Laparoscopic resection of pancreatic masses in 12 dogs.

OBJECTIVE: To describe the surgical management and outcome of dogs undergoing laparoscopic pancreatic mass resection (LPMR). STUDY DESIGN: Retrospective study. ANIMALS: Twelve client-owned dogs. METHODS: Data collected from medical records of dogs that underwent LPMR between 2012 and 2023 included signalment, clinical signs, mass location within pancreas, preoperative diagnostic imaging, laparoscopic approach, number of portals and device type used for LPMR, operating time, complications and clinical outcome. RESULTS: Pancreatic tumors were located in the left lobe (7), in the right lobe (4) and in the body of the pancreas (1). A 3- or 4-port technique was used in nine and three dogs, respectively. LPMR was performed with the Ligasure in nine dogs, a harmonic scalpel in two dogs and an endoscopic stapler in one dog. The procedure was performed successfully, with no conversion to open laparotomy, in all cases with a median operating time of 69 min. Postoperative complications occurred in four dogs, which resolved with medical treatments. All dogs survived the surgical procedure, were discharged from the hospital and alive a minimum of 90 days postoperatively. The final follow-up time ranged between 105 and 245 days (median 147). Histopathological diagnosis included insulinoma (9) and pancreatic carcinoma (3). CONCLUSION: LPMR was performed successfully using a 3- or 4-port technique and was associated with a low complication rate and a good clinical outcome. CLINICAL SIGNIFICANCE: LPMR may be considered as an alternative to open celiotomy in dogs, particularly for small tumors located in the distal aspect of the pancreatic lobes.

Impacto del Entrenamiento Respiratorio de Hiperpnea Isocápnica Voluntaria sobre el Costo Energético asociado a la Respiración inducido por Ejercicio Físico / Impact of Voluntary Isocapnic Hyperpnea training on the cost of breathing

Introducción. Determinar el efecto de ocho semanas de entrenamiento por hiperpnea isocápnica voluntaria (HIV) sobre el costo energético asociado a la respiración (COB) reflejado en los cambios en la oxigenación de los músculos intercostales (∆SmO2-m. intercostales) inducida por ejercicio físico de intensidad incremental. Métodos. Doce participantes físicamente activos fueron entrenados durante ocho semanas de HIV 3 días x semana, 12 minutos, al 60% de ventilación voluntaria máxima (VVM). En la semana previa y posterior al entrenamiento HIV se realizó un test cardiopulmonar (CPET) de intensidad incremental en cicloergómetro, durante esta prueba se registró la ∆SmO2-m. intercostales mediante el dispositivo MOXY®. El efecto de HIV sobre la ∆SmO2-m. intercostales se analizó mediante la prueba two-way mixed ANOVA considerando los factores (fase × tarea). Resultados. ∆SmO2-m.intercostales fue significativamente menor a partir del 30% (­5,0±4,7%; p<0.01) hasta el 100% (­10,6±12,8%; p<0.01) de la tarea luego de ocho semanas de HIV. Además, se reportó un aumento de la presión inspiratoria máxima (PIM)=16,5±11,4 cmH2O (p<0.01); y de la resistencia muscular respiratoria=106,6±149,0 s (p<0.01). El tiempo total de ejercicio aumentó en 106,6±149,0 s (p=0.04), así como la carga total en 10,50± 10,12 vatios (p<0.01). Conclusión. El HIV disminuye el COB inducido por ejercicio incremental asociado a un incremento en la performance física y de los músculos respiratorios. En futuros estudios se sugiere estudiar esta estrategia de entrenamiento analítico de los músculos respiratorios en usuarios con limitación física relacionada al aumento prematuro del COB.

