Automatic detection of facial expressions during the Cyberball paradigm in Borderline Personality Disorder: a pilot study.

Borderline Personality Disorder (BPD) symptoms include inappropriate control of anger and severe emotional dysregulation after rejection in daily life. Nevertheless, when using the Cyberball paradigm, a tossing game to simulate social exclusion, the seven basic emotions (happiness, sadness, anger, surprise, fear, disgust, and contempt) have not been exhaustively tracked out. It was hypothesized that these patients would show anger, contempt, and disgust during the condition of exclusion versus the condition of inclusion. When facial emotions are automatically detected by Artificial Intelligence, "blending", -or a mixture of at least two emotions- and "masking", -or showing happiness while expressing negative emotions- may be most easily traced expecting higher percentages during exclusion rather than inclusion. Therefore, face videos of fourteen patients diagnosed with BPD (26 ± 6 years old), recorded while playing the tossing game, were analyzed by the FaceReader software. The comparison of conditions highlighted an interaction for anger: it increased during inclusion and decreased during exclusion. During exclusion, the masking of surprise; i.e., displaying happiness while feeling surprised, was significantly more expressed. Furthermore, disgust and contempt were inversely correlated with greater difficulties in emotion regulation and symptomatology, respectively. Therefore, the automatic detection of emotional expressions during both conditions could be useful in rendering diagnostic guidelines in clinical scenarios.

Modeling vulnerability and intervention targets in the Borderline Personality Disorder system: A network analysis of in silico and in vivo interventions.

Modeling psychopathology as a complex dynamic system represents Borderline Personality Disorder (BPD) as a constellation of symptoms (e.g., nodes) that feedback and self-sustain each other shaping a network structure. Through in silico interventions, we simulated the evolution of the BPD system by manipulating: 1) the connectivity strength between nodes (i.e., vulnerability), 2) the external disturbances (i.e., stress) and 3) the predisposition of symptoms to manifest. Similarly, using network analysis we evaluated the effect of an in vivo group psychotherapy to detect the symptoms modified by the intervention. We found that a network with greater connectivity strength between nodes (more vulnerable) showed a higher number of activated symptoms than networks with less strength connectivity. We also found that increases in stress affected more vulnerable networks compared to less vulnerable ones, while decreases in stress revealed a hysteresis effect in the most strongly connected networks. The in silico intervention to symptom alleviation revealed the relevance of nodes related to difficulty in anger regulation, nodes which were also detected as impacted by the in vivo intervention. The complex systems methodology is an alternative to the common cause model with which research has approached the BPD phenomenon.

Machine learning detects predictors of symptom severity and impulsivity after dialectical behavior therapy skills training group in borderline personality disorder.

Only 50% of the patients with Borderline Personality Disorder (BPD) respond to psychotherapies, such as Dialectical Behavioral Therapy (DBT), this might be increased by identifying baseline predictors of clinical change. We use machine learning to detect clinical features that could predict improvement/worsening for severity and impulsivity of BPD after DBT skills training group. To predict illness severity, we analyzed data from 125 patients with BPD divided into 17 DBT psychotherapy groups, and for impulsiveness we analyzed 89 patients distributed into 12 DBT groups. All patients were evaluated at baseline using widely self-report tests; ∼70% of the sample were randomly selected and two machine learning models (lasso and Random forest [Rf]) were trained using 10-fold cross-validation and compared to predict the post-treatment response. Models' generalization was assessed in ∼30% of the remaining sample. Relevant variables for DBT (i.e. the mindfulness ability "non-judging", or "non-planning" impulsiveness) measured at baseline, were robust predictors of clinical change after six months of weekly DBT sessions. Using 10-fold cross-validation, the Rf model had significantly lower prediction error than lasso for the BPD severity variable, Mean Absolute Error (MAE) lasso - Rf = 1.55 (95% CI, 0.63-2.48) as well as for impulsivity, MAE lasso - Rf = 1.97 (95% CI, 0.57-3.35). According to Rf and the permutations method, 34/613 significant predictors for severity and 17/613 for impulsivity were identified. Using machine learning to identify the most important variables before starting DBT could be fundamental for personalized treatment and disease prognosis.

