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Anim Sci J ; 85(12): 976-80, 2014 Dec.
Article in English | MEDLINE | ID: mdl-24961772

ABSTRACT

In the mouse, L-amino acid oxidase (LAO) produces hydrogen peroxide by utilizing free amino acids and is a proven antibacterial factor in mammary glands. Mastitis, a bacterial infection of the mammary gland, is the most frequent disease in dairy cattle. Here, we investigate whether LAO is expressed in the mammary gland of dairy cattle and is antibacterial. In dairy cattle, the expression level of LAO mRNA in the mammary gland was considerably lower than that in mice, and LAO activity was not observed in cattle milk that produced hydrogen peroxide. The expression of LAO mRNA was also low in Japanese Black cattle, the same as in Holstein cattle. A higher LAO mRNA expression was observed in the mastitis glands than in the lactating glands. Furthermore, spleen and lymph nodes expressed high levels of LAO mRNA in dairy cattle. We conclude that mammary glands in dairy cattle have lower ability to express the LAO gene compared to that in mice, which may result in a high incidence of mastitis.


Subject(s)
Gene Expression , L-Amino Acid Oxidase/genetics , Mammary Glands, Animal/enzymology , Mastitis, Bovine/enzymology , Mastitis, Bovine/genetics , Amino Acids/metabolism , Animals , Anti-Bacterial Agents , Cattle , Female , Hydrogen Peroxide/metabolism , L-Amino Acid Oxidase/physiology , Lactation/genetics , Lactation/metabolism , Mice , Mice, Inbred ICR , RNA, Messenger/metabolism
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