Background. Objetive. To determine the effect of eight weeks of voluntary isocapnic hyperpnea (VIH) training on cost of breathing (COB) as reflected by intercostales muscles deoxygenation (∆SmO2-m. intercostales) induced by incremental-intensity physical exercise. Methods. Twelve physically active participants underwent eight weeks of VIH training, three days a week, for 12 minutes each session, at 60% of maximal voluntary ventilation (MVV). In the week before and after VIH training, a cardiopulmonary test (CPET) of incremental intensity was performed on a cycloergometer. During this test, intercostal ∆SmO2-m.intercostales was recorded using the MOXY® device. The effect of VIH on ∆SmO2-m.intercostales were analyzed using a two-way mixed ANOVA test considering the factors (phase × task). Results. ∆SmO2-m.intercostales significantly decreased from 30% (­5.0±4.7%; p<0.01) to 100% (­10.6±12.8%; p<0.01) of the task after eight weeks of VIH. Additionally, an increase in maximal inspiratory pressure (MIP) of 16.5±11.4 cmH2O (p<0.01) and respiratory muscle endurance of 106.6±149.0 s (p<0.01) was reported. Total exercise time increased by 106.6±149.0 s (p=0.04), as well as total workload by 10.50±10.12 watts (p<0.01). Conclusion. VIH reduces COB induced by incremental exercise and is associated with increased physical and respiratory muscle performance. Future studies should explore this respiratory muscle training strategy for individuals with physical limitations related to a premature increase in COB.

Laparoscopic adrenalectomy for resection of unilateral noninvasive adrenal masses in dogs is associated with excellent outcomes in experienced centers.

OBJECTIVE: To report the short- and long-term outcomes of laparoscopic adrenalectomy (LA) for resection of unilateral adrenal masses and to document risk factors for conversion and peri- and postoperative morbidity. ANIMALS: 255 client-owned dogs. METHODS: Dogs were included if LA was attempted for resection of a unilateral adrenal mass. Medical records were evaluated and relevant data were reported, including complications, conversion, perioperative death, and long-term outcomes. Signalment, clinicopathological data, and surgical experience were factors statistically evaluated for possible associations with capsular penetration during surgery, conversion, surgical time, duration of hospital stay, death prior to discharge, mass recurrence, and survival time. RESULTS: 155 dogs had left-sided tumors, and 100 had right-sided tumors. Conversion to an open approach was performed in 9.4% of cases. Capsular penetration (19.2%) and major hemorrhage (5.4%) were the most prevalent intraoperative complications. Of the dogs operated on, 94.9% were discharged from the hospital. Lesion side, portion of the gland affected, and surgeon experience influenced surgical time. Conversion rate increased with increasing body condition score and lesion size. Risk of death prior to discharge increased with increasing lesion size. Risk of conversion and death prior to discharge were lower when performed by more experienced surgeons. Capsular penetration during LA increased the risk of tumor recurrence. CLINICAL RELEVANCE: LA for resection of unilateral adrenal masses is associated with excellent outcomes in experienced centers. Surgeons with greater experience with LA have lower surgical times, conversion rates, and risk of death prior to discharge.

Participación social en adultos mayores con Enfermedad Pulmonar Obstructiva Crónica: características funcionales y emocionales / Social participation in older adults with Chronic Obstructive Pulmonary Disease: functional and emotional characteristics

Fundamentos: El impacto de la enfermedad pulmonar obstructiva crónica (EPOC) sobre la participación social en actividadesde la comunidad ha sido poco estudiada en adultos mayores. Por esta razón, este estudio analizó los tipos de organizaciones comunitarias donde participan los adultos mayores con EPOC y sus características funcionales y emocionales.Métodos: Fue realizado un estudio transversal con treinta y nueve adultos mayores con EPOC, de la ciudad de Londrina (Brasil),desde el año 2016 hasta 2019. Fue aplicado el cuestionario de participación social para conocer la participación en reuniones oactividades con: 1) organizaciones de adultos mayores; 2) junta de vecinos o partido político; 3) grupos religiosos, de crecimientopersonal o espiritual; 4) actividades familiares o con amigos; y 5) actividades recreativas en la comunidad. Los individuos realizaronel test de marcha de seis minutos (TM6m), Inventario de Depresión de Beck (IDB), evaluación de fuerza de prensión palmar (FPP) y elCOPD Assessment Test (CAT). La comparación entre los adultos mayores que participaron de organizaciones formales e informalesfue realizada utilizando el Test T de Student.Resultados: El 77% de los pacientes con EPOC participaron en grupos religiosos o espirituales y el 74% en actividades con familiares y amigos. Las mujeres participaron más en actividades sociales informales (P=0,002) y formales (P=0,004) que los hombres.Individuos que participaron en actividades sociales son aquellos que tuvieron menor rendimiento en TM6m y mayores puntuacionesen IDB y CAT (P<0,05 para todos).Conclusiones: La participación social de los adultos mayores con EPOC es mayor en grupos religiosos, actividades familiaresy con amigos. Adicionalmente, los adultos mayores que participan en organizaciones comunitarias son aquellos que presentan máslimitaciones funcionales y emocionales...(AU)

