ABSTRACT
The causes of development of ischemic heart failure (IHF) are various, its consequence is the non-adequate blood supply to the organs and tissues. A model of the functional respiratory system (FRS) is the most acceptable for the theoretical investigation of the hypoxical states of organism suffering from IHF. For remodeling and determining a degree of damage of coronary vessels, a four-chamber model of the heart was used with coronary vessels leading to each chamber.
Subject(s)
Hypoxia/etiology , Models, Cardiovascular , Myocardial Ischemia/complications , Algorithms , HumansABSTRACT
The health of a person and his capacity for work under conditions of high mountains in many respects is determined by the reliability of the function of physiological systems. Mathematical methods of both the reliability theory and mathematical simulation of basic functional systems are proposed to be used for investigating the reliability. It is shown that the most suitable reliability model for living systems is a chain model-a successive connection of links representing separate functional systems of organism. Besides, the weakest links determining the reliability of functioning of the whole organism under the extreme conditions of high mountains even for a healthy person are-respiration, blood circulation, thermoregulation and psychophysiological systems. Quantitative characteristics of the reliability of these systems are determined through the main indicators. The influence of non-sufficient contents of oxygen in respiration mixture, low atmospheric pressure, low temperatures of the environment are simulated by computer models of organism. An analyses of modeling data shows that moderate physical loading improves indicators of organisms adaptively to external conditions of high mountains and promotes the increasing of persons capacity for work and the reliability of his functioning.
