ABSTRACT
INTRODUCTION: The number of consultations for sexually transmitted infections (STIs) is increasing in Spain. The aim of this study was to describe and analyze the epidemiological, behavioral, clinical, and microbiological characteristics of patients registered at the STI unit of a tertiary hospital. METHODS: This was a retrospective, single-center descriptive study carried out between 2010 and 2013 in a multidisciplinary unit specialized in STIs, situated in a tertiary hospital. Epidemiological, clinical, and behavioral data were gathered using a face-to-face interview and a standardized questionnaire. Samples were collected for microbiology analysis. RESULTS: The study included 546 patients: 96% were men, 41% had human immunodeficiency virus (HIV) infection, and 56% were men who have sex with men. The reasons for consultation were the following: urethritis; genital, anal, or perianal ulcers; proctitis; oral ulcers; sexual contact with a person with a known STI; and high-risk sexual contact. The most common microbiological diagnoses were Neisseria gonorrhoeae in urethritis, Treponema pallidum in genital and anal or perianal ulcers, and Chlamydia trachomatis lymphogranuloma venereum serovars in proctitis. The highest prevalences of the main STIs studied occurred in homosexual men with HIV infection. CONCLUSION: This study confirms the increase in the incidence of STIs in recent years and the epidemiological characteristics of the HIV/STI epidemic in Spain.
Subject(s)
Sexually Transmitted Diseases/epidemiology , Tertiary Care Centers , Chlamydia Infections/epidemiology , Female , Gonorrhea/epidemiology , HIV Infections/epidemiology , Homosexuality , Humans , Male , Retrospective Studies , Risk Factors , Sexually Transmitted Diseases/diagnosis , Spain/epidemiology , Syphilis/epidemiologyABSTRACT
No disponible
Subject(s)
Humans , Adult , Calcinosis/complications , Dermatomyositis/complications , Ectodermal Dysplasia/complications , Diagnostic ImagingABSTRACT
Se describe el caso de un adenoma hepático de gran tamaño que debutó con hemorragia, dolor abdominal y fiebre de varios días de evolución. Se enumeran algunas entidades que puedan estar asociadas al adenoma hepático. Se enfatiza en las pruebas de imagen como métodos para un diagnóstico correcto, que debe confirmarse con el estudio anatomopatológico (AU)
We describe the case of a teenager with a large hepatic adenoma who presented with bleeding, abdominal pain and fever for some days. Some entities may be associated with hepatic adenoma. Emphasis is placed on imaging test as methods for a correct diagnosis, which must be confirmed by pathological study (AU)
Subject(s)
Humans , Adenoma, Liver Cell/pathology , Liver Neoplasms/pathology , Gastrointestinal Hemorrhage/etiology , Fever/etiology , Diagnostic ImagingABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Hernia, Diaphragmatic/complications , Hernia, Diaphragmatic , Diagnosis, Differential , Radiography, Thoracic/trends , Radiography, ThoracicABSTRACT
No disponible
Subject(s)
Aged , Female , Humans , Streptococcal Infections , Streptococcus bovis , Discitis , Magnetic Resonance ImagingABSTRACT
OBJECTIVES: This phase I study was designed to evaluate the safety, tolerability and pharmacokinetics of intra-arterial basic fibroblast growth factor (bFGF) in patients with atherosclerotic peripheral arterial disease (PVD) and intermittent claudication. We also assessed the effects of basic fibroblast growth factor (bFGF) on calf blood flow as a measure of biologic activity. BACKGROUND: Preclinical studies have shown that bFGF, an angiogenic peptide, promotes collateral development in animal models of myocardial and hind limb ischemia. The safety and efficacy of bFGF in patients is unknown, and early clinical trials are underway in coronary and peripheral arterial disease. METHODS: A double-blind, placebo-controlled, dose-escalation trial was conducted in patients with claudication demonstrating ankle/brachial index <0.8. Patients were randomly assigned to placebo (n = 6), 10 microg/kg of bFGF (n = 4), 30 microg/kg of bFGF once (n = 5) and 30 microg/kg of bFGF on two consecutive days (n = 4). Study drug was infused into the femoral artery of the ischemic leg. Detailed safety information including retinal photography for neovascularization were obtained through one year. Calf blood flow was measured with strain gauge plethysmography in the two higher dose treatment groups and in four placebo patients at baseline, one month and three to seven months after treatment. RESULTS: Intra-arterial bFGF was safe and well-tolerated. The half-life was 46 +/- 21 min. Calf blood flow increased at one month by 66 +/- 26% (mean +/- SEM) and at six months by 153 +/- 51% in bFGF-treated patients (n = 9, p = 0.002). Flow did not change significantly in the placebo group. CONCLUSIONS: In this initial randomized, double-blind, placebo-controlled trial in patients with atherosclerotic PVD and claudication, bFGF was well-tolerated. The data suggest a salutary biologic effect, and initiation of phase 2 trials is warranted.
Subject(s)
Fibroblast Growth Factor 2/administration & dosage , Intermittent Claudication/drug therapy , Aged , Ankle/blood supply , Blood Flow Velocity/drug effects , Brachial Artery/drug effects , Brachial Artery/physiopathology , Double-Blind Method , Female , Fibroblast Growth Factor 2/pharmacokinetics , Half-Life , Humans , Injections, Intra-Arterial , Intermittent Claudication/blood , Intermittent Claudication/physiopathology , Male , Plethysmography , SafetySubject(s)
Discitis/microbiology , Streptococcal Infections , Streptococcus bovis , Aged , Female , Humans , Magnetic Resonance ImagingABSTRACT
The low current prevalence of leprosy in Spain together with the diversity of its clinical expression make the detection of this disease difficult. Three native and three imported cases are here reported. Different specialists mistook this disease for other entities: familial polyneuropathy, autoimmune disease, tuberculosis, cutaneous mycosis, and cutaneous sarcoidosis. Lepra is a very polymorphic disease and its diagnosis is based on finding cutaneous hypoesthesic lesions, neural thickening and presence of acid-fast bacilli (in cutaneous specimens or nasal exudates).
Subject(s)
Leprosy/diagnosis , Adult , Aged , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Leprostatic Agents/therapeutic use , Leprosy/therapy , Leprosy, Borderline/diagnosis , Leprosy, Borderline/therapy , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/therapy , Leprosy, Tuberculoid/diagnosis , Leprosy, Tuberculoid/therapy , Male , Middle Aged , Time FactorsSubject(s)
Diagnosis, Differential , Time Factors , Leprostatic Agents/therapeutic use , Leprosy, Borderline/diagnosis , Leprosy, Borderline/therapy , Leprosy, Tuberculoid/diagnosis , Leprosy, Tuberculoid/therapy , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/therapy , Leprosy/diagnosis , Leprosy/therapy , Follow-Up StudiesABSTRACT
Thoracic aspiration biopsy (TAB) constitutes a useful technique in establishing a diagnosis in diseases of the lungs and mediastinum. Results obtained from 1046 fluoroscopically-guided TABs are presented with review of the most important aspects of the technique. Diagnostic accuracy in malignancy detection was 93.8% in lung lesions (n = 984) and 74.5% in mediastinal lesions (n = 62). Sensitivity was higher in peripheral than in central lesions (96% vs. 87%, respectively). Specificity was 100% in both groups. Sensitivity in lesions smaller than 2 cm was 70% and 94% in larger lesions. Aspiration biopsies performed with Chiba and Franseen needles showed a similar sensitivity (95%) higher than with other types of needles. A pneumothorax developed in 138 patients (13.2%). Only eight of these required the use of an endothoracic tube (0.8% of all biopsies).