Backgroud: The impact of chronic obstructive pulmonary disease (COPD) on social participation in community activities hasbeen scarce studied in older adults. For this reason, this study analyzed the types of community organizations in which older adultswith COPD participate and their functional and emotional characteristics. Methods: A cross-sectional study was conducted with 39 older adults with COPD from the city of Londrina (Brazil), from 2016 to2019. The social participation questionnaire was applied to identify the participation in meetings or activities with: 1) organizations forolder adults; 2) neighbourhood councils or political parties; 3) religious, personal or spiritual growth; 4) family or friends activities; 5)recreational activities in the community. The individuals performed the 6-minute walk test (6MWT), Beck Depression Inventory (BDI), han-dgrip strength (HGS), and the COPD Assessment Test (CAT). The comparison between older adults who participate in formal and informalorganizations was made using the Student’s T-Test. Results: 77% of COPD patients participated in religious or spiritual groups and 74% in activities with family and friends. Womenparticipated more in informal (P=0.002) and formal (P=0.004) social activities than men. Individuals who have participated in socialactivities were those who had lower performance in 6MWT and higher scores in BDI and CAT (P<0.05 for all). Conclusions: The social participation of older adults with COPD is greater in religious groups, family activities and with friends.Additionally, older adults who participate in community organizations are those who have more functional and emotional limitations.This reinforces the role of community groups to support older adults with COPD who have some health limitation.(AU)

Bilateral, single-session, laparoscopic adrenalectomy was associated with favorable outcomes in a cohort of dogs.

OBJECTIVE: To report perioperative characteristics and outcome following bilateral, single-session, laparoscopic adrenalectomy (BSSLA) in dogs. ANIMALS: Client-owned dogs (n = 6). CLINICAL PRESENTATION AND PROCEDURES: Medical records were reviewed and perioperative data collected, including preoperative diagnostic imaging, operative details, complications, and need for conversion to open laparotomy. Bilateral, single-session, laparoscopic adrenalectomy was performed on the right or left side with a standard 3- or 4-portal transperitoneal technique. The dog was repositioned to contralateral recumbency, and laparoscopic adrenalectomy was repeated. Follow-up information was collected by telephone interviews with the owners and/or referring veterinarian. RESULTS: Median age and weight of dogs were 126 months and 14.75 kg, respectively. Contrast-enhanced CT (CECT) was performed in all dogs. Median maximal tumor diameter was 2.6 and 2.3 cm for the right and left-sided tumors, respectively. Median surgical and anesthesia times were 158 and 240 minutes, respectively. Conversion to open laparotomy was performed in 1 dog following renal vein laceration during initial adrenalectomy. Left adrenalectomy and ureteronephrectomy were performed, and the right adrenal tumor was left in situ. Cardiac arrest occurred in 1 dog following initial adrenalectomy (left); however, the dog was resuscitated successfully, and contralateral laparoscopic adrenalectomy was performed without complication. All dogs survived to hospital discharge. Follow-up ranged from 60 to 730 days (median, 264 days) for dogs that successfully underwent BSSLA. CLINICAL RELEVANCE: BSSLA was associated with favorable outcomes in this cohort of dogs. Laparoscopy may be considered in dogs with bilateral, modestly sized, noninvasive adrenal tumors.

Effectiveness of Respiratory Muscles Training by Voluntary Isocapnic Hyperpnea Versus Inspiratory Threshold Loading on Intercostales and Vastus Lateralis Muscles Deoxygenation Induced by Exercise in Physically Active Adults.