Facial and Vocal Expressions During Clinical Interviews Suggest an Emotional Modulation Paradox in Borderline Personality Disorder: An Explorative Study.

Videotape recordings obtained during an initial and conventional psychiatric interview were used to assess possible emotional differences in facial expressions and acoustic parameters of the voice between Borderline Personality Disorder (BPD) female patients and matched controls. The incidence of seven basic emotion expressions, emotional valence, heart rate, and vocal frequency (f0), and intensity (dB) of the discourse adjectives and interjections were determined through the application of computational software to the visual (FaceReader) and sound (PRAAT) tracks of the videotape recordings. The extensive data obtained were analyzed by three statistical strategies: linear multilevel modeling, correlation matrices, and exploratory network analysis. In comparison with healthy controls, BPD patients express a third less sadness and show a higher number of positive correlations (14 vs. 8) and a cluster of related nodes among the prosodic parameters and the facial expressions of anger, disgust, and contempt. In contrast, control subjects showed negative or null correlations between such facial expressions and prosodic parameters. It seems feasible that BPD patients restrain the facial expression of specific emotions in an attempt to achieve social acceptance. Moreover, the confluence of prosodic and facial expressions of negative emotions reflects a sympathetic activation which is opposed to the social engagement system. Such BPD imbalance reflects an emotional alteration and a dysfunctional behavioral strategy that may constitute a useful biobehavioral indicator of the severity and clinical course of the disorder. This face/voice/heart rate emotional expression assessment (EMEX) may be used in the search for reliable biobehavioral correlates of other psychopathological conditions.

Comorbid personality disorders and their impact on severe dissociative experiences in Mexican patients with borderline personality disorder.

Objective: To identify personality disorders comorbid with borderline personality disorder (BPD) that may confer greater risk for the presence of severe dissociative experiences. Method: Three hundred and one outpatients with a primary diagnosis of BPD were evaluated using the Structured Clinical Interview for DSM-IV Axis II personality disorders, the Borderline Evaluation of Severity Over Time (BEST) and the Dissociative Experiences Scale (DES). Results: The most frequent personality disorders comorbid to BPD were paranoid (83.2%, n = 263) and depressive (81.3%, n = 257). The mean BEST and DES total score were 43.3 (SD = 11.4, range 15-69) and 28.6 (SD = 19.8, range 0-98), respectively. We categorized the sample into patients with and without severe dissociative experiences (41% were positive). A logistic regression model revealed that Schizotypal, Obsessive-compulsive and Antisocial personality disorders conferred greater risk for the presence of severe dissociative experiences. Discussion: Our results suggest that a large proportion of patients with BPD present a high rate of severe dissociative experiences and that some clinical factors such as personality comorbidity confer greater risk for severe dissociation, which is related to greater dysfunction and suffering, as well as a worse progression of the BPD.

Clinical improvement in patients with borderline personality disorder after treatment with repetitive transcranial magnetic stimulation: preliminary results

Objective: Current treatment of borderline personality disorder (BPD) consists of psychotherapy and pharmacological interventions. However, the use of repetitive transcranial magnetic stimulation (rTMS) could be beneficial to improve some BPD symptoms. The objective of this study was to evaluate clinical improvement in patients with BPD after application of rTMS over the right or left dorsolateral prefrontal cortex (DLPFC). Method: Twenty-nine patients with BPD from the National Institute of Psychiatry, Mexico, were randomized in two groups to receive 15 sessions of rTMS applied over the right (1 Hz, n=15) or left (5 Hz, n=14) DLPFC. Improvement was measured by the Clinical Global Impression Scale for BPD (CGI-BPD), Borderline Evaluation of Severity Over Time (BEST), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A), and Barratt Impulsiveness Scale (BIS). Results: Intragroup comparison showed significant (p < 0.05) reductions in every psychopathologic domain of the CGI-BPD and in the total scores of all scales in both groups. Conclusions: Both protocols produced global improvement in severity and symptoms of BPD, particularly in impulsiveness, affective instability, and anger. Further studies are warranted to explore the therapeutic effect of rTMS in BPD. Clinical trial registration: NCT02273674.

