ABSTRACT
We describe a case in which vaginal bleeding has represented the onset symptom of a renal clear cell adenocarcinoma. A 53-year-old patient presented with a bleeding polypoid neoformation of the vaginal forewall for which exeresis was immediately decided for diagnostic and curative purpose. An attentive histological examination was immediately addressed towards the renal origin. Afterwards the search and image staging (abdominal and pelvic ultrasound examination, urography, abdominal and cerebral TAC) has allowed us to confirm the presence of a tumor of the left kidney and audit that the secondary vaginal location to the moment was probably the only manifestation of the illness. Left nephrectomy with complementary associated lymphoadenectomy joined to the auxiliary therapy with progestin and interferone has allowed us to decidedly improve the subjective and general conditions of the patient.