Respiratory muscle training (RMT) improves physical performance, although it is still debated whether this effect depends on the type of training. The purpose of this study was to compare the effects of two different types of RMT, i.e., voluntary isocapnic hyperpnea (VIH) and inspiratory threshold loading (ITL), on the deoxygenation of intercostal (ΔSmO2-m. intercostales) and vastus lateralis (ΔSmO2-m. vastus lateralis) muscles during exercise. Twenty-four participants performed eight weeks of RMT by: (i) VIH (3 days·week-1 for 12 min at 60% maximal voluntary ventilation) or (ii) ITL (5 sets·week-1 of 30 breaths·minute-1 at 60% maximal inspiratory pressure). Cardiopulmonary exercise testing (CPET) included ΔSmO2 (the change from baseline to end of test) of intercostal and vastus lateralis muscles. After RMT, both groups showed decreased ΔSmO2-m. intercostales (VIH = 12.8 ± 14.6%, p = 0.04 (effect size, ES = 0.59), and ITL = 8.4 ± 9.8%, p = 0.04 (ES = 0.48)), without a coincident change of ∆SmO2-m. vastus lateralis. ITL training induced higher V˙O2-peak absolute values than VIH (mean Δ post-pre, ITL = 229 ± 254 mL·min-1 [95% CI 67-391] vs. VIH, 39 ± 153 mL·min-1 [95% CI -58-136.0], p = 0.01). In conclusion, both RMT improved the balance between supply and oxygen consumption levels of m. intercostales during CPET, with ITL also inducing an increase of aerobic capacity.

Efectividad de adicionar elongación de la cápsula posterior a un programa de ejercicios en pacientes con síndrome de pinzamiento subacromial: estudio clínico aleatorizado / Effectiveness of adding posterior capsule stretching after an exercise program in patients with subacromial impingement syndrome: a randomized clinical study

Objetivo: Determinar la efectividad clínica de adicionar el ejercicio de elongación de “estiramiento acostado” a un programa de ejercicios específicos en pacientes con síndrome de pinzamiento subacromial (SPSA). Diseño: Estudio clínico aleatorizado ciego simple. Método: Se reclutaron en forma prospectiva 64 pacientes con diagnóstico clínico e imagenológico de SPSA, quienes fueron asignados a dos grupos al azar. El grupo control (n = 32) recibió un programa de ejercicios de 12 semanas, el grupo de intervención (n = 32) recibió el mismo programa más un ejercicio de elongación de la cápsula posterior. Ambos grupos fueron evaluados al inicio y al finalizar el tratamiento. La medida de resultado primaria fue la función del hombro con el cuestionario Constant-Murley, las medidas de resultado secundarias fueron la función de la extremidad superior con el cuestionario DASH y el dolor en reposo y al movimiento con la escala visual analógica (EVA).Resultados: Todos los pacientes completaron el estudio. Al finalizar el tratamiento el cuestionario Constant-Murley mostró una diferencia de 3 puntos (p = 0.864) y el cuestionario DASH una diferencia fue de 2 puntos (p = 0.941), ambas diferencias son a favor del grupo de intervención, pero no son ni clínica ni estadísticamente significativas. Para la EVA en reposo la diferencia fue de 0,2 cm (p = 0,096) y la EVA al movimiento fue de 0,4 cm (p = 0,378), en ambas la diferencia en la reducción del dolor fue mayor en el grupo control. Conclusión: A corto plazo, adicionar el ejercicio de “estiramiento acostado” no proporciona un beneficio clínico ni estadísticamente significativo con respecto a la mejora funcional o la reducción del dolor en pacientes con SPSA.(AU)

