Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Psoriasis/drug therapy , Thalidomide/analogs & derivatives , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology , Male , Middle Aged , Psoriasis/complications , Psoriasis/diagnosis , Psoriasis/immunology , Severity of Illness Index , Thalidomide/therapeutic use , Treatment OutcomeSubject(s)
Cyclosporine/therapeutic use , Immunosuppressive Agents/therapeutic use , Lymphohistiocytosis, Hemophagocytic/drug therapy , Lymphoma, T-Cell/drug therapy , Panniculitis/drug therapy , Skin Neoplasms/drug therapy , Adult , Female , Humans , Lymphohistiocytosis, Hemophagocytic/complications , Lymphohistiocytosis, Hemophagocytic/pathology , Lymphoma, T-Cell/complications , Lymphoma, T-Cell/pathology , Panniculitis/complications , Panniculitis/pathology , Skin Neoplasms/complicationsSubject(s)
Alopecia/chemically induced , Biological Products/adverse effects , Certolizumab Pegol/adverse effects , Psoriasis/chemically induced , Sacroiliitis/drug therapy , Alopecia/diagnosis , Alopecia/pathology , Biological Products/administration & dosage , Biopsy , Certolizumab Pegol/administration & dosage , Drug Substitution , Female , Humans , Middle Aged , Psoriasis/diagnosis , Psoriasis/pathology , Skin/drug effects , Skin/pathology , Ustekinumab/administration & dosageABSTRACT
Bullous pemphigoid (BP) is an acquired autoimmune bullous disease characterized by autoantibodies against the hemidesmosomal proteins found in the basal keratinocytes of the basement membrane zone (BMZ): a 180 kDa protein (type XVII collagen) mainly and the 230 kDa antigen. There is such evidence that the antibodies against the BMZ components are not only of IgG type, but also this bullous disease may have IgE antibodies directed to the BMZ that contribute to the pathogenesis of the disorder. IgE is not only thought to contribute to the pathogenesis of BP, it has also been suggested that eosinophils play a role in the development of the first signs associated with BP. A humanized monoclonal antibody directed to IgE, omalizumab, is approved for the treatment of severe asthma and chronic spontaneous urticaria, and it may be useful in the treatment of BP in the first stages of the disease.