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1.
Cureus ; 15(2): e34588, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36883074

ABSTRACT

Hepatocellular carcinoma (HCC) has an affluent blood supply stemming from the hepatic artery. Subsequent spontaneous tumor rupture can lead to massive abdominal hematoma and shock, a rare fatal gastrointestinal incident. The diagnosis of rupture is complicated, with most patients presenting with abdominal pain and shock. Prompt correction of hypovolemic shock is the primary goal of treatment. This rare case presents a 75-year-old male who presented to the emergency department because of abrupt and increasing abdominal pain after a meal. Laboratory data revealed elevated alanine aminotransferase, aspartate aminotransferase, and alpha-fetoprotein levels. Immediate computed tomography demonstrated a defect in the right ventral abdominal wall. The patient underwent an emergency exploratory laparotomy. Despite massive intra-abdominal adhesions, the identified source of bleeding was from the left lobe of the liver at the base of the lesser sac above the pancreas. There was a maximum effort to cease bleeding and minimize blood loss. An ensuing biopsy of the liver revealed HCC. After improving, the patient received instructions to follow up on an outpatient basis. Two months after surgery, the patient endorses no complications. The success outlined in this case highlights the essence of prompt action in an emergency, which delineates the significance of surgical experience in handling unorthodox patient presentations.

2.
J Thromb Thrombolysis ; 41(3): 505-10, 2016 Apr.
Article in English | MEDLINE | ID: mdl-26407682

ABSTRACT

Thrombelastography (TEG) measures coagulation in venous blood. We hypothesized that TEG, by reflecting clot subtype and ex vivo fibrinolysis, might predict fibrinolytic response to tPA as reflected by rapid clinical improvement or hemorrhagic transformation of the infarct. 171 acute ischemic stroke patients treated with tPA were prospectively enrolled. Venous blood for TEG was drawn before and 10 min after tPA bolus. We measured rapid clinical improvement (RCI = 8 point improvement on NIHSS or total NIHSS of 0, 1 at 36 h), Hemorrhagic transformation (HT = any blood on imaging within 36 h), and hyperdense middle cerebral artery sign (HDMCA = biomarker for erythrocyte-rich clot). Multivariable regression models compared TEG parameters after adjusting for potential confounders. No differences in pre- or post-tPA TEG were found between patients with or without RCI. Also, there was no correlation between TEG and HDMCA. Clotting was slightly prolonged in patients with HT (p = 0.046). We failed to find a robust association between TEG and clinical response to tPA. It is likely that arterial clot lysis is determined by factors unrelated to coagulation status as measured by TEG in the venous circulation. It is unlikely that TEG will be useful to predict clinical response to tPA, but may help predict bleeding.


Subject(s)
Brain Ischemia , Models, Biological , Stroke , Thrombelastography , Tissue Plasminogen Activator/administration & dosage , Acute Disease , Brain Ischemia/blood , Brain Ischemia/drug therapy , Female , Hemorrhage/blood , Hemorrhage/chemically induced , Humans , Male , Predictive Value of Tests , Prospective Studies , Stroke/blood , Stroke/drug therapy , Tissue Plasminogen Activator/adverse effects
3.
Ann Clin Lab Sci ; 45(3): 301-7, 2015.
Article in English | MEDLINE | ID: mdl-26116594

ABSTRACT

OBJECTIVE: Platelet reactivity may be important in the management of patients with stroke. However, degree of platelet reactivity has not been correlated with Thrombelastography (TEG(®)) parameters in stroke. We sought to detect a correlation between TEG(®) values and clot platelet reactivity in ex vivo clots of stroke patients. METHODS: We collected venous blood from 40 patients with stroke. TEG(®) measurements were carried out and residual clots were fixed in 10% formalin immediately following completion of TEG(®). The formalin specimens were embedded in paraffin blocks, cut at 4 micrometers, and stained with CD 61 (immunohistochemical stain used to detect platelets) with appropriate controls. Under light microscopy, three pathologists blinded to TEG(®) results independently graded CD61 intensity (how aggregated/intense the CD61 stained) into a low and high group, as a proposed measurement representing the platelet reactivity of the clot. We compared pre-tPA-TEG(®) values among groups with different CD 61 intensities. RESULTS: After adjusting for confounding factors, we found statistically significant correlation between CD61 staining and several TEG(®) parameters (Delta and CD61 staining intensity (p=0.047); Angle and CD61 staining intensity grade (p=0.04); and G and CD61 staining intensity grade (p=0.04)). CONCLUSIONS: Clot strength on TEG(®) as measured by Delta, Angle, and G correlates with a clot with greater platelet reactivity.