Demographic and clinical features related to perceived discrimination in schizophrenia.

Perceived discrimination contributes to the development of internalized stigma among those with schizophrenia. Evidence on demographic and clinical factors related to the perception of discrimination among this population is both contradictory and scarce in low- and middle-income countries. Accordingly, the main purpose of this study is to determine the demographic and clinical factors predicting the perception of discrimination among Mexican patients with schizophrenia. Two hundred and seventeen adults with paranoid schizophrenia completed an interview on their demographic status and clinical characteristics. Symptom severity was assessed using the Positive and Negative Syndrome Scale; and perceived discrimination using 13 items from the King's Internalized Stigma Scale. Bivariate linear associations were determined to identify the variables of interest to be included in a linear regression analysis. Years of education, age of illness onset and length of hospitalization were associated with discrimination. However, only age of illness onset and length of hospitalization emerged as predictors of perceived discrimination in the final regression analysis, with longer length of hospitalization being the independent variable with the greatest contribution. Fortunately, this is a modifiable factor regarding the perception of discrimination and self-stigma. Strategies for achieving this as part of community-based mental health care are also discussed.

Clinical improvement in patients with borderline personality disorder after treatment with repetitive transcranial magnetic stimulation: preliminary results.

OBJECTIVE: Current treatment of borderline personality disorder (BPD) consists of psychotherapy and pharmacological interventions. However, the use of repetitive transcranial magnetic stimulation (rTMS) could be beneficial to improve some BPD symptoms. The objective of this study was to evaluate clinical improvement in patients with BPD after application of rTMS over the right or left dorsolateral prefrontal cortex (DLPFC). METHOD: Twenty-nine patients with BPD from the National Institute of Psychiatry, Mexico, were randomized in two groups to receive 15 sessions of rTMS applied over the right (1 Hz, n=15) or left (5 Hz, n=14) DLPFC. Improvement was measured by the Clinical Global Impression Scale for BPD (CGI-BPD), Borderline Evaluation of Severity Over Time (BEST), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A), and Barratt Impulsiveness Scale (BIS). RESULTS: Intragroup comparison showed significant (p < 0.05) reductions in every psychopathologic domain of the CGI-BPD and in the total scores of all scales in both groups. CONCLUSIONS: Both protocols produced global improvement in severity and symptoms of BPD, particularly in impulsiveness, affective instability, and anger. Further studies are warranted to explore the therapeutic effect of rTMS in BPD. CLINICAL TRIAL REGISTRATION: NCT02273674

Facial Emotion Recognition and Empathy in Employees at a Juvenile Detention Center.

Numerous studies have shown that emotion recognition is impaired in individuals with a history of violent offenses, especially in those diagnosed with psychopathy. However, in criminological contexts, there is insufficient research regarding the role of empathy and facial emotion recognition abilities of personnel employed in correction centers. Accordingly, we sought to explore facial emotion recognition abilities and empathy in administrative officers and security guards at a center for institutionalized juvenile offenders. One hundred twenty-two Mexican subjects, including both men and women, were recruited for the study. Sixty-three subjects were administrative officers, and 59 subjects were security guards at a juvenile detention center. Tasks included "Pictures of Facial Affect" and the "Cambridge Behavior Scale." The results showed that group and gender had an independent effect on emotion recognition abilities, with no significant interaction between the two variables. Specifically, administrative officers showed higher empathy than security guards. Moreover, women in general exhibited more empathy than men. This study provides initial evidence of the need to study emotion recognition and empathy among professionals working in forensic settings or criminological contexts.

Disorders related to sexuality and gender identity in the ICD-11: revising the ICD-10 classification based on current scientific evidence, best clinical practices, and human rights considerations.

