Personalized Nutritional Therapy Based on Blood Data Analysis for Malaise Patients.

As medical doctors, we routinely check patient blood chemistry and CBC data to diagnose disease. However, these data and methods of analysis are very rarely used to find pre-disease conditions or treat undiagnosed malaise. Masatoshi Kaneko Ph.D. found that many pre-disease conditions and types of malaise could be detected using his unique method of blood data analysis, and could also be treated using personalized nutritional therapy as an alternative to using drugs. The authors of this article introduce personalized nutritional therapy based on blood data analysis (Kaneko's method), and present and discuss some clinical cases. In total, 253 pre-disease or undiagnosed patients were treated using this nutritional therapy approach, and most of them recovered from their chronic symptoms and pre-disease conditions. This novel nutritional therapy has the potential to help many presymptomatic and undiagnosed patients suffering from malaise.

Lower face-lift with expanded polytetrafluoroethylene superficial musculoaponeurotic system extension graft (bandlift implant).

We introduce the expanded polytetrafluoroethylene (ePTFE) superficial musculoaponeurotic system extension graft (SEG) as an effective method of lower face-lift and an alternative to the minimally invasive lower face-lift and thread-lift. During a 4.5-year period, 450 lower face-lifts with ePTFE SEG were performed. The procedure consisted of a primary ePTFE grafting operation followed by a secondary ePTFE SEG traction operation 3 to 4 weeks later; the skin flap was then excised and redraped to adjust the postauricular sulcus. No major complications resulted from surgery, but minor complications included wound infection (2.7%), insufficient traction (1.8%), slipped ePTFE graft (1.3%), temporary earlobe numbness (1.1%), asymmetric traction (0.9%), occipital pain (0.7%), and hematoma below the earlobe (0.2%). Lower face-lift with ePTFE SEG produces satisfactory results for both patients and surgeons in view of the short recovery time, less minimal invasion, simple techniques, and long-lasting outcome when compared with other minimally invasive methods of lower face-lift.

Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects.

This paper describes the process of encapsulating hair growing ingredients in the PLGA nanospheres by emulsion solvent diffusion method and investigates the feasibility of using the PLGA nanospheres as the DDS (Drug delivery System) carriers for delivering various hair growing ingredients to hair follicles. In-vitro and in-vivo tests were conducted to verify the performances of encapsulated PLGA nanospheres with three different hair growing ingredients. In the in-vitro tests, the scalp-pore permeability of hair growing ingredient encapsulated PLGA nanospheres (dispersed in the PBS solution) was examined using human scalp biopsies in a modified Bronaugh diffusion chamber in comparison to that of the control samples containing the hair growing ingredient in the PBS solution. Furthermore, the hair growing effect of the encapsulated PLGA nanospheres was evaluated with the C3H mice in the in-vivo tests. By observing the fluorescence intensity of the ingredients, as shown in the cross-section photographs of the human scalp biopsies, it was found that the dispersion liquids containing hair growing ingredient encapsulated PLGA nanospheres exerted a scalp-pore permeability 2.0- to 2.5-fold more marked than that of the control samples. Also, the hair growing activities were enhanced by using the encapsulated PLGA nanospheres, which transformed the hair growth cycle from the resting phase to the growing phase. As a result, the degree of hair growth was improved significantly. These results suggested that the PLGA nanosphere can be a new DDS carrier for delivering hair growing ingredients and drugs to the hair follicles.