Objective: To determine the clinical effectiveness of adding the exercise of “sleep-stretch” to a specific exercise program in patients with subacromial impingement syndrome (SIS). Design: Randomized controlled trial, single-blinded. Methods: Sixty-four patients with clinical and imagenologic diagnosis of SIS were prospectively recruited, who were randomly allocated to two groups. The control group (n = 32) received a 12-week exercise program, and intervention group (n = 32) received the same program plus stretching of the posterior capsule. Both groups were assessed at baseline and at the end of the treatment. The primary outcome measure was shoulder function assessed with Constant-Murley questionnaire. Secondary outcomes measures were upper limb function assessed with the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, and pain at rest and movement with visual analog scale (VAS). Results: All patients completed the trial. At the end of the treatment, Constant-Murley questionnaire showed a difference of 3 points (p = 0.864), and the DASH questionnaire a difference was 2 points (p = 0.941), both differences were in favor of the intervention group, but they are neither clinically or statistically significant. For the VAS at rest the difference was 0.2 cm (p = 0.096) and the VAS at movement was 0.4 cm (p = 0.378), both differences in pain reduction was greater in the control group.Conclusion: In the short term, the addition of a “sleep-stretch” exercise does not provide a clinically or statistically significant benefit with respect to functional improvement or pain reduction in patients with SIS.(AU)

Modeling the spread of COVID-19 on construction workers: An agent-based approach.

As the spread of COVID-19 has continued since December 2019, stay at home orders around the globe have changed how we live our lives, mostly from physical to virtual interactions, such as going to college and doing our jobs; however, some activities are basically impossible to perform virtually, such as construction activities. Thus, the construction sector has been highly disrupted by the current pandemic. The construction sector represents a key component of countries' economies-it is approximately 13% of global GDP-as such, having the availability to perform construction activities with a minimum spread of COVID-19 may help to the financial response to the pandemic. Given this context, this study aims to understand the potential impact of COVID-19 on construction workers using an agent-based modeling approach. Activities are classified as being of low-medium-high risk for workers, and the spread of COVID-19 is simulated among construction workers in a project. This study found that the workforce from a construction project may be reduced by 30% to 90% due to the spread of COVID-19. Understanding how COVID-19 may spread among construction workers may assist construction project managers in creating adequate conditions for workers to perform their job, minimizing the chances of getting infected with COVID-19.

Evaluation of transanal minimally invasive surgery for submucosal rectal resection in cadaveric canine specimens.

OBJECTIVE: To evaluate the feasibility of transanal minimally invasive surgery (TAMIS) for submucosal rectal resection in large breed dogs. STUDY DESIGN: Cadaveric study. SAMPLE POPULATION: Canine cadavers (n = 6) weighing between 37.5 and 60 kg. METHODS: Dogs were positioned in sternal recumbency. After rectal cleansing, a transanal access platform was placed in the rectum, and a pneumorectum was established. An area of ventral rectal wall approximately 2 × 2 cm was resected in a submucosal plane by using laparoscopic instruments and submitted for histopathological evaluation. The rectal wall defect was closed with a single-layer continuous suture pattern with barbed suture. Postoperatively, the rectum was removed en bloc and evaluated for suture or surgical penetration of the serosal surface. RESULTS: Submucosal rectal resection was successfully completed by using TAMIS in all dogs. The median length of resected specimens after fixation was 24.5 mm (range 9.8-26.5). In two of six dogs, suture was macroscopically visible on the serosal surface, but no dogs had evidence of iatrogenic full-thickness surgical penetration of the rectum. The median distance from the aborad extent of the suture closure line to the anocutaneous junction was 35 mm (range, 35-105). CONCLUSION: Submucosal resection of the canine rectal wall was feasible in large breed dogs by using TAMIS. No evidence of full-thickness penetration of the rectal wall was seen in these cadaveric specimens. CLINICAL SIGNIFICANCE: Transanal minimally invasive surgery may provide an alternative minimally invasive approach for resection for benign adenomatous rectal polyps in large breed dogs that might otherwise require a rectal pull-through.

Perfil facial blando y relación distal de segundos molares en niños con dentición primaria completa / Soft facial profile and distal relation of second molars in children with complete primary dentition

