ABSTRACT
The survey was conducted on patients with type 2 diabetes mellitus and on patients with ischemic stroke aggravated and not aggravated by type 2 diabetes mellitus. A comparative study of the function of antioxidant system and the intensity of oxidative stress induced by lipid peroxidation (LPO) in the blood was carried out. Stroke aggravated by diabetes was characterized by higher intensity of LPO than stroke not aggravated by diabetes, which, apparently, determines the more severe course of stroke in patients with diabetes. The mechanisms of compensatory response to oxidative stress at the level of antioxidants in stroke aggravated by diabetes also differed from those in stroke not aggravated by diabetes. These data indicate the need of using water-soluble low-molecular-weight antioxidants in the treatment of stroke aggravated by diabetes.
Subject(s)
Antioxidants/metabolism , Brain Ischemia/blood , Diabetes Mellitus, Type 2/blood , Lipid Peroxidation , Oxidative Stress , Aged , Brain Ischemia/complications , Brain Ischemia/enzymology , Case-Control Studies , Ceruloplasmin/metabolism , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/enzymology , Female , Humans , Lipid Peroxides/blood , Male , Middle Aged , Statistics, NonparametricABSTRACT
Activities of the complement classical, alternative and lectin pathways were determined under conditions of X-radiation in the blood of rats treated and none-treated with synthetic Schiffbase aromatic amino acid derivatives, nicotinyl-L-tyrosinate or nicotinyl-L-tryptophanate, before irradiation. In case of activities of the alternative and lectin pathways no significant changes between irradiated animals and none-irradiated control animals were detected. However, the data obtained demonstrate significantly elevated activity of the classical complement cascade in the blood of irradiated animals (1 day after irradiation), as compared to those none-irradiated. This effect was less pronounced in rats treated with nicotinyl-L-tyrosinate or nicotinyl-L-tryptophanate 1 hour before irradiation. Based on the results obtained the ability of nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate to act as cyto-protectors is concluded.
Subject(s)
Complement Pathway, Alternative/radiation effects , Complement Pathway, Classical/radiation effects , Complement Pathway, Mannose-Binding Lectin/radiation effects , Nicotinic Acids/therapeutic use , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Schiff Bases/therapeutic use , Tryptophan/analogs & derivatives , Tryptophan/therapeutic use , Tyrosine/analogs & derivatives , Tyrosine/therapeutic use , Animals , Male , Nicotinic Acids/administration & dosage , Radiation Injuries, Experimental/blood , Radiation-Protective Agents/administration & dosage , Rats , Rats, Inbred Strains , Schiff Bases/administration & dosage , Treatment Outcome , Tryptophan/administration & dosage , Tyrosine/administration & dosage , X-Rays/adverse effectsABSTRACT
The concentrations and protein composition of immune complexes circulating in the blood of patients with residuals of ischemic stroke and their healthy relatives from families with positive history of stroke have been determined. The data obtained have been compared with the results of our previous study on determination of concentration and protein composition of immune complexes circulating in the blood of patients with acute ischemic stroke and healthy subjects. Basing on the results obtained we conclude that the elevated level of immune complexes in the blood of patients with residuals of stroke is not genetically determined but rather reflects alterations developing as the result of previous stroke. However, the protein composition of the immune complexes, particularly the presence of C-reactive protein, may, to a certain degree, reflect genetic predisposition to stroke.
