ABSTRACT
This review focuses on the interaction between the essential elementvanadium with 1,10-phenanthroline and polypyridyl ligands. It starts with a summary of the prior work on speciation studies for the binary systems vanadium-phenanthroline alongside several hydrolytic studies of the metal ion. It also includes a complete overview on the different X-ray structures known to date with discussions on the potential cytotoxic activity of several vanadium-polypyridyl complexes.
Subject(s)
Antineoplastic Agents/pharmacology , Coordination Complexes/pharmacology , Pyridines/pharmacology , Animals , Antineoplastic Agents/chemistry , Cell Line, Tumor , Coordination Complexes/chemistry , Drug Screening Assays, Antitumor , Humans , Ligands , Molecular Structure , Phenanthrolines/chemistry , Phenanthrolines/pharmacology , Pyridines/chemistry , Vanadium/chemistryABSTRACT
Se presentan los resultados del estudio de los complejos de vanadio(III) con glutatión (GSH, H3L) a 25 °C y en KCl3,0 M mediante medidas de fuerzas electromotrices, emf(H). El análisis de los datos mediante el programa de mínimos cuadrados generalizados LETAGROP indica la formación de cantidades significativas de los complejos VH4l4+, VH3L3+, V(H3L)23+ yv(L)(3L)2+, cuyas constantes de estabilidad fueron determinadas.
The formation of the vanadium(III) complexes with glutathione (GSH, H3L) was studied in 3.0 M KCl at 25 °C by means of electromotive forces measurements, emf (H). The analysis of the potentiometric data by means of the least-squares program LETAGROP indicates the formation of significant quantities of the complexes VH4l4+, VH3L3+, V(H3L)23+ yv(L)(3L)2+, whose stability constants were determined.