Objetivo.Evaluar los tipos de perfil facial blando mediante los ángulos de convexidad facial (ACF) y convexidad facial total (ACFT) y su relación con la posición distal de los segundos molares primarios en niños entre 3 y 5 años. Métodos. Estudio transversal en 28 niños chilenos con al menos un apellido de origen español y dentición primaria completa, quienes cumplían con los requisitos del estudio. Para evaluar el ACF y ACFT se tomó fotografía digital estandarizada del perfil lateral. Con la prueba exacta de Fisher se comparó los perfiles blandos según edad y género, y con t de Student para muestra única se evaluó los promedios angulares. Resultados. Para el ACF la media fue 167,1° ± 5,1, y para ACFT 145,8° ± 3,7. Se observó convexidad alta del ACF en 21,4% de los niños, media en 60,7% y baja en 17,9%; y para el ACFT en 17,9%, 67,9% y 14,2% res-pectivamente. El promedio del ACF para la relación molar escalón mesial, plano vertical y escalón distal fue de 169,2° ± 3.7, 168° ± 4,9 y 162,5°±4,8, mientras que para ACFT fue 146,7° ± 4,4, 146,3° ± 3,6 y 143,5° ± 2,8 respectivamente. Conclusiones. Se observó para ACF relación significativa entre la presencia de perfil convexo alto y escalón distal, además de diferencia significativa entre el promedio de este ángulo en escalón distal en comparación al promedio de referencia. El ACF puede ser indicador aceptable de escalón distal, sin embargo, no es certero al evaluar un plano vertical o escalón mesial. Palabras clave: Cefalometría; Preescolar; Fotografía; Dentición (fuente: DeCS Bireme).

Objetive. To observe the types of soft facial profile according to the angles of facial convexity (FCA) and total facial convexity (TFCA), in addition to evaluating their rela-tionship with the distal position of the primary second molars in children between 3 and 5 years. Methods. Twenty-eight out of 200 children with complete primary dentition were examined to determine the distal relation of primary second molars, and a digital photographic examination of their lateral profile was performed to evaluate the ACF and ACFT. With the Fisher's exact test, soft tissue profiles were compared according to age and gender, and with Student t test for a single sample, the angular averages were evaluated. Results. The mean of the FCA was 167.1 ° ± 5.1, and the TFCA was 145.8 ° ± 3.7. A high convexity of the FCA was observed in 21.4% of the children, medium in 60.7% and low in 17.9%. While in the TFCA it was divided into 17.9% with high convexity, 67.9% medium and 14.2% low. The average value of the FCA for the mesial step, flush terminal and distal step 169.2 ° ± 3.7, 168 ° ± 4.9 and 162.5 ° ± 4.8, while the average of the TFCA was 146.7 ° ± 4.4, 146.3 ° ± 3.6 and 143.5 ° ± 2.8 respectively. Conclusions. A significant relationship between the presence of a high convex profile and a distal step molar relationship was observed for the FCA, as well as a significant difference between the average of this angle in distal step compared to the reference average. Keywords: Cephalometry; Child preschool; Photography; Tooth Deciduous (source: MeSH NLM).

Prevalencia de anomalías dentomaxilares en dentición primaria y mixta primera fase en la Facultad de Odontología de la Universidad de Chile, 2018 / Prevalence of dentomaxillary anomalies in primary and mixed first phase dentition in the Faculty of Dentistry of the University of Chile, 2018

Objetivo.El presente estudio tuvo como objetivo analizar la prevalencia de las anomalías dentomaxilares en niños de 3 a 10 años que solicitaron atención en la Facultad de Odon-tología de la Universidad de Chile en el año 2018. Métodos. Se realizó un estudio des-criptivo y de tipo transversal, donde el universo correspondió a los pacientes atendidos en la UTE (Unidad de Trabajo del Estudiante) Clínica del niño y adolescente de 4to año de la Facultad de Odontología de la Universidad de Chile. Cohorte 2018. Para la evaluación de anomalías dentomaxilares se consideró la Clasificación Biogenética de Bonn Modificada. Anomalías intermaxilares. Resultados. Del total de la muestra analizada (n: 106), el 45,1% de los pacientes presentaron alteraciones de tipo transversal, vertical y/o sagital. Conclusiones. La anomalía transversal más prevalente fue la mordida cruzada unilateral. La anomalía vertical más prevalente fue la sobremordida. Las anomalías sagitales más prevalente fueron las distoclusiones y la mordida invertida simple. Palabras clave: Niño; Maloclusión; Ortodoncia (fuente: DeCS BIREME).

