[Quality of life two years after myocardial infarction. 1. Examination questionnaires]. / Jakosc zycia chorych w dwa lata po zawale miesnia serca. 1. Kwestionariusz do badan.

The purpose of the present study was to assess the quality of life (QOL) and factors influencing QOL in patients 2 years after myocardial infarction (MI). The study was performed in 100 pts (mean age 45.5) mean 2 years after MI. 50 pts of studied group (mean age 42.5) were resuscitated from ventricular fibrillation (VF) complicating acute phase of MI. The control group consisted of 100 healthy subjects persons (mean age 53.5). The QOL index was assessed with the use of 2 types questionnaires: "Quality of Well-Being Scale" (QWB) and questionnaires of QOL including 26 factors in terms of: pain, dyspnoea, anxiety, depression, energy, sleep, emotions, mobility, social isolation, sexual activity, hobby, subjective emotional, distress, functional and social state and return to work. The QOL index was assessed using mathematical Krefft method. The average value of QOL index in patients 2 years following MI was significantly lower when compared with control group. The mathematical method of Krefft showed, that out of 26 features the most important diagnostic power factor for the QOL index were: self estimation of physical performance, return to work, the lifestyle and presence of stenocardial pain and dyspnoea. The pts resuscitated from VF revealed the higher level of anxiety.

[Quality of life two years after myocardial infarction. 2. Examination of affecting factors]. / Jakosc zycia chorych w dwa lata po zawale miesnia serca. 2. Ocena wplywu czynników.

This study aimed at determining these factors--ventricular fibrillation (VF) in acute phase of myocardial infarction MI), thrombolytic therapy, beta-blockers after MI, cardiac rehabilitation--affect quality of life (QOL) during the follow-up. The study involved 100 patients (mean age 45.5 years), on the average 2 years after MI, MI has complicated VF in 50 patients. Questionnaire of QOL after MI developed internally, taking into account 26 features (clinical, emotional and social status), and estimating anxiety level (STAI) were used. Computer medical diagnostics "SyntMED" (Krefft's method) was used. In both groups after MI (complicated and not complicated VF) beneficial effect of: thrombolytic treatments in acute phase MI (0.65 vs conventional 0.45, p > 0.05), use of beta-blockers after MI (0.56 vs 0.41 p < 0.05), and cardiac rehabilitation (0.64 vs 0.44 p < 0.05) on value QOL were noted. Patients after MI complicated VF had higher level of anxiety. Patients who returned to work had higher index QOL (0.62 vs 0.39). Ventricular fibrillation complicated the acute phase of MI had no significant effect on follow-up QL.

Pathology and ultrastructural characteristics of a hypomelanotic variant of transplantable hamster melanoma with elevated tyrosinase activity.

A spontaneous, hypomelanotic variant (MI) of the highly melanotic transplantable hamster melanoma of Bomirski (Ma) is the subject of this report. Tyrosinase activity is 2-3 times higher, but melanin content significantly lower than in the parental Ma melanotic melanoma. Acid phosphatase activity is similar in both, but beta-glucuronidase and aryl-sulfatase A are 2-3 times higher in the hypomelanotic variant. Transplanted MI melanomas grow more slowly than the parental tumor, but metastasize with similar incidence and localization. Hypomelanotic variant melanoma cells, even those in grossly nonnecrotic parts of the transplants, show signs of low viability like swelling of the cytoplasm or cellular condensation, and disintegration. Autophagic vacuoles are numerous. They appear to be formed by enclosure of a portion of cytoplasm by cisternae of smooth endoplasmic reticulum or trans-Golgi network. These limiting cisternae contain tyrosinase as evidenced by deposition of electron dense reaction product on incubation with tyrosine or DOPA. Other sites of ultrastructural tyrosinase reaction are melanosomes and the smooth-surfaced cisternae and vesicles of the trans-Golgi network. We postulate the low cell viability, associated with autophagosome formation, is the cause for the growth retardation of the MI variant, and that the lower melanin content of these tyrosinase-rich cells is due to sequestration of a substantial portion of newly synthesized enzyme into autophagic vacuoles before it has the chance of being incorporated into melanosomes.

Effect of tissue selection on melanization of MI hamster melanoma.

Selection of the most melanized tissue of the slightly melanotic MI melanoma in hamster resulted in an origin of a new highly melanotic tumor line. It differed from the parental MI melanoma in the 5-fold higher melanin content, but its tyrosinase activity, growth rate and histological structure remained unchanged. Selection of the least melanotic tissue of the MI melanoma did not give positive results.