Subject(s)
Blood Coagulation , Blood Platelets/pathology , Stroke/blood , Thrombelastography/methods , Aged , Confidence Intervals , Demography , Female , Humans , Immunohistochemistry , Male , Middle Aged
4.
Stroke ; 45(3): 880-3, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24425115

ABSTRACT

BACKGROUND AND PURPOSE: Factor Xa inhibitors are prescribed for stroke prevention in atrial fibrillation. Managing such patients is challenging especially if they are eligible for thrombolysis because there is no rapidly available test to detect the effect of such medications. Thrombelastography analyzes the dynamics of coagulation and can be rapidly performed. We sought to determine whether thrombelastography can detect the anticoagulation effect of factor Xa inhibitors in patients with stroke. METHODS: Blood from 10 patients with stroke was analyzed by thrombelastography at baseline and 2 to 18 hours after rivaroxaban administration. RESULTS: Increased R, K, and δ were seen at 2, 4, and 6 hours, while G, maximum amplitude, α-angle, and LY30 were decreased. Baseline R was 5.8±0.5 when compared with 11.4±1.0 at 2 hours. R remained prolonged at 18 hours. Other thrombelastography parameters were normal by 18 hours. CONCLUSIONS: Thrombelastography can detect the anticoagulant effect of factor Xa inhibitors in patients with stroke and might be useful in the emergency management of those eligible for thrombolysis.


Subject(s)
Anticoagulants/therapeutic use , Morpholines/therapeutic use , Stroke/blood , Thiophenes/therapeutic use , Thrombelastography/methods , Aged , Blood Coagulation/drug effects , Factor XI/antagonists & inhibitors , Female , Humans , Male , Middle Aged , Rivaroxaban , Stroke/drug therapy , Thrombelastography/statistics & numerical data , Thrombolytic Therapy/methods
5.
Stroke ; 45(3): 683-8, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24425123

ABSTRACT

BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) has high morbidity, and hematoma enlargement (HE) causes worse outcome. Thrombelastography (TEG) measures the dynamics of clot formation and dissolution, and might be useful for assessing bleeding risk. We used TEG to detect changes in clotting in patients with and without HE after ICH. METHODS: This prospective study included 64 patients with spontaneous ICH admitted from 2009 to 2013. TEG was performed within 6 hours of symptom onset and after 36 hours. Brain imaging was obtained at baseline and at 36±12 hours, and HE was defined as total volume increase>6 cc or >33%. TEG was also obtained from 57 controls. RESULTS: Compared with controls, patients with ICH demonstrated faster and stronger clot formation; shorter R and delta (P<0.0001) at baseline; and higher MA and G (P<0.0001) at 36 hours; 11 patients had HE. After controlling for potential confounders, baseline K and delta were longer in HE+ compared with HE- patients, indicating that HE+ patients had slower clot formation (P<0.05). TEG was not different between HE+ and HE- patients at 36 hours. CONCLUSIONS: TEG may detect important coagulation changes in patients with ICH. Clotting may be faster and stronger in immediate response to ICH, and a less robust response may be associated with HE. These findings deserve further investigation.


Subject(s)
Blood Coagulation Disorders/diagnosis , Cerebral Hemorrhage/diagnosis , Thrombelastography/methods , Aged , Blood Coagulation Disorders/complications , Cerebral Hemorrhage/complications , Clopidogrel , Data Interpretation, Statistical , Female , Hematoma/pathology , Humans , Male , Middle Aged , Platelet Aggregation Inhibitors/adverse effects , Platelet Aggregation Inhibitors/therapeutic use , Prospective Studies , Sample Size , Socioeconomic Factors , Thrombolytic Therapy , Ticlopidine/adverse effects , Ticlopidine/analogs & derivatives , Ticlopidine/therapeutic use
6.
Stroke ; 45(2): 462-6, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24370757

ABSTRACT

BACKGROUND AND PURPOSE: Iodinated contrast agents used for computed tomography angiography (CTA) may alter fibrin fiber characteristics and decrease fibrinolysis by tissue plasminogen activator (tPA). Thromboelastography (TEG) measures the dynamics of coagulation and correlates with thrombolysis in acute ischemic stroke patients. We hypothesized that receiving CTA before tPA will not impair thrombolysis as measured by TEG. METHODS: Acute ischemic stroke patients receiving 0.9 mg/kg tPA <4.5 hours of symptom onset were prospectively enrolled. For CTA, 350 mg/dL of iohexol or 320 mg/dL of iodixanol at a dose of 2.2 mL/kg was administered. TEG was measured before tPA and 10 minutes after tPA bolus. CTA timing was left to the discretion of the treating physician. RESULTS: Of 136 acute ischemic stroke patients who received tPA, 47 had CTA before tPA bolus, and 42 had either CTA after tPA and post-tPA TEG draw or no CTA (noncontrast group). Median change in clot lysis (LY30) after tPA was 95.3% in the contrast group versus 95.0% in the noncontrast group (P=0.74). Thus, tPA-induced thrombolysis did not differ between contrast and noncontrast groups. Additionally, there was no effect of contrast on any pre-tPA TEG value. CONCLUSIONS: Our data do not support an effect of iodinated contrast agents on clot formation or tPA activity.


Subject(s)
Blood Coagulation/drug effects , Brain Ischemia/diagnosis , Contrast Media/adverse effects , Iohexol/adverse effects , Stroke/diagnosis , Thrombelastography/methods , Triiodobenzoic Acids/adverse effects , Aged , Angiography , Brain Ischemia/blood , Cohort Studies , Data Collection , Female , Fibrinolytic Agents/therapeutic use , Humans , Male , Middle Aged , Regression Analysis , Stroke/blood , Thrombolytic Therapy , Tissue Plasminogen Activator/therapeutic use , Tomography, X-Ray Computed
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