Objetive. The present study aimed to analyze the prevalence of dentomaxillary anomalies in children aged 3 to 10 years old who requested attention at the Faculty of Dentistry of the University of Chile in the year 2018. Methods. A descriptive and cross-sectional study was carried out, where the universe corresponded to the patients attended in the SWU (Student Work Unit) of the Child and Adolescent Clinic of the 4th year of the Faculty of Dentistry of the University of Chile. Cohort 2018. For the evaluation of dentomaxillary anomalies, the Modified Bonn Biogenetic Classification was considered. Intermaxillary abnormalities. Results. Of the total sample analyzed (n: 106), 45.1% of the patients presented transverse, vertical and/or sagittal type alterations. Conclusions. The most prevalent transversal anomaly was the unilateral cross bite. The most prevalent vertical anomaly was the deep bite. The most prevalent sagittal anomalies were the distoclusions and the simple Inverted bite. Keywords: Child; Malocclusion; Orthodontics (Source: MeSH NLM).

Linfoma testicular: incidencia, descripción epidemiológica y manejo durante el período 2005-2011 / Testicular lymphoma: incidence, epidemiologic description and management during the 2005-2011 period

El linfoma testicular es una patología infrecuente, correspondiendo al 9 por ciento de los cánceres testiculares, presentándose más frecuentemente entre los 60 a 80 años (25-50 por ciento). La presentación clínica más frecuente es el aumento de volumen unilateral e indo/oro. El tipo histológico más común es linfoma difuso de células grandes B (60-90 por ciento). La orquidectomía radical asociada a quimioterapia y radioterapia es la primera línea de tratamiento para los pacientes con enfermedad limitada. Material y método: Estudio retrospectivo descriptivo. Se revisó y filtró la lista de pacientes ingresados al SIGGES como tumor testicular entre enero 2005 a abril 2011. De los pacientes con diagnóstico histológico e inmunohistoquímico compatible, se registraron las características epidemiológicas, estudio, manejo y sobrevida. Posteriormente se realizó un análisis de la base de datos con el programa estadístico SPSS 13. 0. Resultados: De un total de 299 pacientes con el diagnóstico histológico de cáncer testicular, 8 pacientes fueron diagnosticados como linfoma testicular confirmado por histología e inmunohistoquímica. El promedio y mediana de edad fue 52 años y 63 años (18-73) respectivamente. Tres casos (37,5 por ciento) correspondieron a presentaciones secundarias. En 6 de los casos (75 por ciento) el testículo afectado fue el derecho. Histológicamente, el 63 por ciento correspondió a Linfoma difuso de células grande B. Clínicamente, el todos los casos se presentaron con aumento de volumen y con marcadores en rango normal. En 7 casos (8 7, 5 por ciento) el diagnóstico y manejo inicial fue mediante orquidectomía radical, y en un caso por biopsia testicular, con orquidectomía posterior 3 casos presentaron diseminación...

esticular lymphoma is a rare disease, happening in 9 percent of testicular cancers, most commonly between the ages 60 to 80 years (25 percent-50 percent). The most common presentation is unilateral indolent testicular growth. Histology shows a diffuse big B cell lymphoma in most of the cases (60 percent-90 percent). Radical orchiectomy, chemotherapy and radiation are the first line therapy for patients with limited disease. Materials and methods: Retrospective clinical study. We included and filtered the SIGGES list of patients admitted for Testicular Tumor from January 2005 to April 2011. Patients with a compatible diagnosis were analyzed, using SPSS 13.0® as statistical software. Result: Of a total number of 299 testicular cancer patients 8 presented with a histological and inmunnohistochemical testicular lymphoma. Mean age was 52 years and the median 63 years (18-73). ln three cases (37.5 percent) it was a secondary localization. ln 6 cases ( 75 percent) the affected testicle was the right one. 63 percent corresponded to a diffuse big cell B cell Lymphoma. All patients presented normal tumor markers. ln 7 (87,5 percent) cases the initial treatment was radical orchiectomy in one patient the diagnosis was don through a testicular biopsy, and the orchidectomy was differed. 3 cases presented dissemination. In 7 patients adjuvant chemotherapy was performed. Mortal/ty was 38 percent with a 1 7-month follow-up. Conclusion: Testicular lymphoma is a rare condition with bad prognosis. Histology is fundamental for treatment, an in this sense inmunohystochemcal analysis is especially helpful...

