumol ; 36(4): 447-52, 2010.
Article in English, Portuguese | MEDLINE | ID: mdl-20835591

ABSTRACT

OBJECTIVE: To determine whether the Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE) index correlates with health-related quality of life in patients with COPD. METHODS: We evaluated 42 patients with COPD, quantifying the following: lung function parameters; anthropometric variables; exercise capacity, with the six-minute walk test; dyspnea, with the modified Medical Research Council (MRC) scale; the BODE index; and quality of life, with the modified Saint George's Respiratory Questionnaire (mSGRQ). Patients were divided into two groups by disease severity: FEV1 >or= 50% and FEV1 < 50%. RESULTS: The mean BODE index was 2.58 ± 1.17 and 4.15 ± 1.81, respectively, for the FEV1 >or= 50% and FEV1 < 50% groups. There was a significant difference between the groups in terms of FEV1 and the FEV1/FVC ratio. There were moderate to significant correlations between the BODE index scores and all of the mSGRQ domains in the group of patients with FEV1 <50%. CONCLUSIONS: The BODE index score correlated with the scores of all of the mSGRQ domains in COPD patients with FEV1 < 50%. Therefore, COPD patients with FEV1 < 50% die sooner and have a poorer quality of life.


Subject(s)
Body Mass Index , Dyspnea/physiopathology , Exercise Tolerance/physiology , Pulmonary Disease, Chronic Obstructive/physiopathology , Quality of Life , Female , Forced Expiratory Volume/physiology , Humans , Male , Middle Aged , Reference Values
4.
J. bras. pneumol ; 36(4): 447-452, jul.-ago. 2010. ilus, tab
Article in Portuguese | LILACS | ID: lil-557135

ABSTRACT

OBJETIVO: Determinar se há uma correlação entre o índice Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE; IMC, obstrução das vias aéreas, dispneia e capacidade de exercício) e a qualidade de vida relacionada à saúde em pacientes com DPOC. MÉTODOS: Foram avaliados 42 pacientes com DPOC quanto a parâmetros de função pulmonar; variáveis antropométricas; capacidade de exercício através da distância máxima percorrida no teste de caminhada de seis minutos; dispneia através da escala modificada Medical Research Council (MRC); índice BODE; e a qualidade de vida através do questionário do Saint George's Respiratory Questionnaire modificado (SGRQm). Os pacientes foram alocados em dois grupos de acordo com a estratificação de gravidade da doença: VEF1 > 50 por cento e VEF1 < 50 por cento. RESULTADOS: Os valores médios do índice BODE para os grupos VEF1 > 50 por cento e VEF1 < 50 por cento foram, respectivamente, 2,58 ± 1,17 e 4,15 ± 1,81. Houve diferença significativa na comparação das variáveis VEF1 e VEF1/CVF entre os grupos. Houve correlações moderadas e significativas entre os escores do índice BODE e todos os domínios do SGRQm no grupo de pacientes com VEF1 < 50 por cento. CONCLUSÕES: Houve correlação entre o escore do índice BODE e os escores de todos os domínios do SGRQm nos pacientes com DPOC com VEF1 < 50 por cento. Portanto, os pacientes DPOC com VEF1 < 50 por cento morrem mais rápido e têm pior qualidade de vida.


OBJECTIVE: To determine whether the Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE) index correlates with health-related quality of life in patients with COPD. METHODS: We evaluated 42 patients with COPD, quantifying the following: lung function parameters; anthropometric variables; exercise capacity, with the six-minute walk test; dyspnea, with the modified Medical Research Council (MRC) scale; the BODE index; and quality of life, with the modified Saint George's Respiratory Questionnaire (mSGRQ). Patients were divided into two groups by disease severity: FEV1 > 50 percent and FEV1 < 50 percent. RESULTS: The mean BODE index was 2.58 ± 1.17 and 4.15 ± 1.81, respectively, for the FEV1 > 50 percent and FEV1 < 50 percent groups. There was a significant difference between the groups in terms of FEV1 and the FEV1/FVC ratio. There were moderate to significant correlations between the BODE index scores and all of the mSGRQ domains in the group of patients with FEV1 <50 percent. CONCLUSIONS: The BODE index score correlated with the scores of all of the mSGRQ domains in COPD patients with FEV1 < 50 percent. Therefore, COPD patients with FEV1 < 50 percent die sooner and have a poorer quality of life.


Subject(s)
Female , Humans , Male , Middle Aged , Body Mass Index , Dyspnea/physiopathology , Exercise Tolerance/physiology , Pulmonary Disease, Chronic Obstructive/physiopathology , Quality of Life , Forced Expiratory Volume/physiology , Reference Values
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