Association between placenta accreta spectrum and third-trimester serum levels of vascular endothelial growth factor, placental growth factor, and soluble Fms-like tyrosine kinase-1: A meta-analysis.

AIM: Antenatal suspicion of placenta accreta spectrum (PAS) currently relies on ultrasonographic findings, color doppler, and MRI, which have rendered it operator and expertise-dependent. No serum markers for PAS have been integrated into clinical practice yet. The aim of this meta-analysis was to identify potential serum markers for PAS by investigating third-trimester serum levels of vascular endothelial growth factor (VEFG), placental growth factor (PIGF), and soluble Fms-like tyrosine kinase-1 (sFlt-1) among PAS-cases and controls. METHODS: PubMed, Scopus, EBSCO, Web of Science, and CNKI databases were systematically searched for relevant articles. Random-effects model was applied to calculate the overall standardized mean difference (SMD) for each marker. Subgroup analysis and meta-regression were performed to assess for potential covariates. RESULTS: Eight studies involving 366 PAS-cases and 518 controls were included. Third trimester sFlt-1 levels were significantly lower in PAS-cases when compared to controls (SMD = -7.76, 95%CI = -10.42 to -5.10). This was, to a certain extent, consistent among studies though they differed in their extent of significance. Levels of VEGF (SMD = 1.59, 95%CI = -0.07 to 3.25) and PlGF (SMD = -0.49, 95%CI = -1.66 to 0.67) were not significantly different between PAS cases and controls, in which studies demonstrated conflicting results. CONCLUSIONS: Third trimester sFlt-1 levels may be useful to predict PAS. Nonetheless, further studies are recommended to better understand conflicting results before adopting either VEGF or PlGF.

New Pure Organic and Peroxide-Free Redox Initiating Systems for Polymerization in Mild Conditions.

Redox initiating systems (RISs) are highly worthwhile for polymerization in mild conditions (at room temperature-RT) without external thermal or light activation. With high performance redox initiating systems RIS, the free radical polymerization FRP can even be carried out under air and without inhibitors/stabilizers removal from the monomers/resins. However, efficient RISs are still based on peroxides or metal complexes. In this work, a pure organic and peroxide-free RIS is presented based on the interaction of a well-selected triarylamine derivative (T4epa) with iodonium salt used as reducing and oxidizing agents, respectively. The redox polymerization (Redox FRP) was followed through pyrometry and thermal imaging experiments. Remarkably, a full control of the work time as well as a high reactivity is observed for mild conditions.

High Performance Redox Initiating Systems Based on the Interaction of Silane with Metal Complexes: A Unique Platform for the Preparation of Composites.

Currently, Redox Initiating Systems (RISs) of Free Radical Polymerization (FRP) are mainly based on the interaction of aromatic amines with peroxides (e.g., dibenzoyl peroxide (BPO)) that can be both toxic and unstable. In the present work, we aim to replace these hazardous substances in new RIS that can be peroxide-free and amine-free. Our redox two components (2K) initiating system is based on diphenylsilane (DPS) as reducing agent combined with different metal complexes (Mn(acac)2, Cu(AAEMA)2 or Fe(acac)3) as oxidizing agents. For the new proposed RIS, an excellent reactivity is found for the polymerization of benchmark methacrylate monomers under mild conditions (redox polymerization done under air and at room temperature); remarkably, it is also possible to finely control the gel time. Different techniques (optical pyrometry, Real-Time FTIR spectroscopy, Cyclic Voltammetry and Electron Spin Resonance (ESR)) were used to follow the polymerization processes but also to shed some light on the new redox chemical mechanisms.

Carbazole-based compounds as photoinitiators for free radical and cationic polymerization upon near visible light illumination.

Six new carbazole based compounds (Ca1-Ca6) are synthesized and proposed as high performance photoinitiators with iodonium salt (iod) and/or an amine (EDB) for both the free radical polymerization (FRP) of acrylates and the cationic polymerization (CP) of epoxides upon near UV and visible light exposure using light emitting diodes (LEDs) @385 nm and @405 nm. Excellent polymerization initiating abilities are found and high final reactive function conversions are acquired. A full picture of the involved photochemical mechanisms is given.