[Analysis of mortality due to laryngeal cancer in Chile (1994-2004)]. / Análisis de la mortalidad por cáncer laríngeo en Chile (1990-2004).

INTRODUCTION AND OBJECTIVES: Laryngeal cancer is the second most common respiratory cancer worldwide. In Chile, national registries of cancer incidence do not exist, only mortality statistics are available. The aim of this study is to analyze the trends in mortality rates from laryngeal cancer in Chile, during the period between 1990 and 2004, and its distribution by sex and age. MATERIAL AND METHOD: The totalities of the deaths caused by laryngeal cancer were selected from the official mortality databases (1990-2004), and the projections of population elaborated by the National Statistics Institute were used for the calculation of age- and sex-adjusted mortality rates. RESULTS: In Chile, during the period studied a total of 1842 deaths caused by laryngeal cancer occurred, of which 85.78 % corresponded to men and 14.22 % to women. The crude and adjusted incidence rates were 0.90 and 0.82 per 100 000 inhabitants, respectively. They were greater in men, increased progressively with age, and diminished over time throughout the period studied. CONCLUSION: Laryngeal cancer in Chile presented a constant decline over the period studied. Sex- and age-distributions were similar to international data. A substantial part of this decline could be explained by the increase in mortality from other causes and by therapeutic and diagnostic improvements.

Análisis de la mortalidad por cáncer laríngeo en Chile (1990-2004) / Analysis of mortality due to laryngeal cancer in Chile (1994-2004)

Introducción y objetivos: El cáncer de laringe es el segundo tumor maligno del aparato respiratorio más frecuente en el mundo. En Chile no existen registros nacionales de la incidencia de cáncer, sólo se dispone de cifras oficiales de mortalidad. El objetivo de este trabajo es analizar la tendencia de las tasas de mortalidad por cáncer laríngeo en Chile, durante el período comprendido entre los años 1990 y 2004, y su distribución por sexo y edad. Material y método: Se seleccionó la totalidad de las muertes por cáncer laríngeo registradas en la base de datos oficiales de mortalidad (1990-2004). Se utilizaron las proyecciones de población elaboradas por el Instituto Nacional de Estadística para el cálculo de tasas de mortalidad bruta y ajustada por sexo y edad. Resultados: En Chile, durante el período estudiado hubo 1.842 defunciones por cáncer laríngeo, de las que el 85,78 % correspondió al sexo masculino y el 14,22 %, al sexo femenino. Las tasas de mortalidad específicas para cáncer laríngeo brutas y ajustadas por sexo y edad fueron, respectivamente, 0,90 y 0,82/100.000 habitantes, mayores entre los varones, aumentando progresivamente con la edad y disminuyendo durante el período estudiado. Conclusiones: El cáncer laríngeo en Chile presentó una disminución constante en el período estudiado. La distribución por sexo y edad fue similar a lo comunicado internacionalmente. Parte sustancial de esta reducción podría atribuirse al aumento de la mortalidad por otras causas y la mejora de los métodos diagnósticos y terapéuticos

Introduction and objectives: Laryngeal cancer is the second most common respiratory cancer worldwide. In Chile, national registries of cancer incidence do not exist, only mortality statistics are available. The aim of this study is to analyze the trends in mortality rates from laryngeal cancer in Chile, during the period between 1990 and 2004, and its distribution by sex and age. Material and method: The totalities of the deaths caused by laryngeal cancer were selected from the official mortality databases (1990-2004), and the projections of population elaborated by the National Statistics Institute were used for the calculation of age- and sex-adjusted mortality rates. Results: In Chile, during the period studied a total of 1842 deaths caused by laryngeal cancer occurred, of which 85.78 % corresponded to men and 14.22 % to women. The crude and adjusted incidence rates were 0.90 and 0.82 per 100 000 inhabitants, respectively. They were greater in men, increased progressively with age, and diminished over time throughout the period studied. Conclusion: Laryngeal cancer in Chile presented a constant decline over the period studied. Sex- and age-distributions were similar to international data. A substantial part of this decline could be explained by the increase in mortality from other causes and by therapeutic and diagnostic improvements