[Peculiarities of bone metabolism in healthy men of Georgian nationality].

The purpose of the present research was studying parameters of the bone metabolism and bone mineral density in the context of the risk - factor of osteoporosis among young healthy men. 56 practically healthy men in the age of 22-37 years were investigated. With the help of ultrasonic densitometry cases of osteopenia and osteoporosis were revealed. The received data confirm opinion about non-uniform bone mineral density among men of young age. This indicate to the importance of early detection of cases of osteoporosis among the healthy population with the purpose of conducting timely preventive measures.

[Osteoporosis during rheumatoid arthritis and the peculiarities of its treatment].

The goal of the work was to study the markers of bone metabolism and the indicators of mineral density of bone tissue (MDBT) in the patients with rheumatoid arthritis (RA). 40 patients with rheumatoid arthritis have been investigated who had not received the glucocorticosteroids. For investigation a complex of biochemical markers of bone metabolism have been applied. The obtained results have revealed the increase of excretion of calcium with urine which testifies the increased resorbtion of bone tissue in comparison to norm. The results of dual energy X-ray absorbtiometry (DEXA) have proved the frequency of osteopenia and osteoporosis during the RA; At the same time the inhomogenity of these indices in various fragments of the skeleton was shown. It has been established that lower indices of MDBT were revealed in patients with RA in proximal parts of hip bone and in distal part of forearm. Degree of osteopenia and osteoporosis in these fragments are in correlation with the indices of activity of inflammatory process which gives a possibility to recommend them as the indicators of generalization of osteoporosis. Revealing of osteopenia and osteoporosis in a distal part of the forearm at the earlier stages of the disease does not exclude a possibility of applying the indicators of MDBT as the early diagnostic markers.