In the World Health Organization's forthcoming eleventh revision of the International Classification of Diseases and Related Health Problems (ICD-11), substantial changes have been proposed to the ICD-10 classification of mental and behavioural disorders related to sexuality and gender identity. These concern the following ICD-10 disorder groupings: F52 Sexual dysfunctions, not caused by organic disorder or disease; F64 Gender identity disorders; F65 Disorders of sexual preference; and F66 Psychological and behavioural disorders associated with sexual development and orientation. Changes have been proposed based on advances in research and clinical practice, and major shifts in social attitudes and in relevant policies, laws, and human rights standards. This paper describes the main recommended changes, the rationale and evidence considered, and important differences from the DSM-5. An integrated classification of sexual dysfunctions has been proposed for a new chapter on Conditions Related to Sexual Health, overcoming the mind/body separation that is inherent in ICD-10. Gender identity disorders in ICD-10 have been reconceptualized as Gender incongruence, and also proposed to be moved to the new chapter on sexual health. The proposed classification of Paraphilic disorders distinguishes between conditions that are relevant to public health and clinical psychopathology and those that merely reflect private behaviour. ICD-10 categories related to sexual orientation have been recommended for deletion from the ICD-11.

Estudio de traducción y validez del Sistema de Codificación Etológica para Entrevistas ECSI (Ethological Coding System for Interviews) / Study of the application and validation of the Ethological Coding System for Interviews (ECSI)

Antecedentes El diagnóstico psicoterapéutico se fundamenta en exploraciones verbales y/o pruebas psicológicas. En contraste, a menudo se descuida la relevancia de la comunicación no-verbal. El objetivo del presente artículo es aportar una herramienta para medir y evaluar conductas no-verbales en entrevistas clínicas, basado en el Ethological Coding System for Interviews (ECSI), desarrollado por Troisi (1999), el cual se tradujo y validó en español. Un etograma es un catálogo de conductas o patrones conductuales, operacionalizados y agrupados en categorías, como afiliación, evasión, asertividad, relajación, entre otras. Método Estudio 1. El etograma ECSI fue traducido al español. Tres observadores "ciegos" registraron las frecuencias de los patrones conductuales del paciente. Los registros se realizaron en intervalos de 15 segundos durante los primeros y últimos 10 minutos de la entrevista clínica. Se obtuvo una validez interobservador de r=0.989, p<0.001. Estudio 2. Con base en el primer estudio se consideró pertinente agregar patrones conductuales, así como reacomodar y redefinir las categorías propuestas. Los tres observadores realizaron el mismo procedimiento que en el estudio 1 con una segunda videograbación. Además de las frecuencias de las conductas observadas, se midió la duración de la conducta. Se obtuvo una validez interobservadores de r=0.993, p<0.001. Resultados y discusión Se probó que el ECSI es una herramienta confiable y válida para examinar la conducta no-verbal de pacientes durante entrevistas. Se espera que el ECSI se pueda incluir al proceso diagnóstico durante las sesiones psicoterapéuticas.

Background Psychotherapeutic diagnosis is largely based on verbal explorations and/or psychological tests. In contrast, the relevance of non-verbal communication is often disregarded. Here, we aim to provide a tool to measure and assess non-verbal behavior in clinical interviews, based on the Ethological Coding System for Interviews (ECSI), developed by Troisi (1999), which was translated and validated in Spanish. An ethogram is a catalogue of behaviours or patterns of behaviour, which are operationalized and grouped in categories such as affiliation, flight, assertiveness, relaxation and so forth. Method Study 1. The ECSI was translated into Spanish. Three "blind" observers registered the frequencies of the behavioral patterns of the patient. The recordings were made in 15 seconds intervals during the first and the last 10 minutes of a clinical interview. An inter-observer reliability of r=0.989, p<0.001 was obtained. Study 2. Based on the first study, it was considered pertinent to add behavioral patterns, as well as rearranging and redefining the proposed categories. The three "blind" observers performed the same task as in study 1 with a second video-recording. Aside from the frequency of the observed behaviours, the duration of the behavior was measured. An inter-observer reliability of r=0.993, p<0.001 was obtained. Results and discussion The ECSI has proven a reliable and valid tool for the examination of patients' nonverbal behaviour during interviews. It is hoped that the ECSI can be added to the diagnostic process during psychotherapeutic sessions.

