Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064

The aim of this work was to compare the composition of a complex and soluble culture medium to eight other media described in the literature through the batch cultivation in a conventional bench-scale bioreactor for the production of cephamycin C by a wild strain of Streptomyces clavuligerus. The proposed medium resulted in an antibiotic production 1.5 to 7.5 times higher than the other culture media.

Effect of the carbon sources on the growth kinetics of Cephalosporium acremonium in the Cephalosporin C production process

The growth phase of Cephalosporium acremonium ATCC 48272 was analized in the batch production process of cephalosporin C. Two media were used: one containing glucose and sucrose as main sources of carbon and energy, and the other containing only glucose. The consumption rate of glucose to form biomass was much higher in medium containing only glucose. The behavior in both media could be satisfactorily explained though simulation of a model which included inibition of glucose comsumption by sucrose in the classical Contois kinetics.