Role of Calcitonin and Strontium Ranelate in Osteoporosis.

Background: Both Strontium Ranelate (SR) and Calcitonin (CT) can be used to treat osteoporosis. Calcitonin was actually one of the very initial medicines used to treat osteoporosis, especially in postmenopausal cases. However, the fracture prevention effect of Calcitonin is only proven to be in vertebrae and that too with nasal route only. When comparing Calcitonin with other conventional medications in treating osteoporosis, Calcitonin has got no additional advantages. Strontium Ranelate has got double effect, i.e., less bone resorption and more bone formation. Therefore, it can lead to an increase in bone mass significantly. Strontium Ranelate has been proven to decrease the risk of non-vertebral fractures as well as vertebral fractures. Conclusion: Both Calcitonin and Strontium Ranelate are used only as a second-line therapy for the treatment of osteoporosis and not as first-line therapy, mainly because of their safety concern and also because they do not provide any advantages compared to other therapy for the treatment of osteoporosis.

Comparison of Local and Intravenous Zoledronic Acid on Histopathology and Recurrence Rate after Extended Curettage in Giant Cell Tumors of Proximal Tibia: A Prospective Study.

Introduction: The bone pathology-giant cell tumor (GCT) is a locally aggressive and recurrent lesion. A bisphosphonate-zoledronic acid (ZA) has been known to lower the recurrence and resorption in similar bone lesions. Hence, we evaluated the effectivity of the ZA for the GCT of the proximal tibia. Materials and Methods: We piloted a prospective clinical observational study. We included 100 subjects with GCT, who were divided into two equal groups of case (given ZA) and control (no ZA). The histopathological features and the recurrence rates along with other findings were compared with P < 0.05 deliberated as significant. Results: We observed that for in the case group, calcification and fibrosis that were beneficial were observed. Reduced giant cells and lower recurrence rate are seen in the case group. No significant variation in the functional outcome was seen between the groups. Conclusions: ZA was shown to have beneficial effect on the outcome for the treatment of the GCT.

Clinicoradiological Comparison of Outcomes of LRS Fixator and Ilizarov in Infected Nonunion of Tibia Based on Bone Gap Quantification: An Original Research.

Introduction: The surgery of the fracture of the long bones is inherent to certain complications, one being nonunion. As various modalities are proposed, we aim in our study to compare the clinical and radiographic outcomes after the treatment with the Limb Reconstruction System (LRS) fixator and Ilizarov for the infected tibia with nonunion considering the bone gap quantifications. Materials and Methods: We conducted an observational prospective study among 40 subjects with tibial nonunion. They were grouped equally to be treated by the LRS fixator and Ilizarov. Clinical and radiographic outcomes were compared using the "Chi-squared and independent Student's t-test," deliberating P < 0.05 as significant. Results: We observed no significant difference for both the groups in the clinical union and functional and radiographic outcome for the various gaps of the nonunion. There was no significant difference for the groups when the time of healing was compared. Conclusion: Comparable results are seen for both the treatment modalities. However, IL fixator performed better clinically, while the LRS was easily accepted by the patients.

Knowledge, Attitude, and Practice Related to OMICRON among Health-Care Personnel: An Original Research.

Introduction: At the time when the world was unprepared for the corona pandemic, the health-care workers faced the challenge with great effort. Recently, the OMICRON has been burdening the medical fraternity. Hence, in our study, we aimed to evaluate the "knowledge, attitude, and practices" related to OMICRON among the medical health-care staff. Materials and Methods: We piloted an online cross-sectional questionnaire study using Google Forms among 1000 medical staff working at various levels of public and private sections. The questions were formulated to test for the practices, attitude, and knowledge of the new variant OMICRON. The data collected were compared using the Chi-square test, deliberating P < 0.05 as significant. Results: We observed that majority were male participants, with significant number at the ages of 20-40 years. There was lower knowledge, although good practice and positive attitude were noted among the medical health staff. Conclusion: The medical health-care personnel possessed less knowledge regarding the new variant OMICRON, although positive practices and attitudes were noted. Hence, the governments should take necessary steps to implement the training about the new variant.