ABSTRACT
Two cases of adenocarcinoma arising in extraovarian endometriosis 19 and 8 years following abdominal hysterectomy and bilateral salpingo-oophorectomy are described. Both patients presented with hydronephrosis. One had been on chronic estrogen therapy. The literature is reviewed in reference to frequency, tumor type, and sites of occurrence.
Subject(s)
Adenocarcinoma , Endometriosis , Neoplasms, Multiple Primary , Ureteral Neoplasms , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Endometriosis/pathology , Endometriosis/surgery , Female , Humans , Hysterectomy , Middle Aged , Ovariectomy , Ureter/pathology , Ureter/surgery , Ureteral Neoplasms/pathology , Ureteral Neoplasms/surgeryABSTRACT
A neonate with a cerebral gliosarcoma was found to have chromosome abnormalities in tissue culture of the tumor, but normal karyotyping of peripheral blood. Similarities to and differences from chromosome abnormalities found in other human gliomas are noted. Unusual exposure of the child to heptachlor during prenatal development and the neonatal period suggests the need for further studies on the role of toxins in oncogenesis.
Subject(s)
Brain Neoplasms/genetics , Carcinogens/administration & dosage , Chromosome Aberrations , Chromosome Disorders , Glioma/genetics , Heptachlor/administration & dosage , Animals , Brain Neoplasms/chemically induced , Brain Neoplasms/pathology , Chromosome Aberrations/chemically induced , Glioma/chemically induced , Glioma/pathology , Humans , Infant , Male , MilkSubject(s)
Carcinoma, Squamous Cell/therapy , Laryngeal Neoplasms/therapy , Aged , Epiglottis , Humans , MaleABSTRACT
The clinical and radiographic presentations of 3 patients with intraventricular cavernous hemangioma are described. The accumulated total of 19 cases from the literature are compared to determine whether there is a common clinical and radiographic presentation for this benign intraventricular lesion. The differential diagnosis of intraventricular cavernous hemangioma includes intraventricular meningioma, choroid plexus papilloma, arteriovenous malformation, low grade astrocytoma, and ependymoma.
Subject(s)
Cerebral Ventricle Neoplasms/pathology , Hemangioma, Cavernous/pathology , Adult , Cerebral Angiography , Cerebral Ventricle Neoplasms/diagnosis , Cerebral Ventricle Neoplasms/surgery , Female , Hemangioma, Cavernous/diagnosis , Hemangioma, Cavernous/surgery , Humans , Hydrocephalus/complications , Infant , Male , Pneumoencephalography , Tomography, X-Ray ComputedABSTRACT
Analysis of myelin from a leukodystrophic brain was performed (Pelizaeus-Merzbacher disease, classical type). Myelin recovery was 7% of normal, when isolated by ultracentrifugation. Electron microscopy showed a great amount of loose lamellae, with less thick sheaths and periodicity close to normal. This myelin contains fewer lipids than normal, sphingolipids and plasmalogens being reduced. FAtty acids from phospholipids are essentially normal, however enols from plasmalogens are largely reduced. Purified sphingolipids (cerebrosides, sulfatides and sphingomyelin) present a considerable diminution in very long chain fatty acids; the ratio of very long chain fatty acids (over C18) on shorter chains is 1% of the normal value for saturated fatty acids and 2% for the monounsaturated homologues. Protein analysis showed that basic protein and proteolipids were reduced, Wolfgram proteins being relatively increased.
