ABSTRACT
Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation and the skin is the most commonly involved organ. The clinical presentation is varied and may resemble autoimmune diseases, such as scleroderma, lichen planus or lichen sclerosus. Chronic GVHD presenting with a butterfly malar rash mimicking lupus erythematosus is uncommon. We report a series of five patients with cutaneous lichenoid GVHD that presented with a butterfly malar rash. Two of our patients had positive antinuclear antibody titres. The evolution was poor with development of sclerodermatous GVHD lesions in three patients and relapse of their haematological disease in two.
Subject(s)
Graft vs Host Disease/pathology , Lichen Sclerosus et Atrophicus/pathology , Lupus Erythematosus, Cutaneous/pathology , Skin/pathology , Adolescent , Adult , Bone Marrow Transplantation/adverse effects , Fatal Outcome , Female , Graft vs Host Disease/diagnosis , Graft vs Host Disease/etiology , Humans , Lichen Sclerosus et Atrophicus/diagnosis , Lichen Sclerosus et Atrophicus/etiology , Male , Middle Aged , Transplantation, Homologous/adverse effectsSubject(s)
AIDS-Related Opportunistic Infections , Leishmaniasis, Cutaneous/etiology , Leishmaniasis, Visceral/complications , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/parasitology , Adult , Child , Humans , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/pathology , Leishmaniasis, Visceral/diagnosis , Leishmaniasis, Visceral/parasitologyABSTRACT
A case of halo eczema in melanocytic nevi is reported. Immunohistochemical techniques using monoclonal antibodies distinguished this condition from halo nevus. The lack of the expression of interleukin 2 receptor by T lymphocytes in the infiltrate suggest that the process is probably different from that of the allergic contact dermatitis.