Recognition of facial expression of the emotions and their relation to attachment styles and psychiatric symptoms: Preliminary study on Psychiatric Residents / Reconocimiento de la expresión facial de las emociones y su relación con estilos de apego y síntomas psiquiátricos: Estudio preliminar en Residentes de Psiquiatría

Facial expressions of emotion reveal complex mental states that have physiological correlates and signal internal states such as distress to others and are thus crucial in social interaction. In this preliminary study, we therefore sought to examine the link between current psychiatric symptoms and attachment styles in psychiatry residents and their ability to correctly identify facial expressions of emotions. Specifically, we hypothesized that greater current psychiatric symptoms and insecure attachment would be related to difficulties in deciphering facial expressions of negative emotions. A total of 56 psychiatry residents were included in the study, together with 50 university students pursuing careers unrelated to mental health. In order to evaluate the subjects' psychiatric symptoms, the Checklist (SCL-90) and Attachment Styles Questionnaire (ASQ) were used and in order to examine the ability to recognize facial expressions of emotion, we chose the Pictures of Facial Affect (POFA). All the respondents gave their informed consent in writing. The control group recognized fear significantly less as compared to psychiatry residents. Among psychiatry residents, there was a significantly positive correlation between hostility and fear recognition and anxiety and fear recognition. The same was observed between obsessive-compulsive symptoms and disgust recognition. In the control group, there was a significantly negative correlation between paranoid ideation and phobic anxiety with sadness recognition. In resident psychiatry, happiness recognition was positively related to an attachment-style based on confidence, while sadness recognition and surprise recognition correlated negatively with an attachment style based on considering relationships as being of secondary importance. This is one of the first studies to examine emotion recognition skills in medical professionals, and the association of this ability with psychiatric symptoms and attachment styles. We think it is important to observe longitudinally what the possible relevance of these findings might be for both diagnostic accuracy and therapeutic relationships.

La expresión facial de las emociones revela estados mentales complejos que tienen correlatos fisiológicos y señales de estados internos, como la angustia, y que son esenciales en la interacción social. En el presente estudio preliminar examinamos la asociación entre los síntomas psiquiátricos, los estilos de apego y la habilidad para reconocer correctamente la expresión facial de las emociones básicas, en residentes de psiquiatría de una institución de salud mental de México. La hipótesis es que los síntomas psiquiátricos y el estilo de apego inseguro pueden estar relacionados con una dificultad para descifrar la expresión facial de emociones negativas. Un total de 56 residentes de psiquiatría fueron incluidos en el estudio junto con 50 estudiantes universitarios de la Universidad Nacional Autónoma de México, UNAM, de carreras diferentes a las relacionadas con la salud mental. Se utilizaron los siguientes instrumentos: Los síntomas psiquiátricos se evaluaron con el SCL-90, traducido y validado al español, el Cuestionario de Estilos de Apego (ASQ) traducido y validado al español, y para el reconocimiento de la expresión facial de las emociones se usó el Instrumento de Ekman, denominado Pictures of Facial Affect (POFA). Previamente, todos los participantes dieron su consentimiento informado con la firma de aceptación para participar en el estudio. Los estudiantes del grupo control reconocieron menos el miedo que los residentes de psiquiatría. En los residentes hubo una correlación positiva entre la hostilidad y el reconocimiento del miedo y entre la ansiedad y el reconocimiento del miedo. Lo mismo se observó entre los síntomas obsesivos-compulsivos y el reconocimiento del disgusto. En el grupo control se encontró una correlación negativa entre la ideación paranoide y la ansiedad fóbica con el reconocimiento de la tristeza. En los residentes el reconocimiento de la felicidad se relacionó positivamente con el estilo de apego basado en la confianza, mientras que el reconocimiento del miedo y la sorpresa fueron negativamente relacionados con el estilo de apego basado en considerar las relaciones como secundarias. Este es un primer estudio que examina la habilidad de reconocer las emociones básicas en profesionales de la medicina que están siendo entrenados en la especialidad de psiquiatría, y la relación con síntomas psiquiátricos y estilos de apego. Consideramos importante el estudio de estos factores a lo largo de la formación, por la posible relevancia que estos hallazgos puedan tener para el adecuado diagnóstico y la relación terapéutica.