ABSTRACT
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Subject(s)
Humans , Male , Adult , Molecular Typing/methods , Pituitary Hormones, Anterior/therapeutic use , Neuroendocrine Tumors/drug therapy , Pituitary Hormones, Anterior/genetics , Pituitary Hormones, Anterior/metabolism , Pituitary Neoplasms/drug therapy , Immunohistochemistry , Neuroendocrine Tumors/classificationSubject(s)
Neuroendocrine Tumors/genetics , Pituitary Hormones, Anterior/genetics , Pituitary Neoplasms/genetics , Adult , Humans , Male , Neuroendocrine Tumors/diagnosis , Neuroendocrine Tumors/therapy , Pituitary Hormones, Anterior/classification , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/therapyABSTRACT
Tóxicos como la cocaína y fármacos como los antipsicóticos atípicos, entre los que se encuentra la olanzapina, se relacionan en ocasiones con la aparición de hiperglucemia. Mientras que la cocaína eleva la glucemia por la liberación de catecolaminas, los antipsicóticos atípicos actúan principalmente aumentando el apetito y el peso y desarrollando síndrome metabólico. Este último grupo de fármacos también tiene una actuación independiente de la ganancia ponderal o la adiposidad por la inhibición de la célula beta pancreática y la disminución de la acción periférica de la insulina. El caso expuesto describe la aparición de una hiperglucemia aguda grave, tras intento suicida con olanzapina y cocaína, en una mujer de 29 años que presentó, tras retirada del fármaco y ausencia de consumo de cocaína, normalización inmediata de la glucemia, sin diagnóstico posterior de diabetes mellitus (AU)
Drugs such as cocaine and atypical antipsychotic agents, such as olanzapine, are sometimes related to hyperglycemia. Where as cocaine raises plasma glucose through catecholamine release, atypical antipsychotic agents mainly increase appetite and induce weight gain and the development of metabolic syndrome. Moreover, the latter group of drugs also act independently from weight gain oradiposity, due to inhibition of beta pancreatic cells and reduction of peripheral insulin action. We present the case of a 29-year-old non-diabetic woman with severe acute hyperglycemia in the context of a suicide attempt through intake of olanzapine and cocaine. After discontinuation of olanzapine and cocaine consumption, glycemia was immediately normalized without subsequent diagnosis of diabetes (AU)
Subject(s)
Humans , Female , Adult , Hyperglycemia/chemically induced , Cocaine/adverse effects , Antipsychotic Agents/adverse effects , Suicide, Attempted , Respiratory Insufficiency/chemically inducedABSTRACT
Drugs such as cocaine and atypical antipsychotic agents, such as olanzapine, are sometimes related to hyperglycemia. Whereas cocaine raises plasma glucose through catecholamine release, atypical antipsychotic agents mainly increase appetite and induce weight gain and the development of metabolic syndrome. Moreover, the latter group of drugs also act independently from weight gain or adiposity, due to inhibition of beta pancreatic cells and reduction of peripheral insulin action. We present the case of a 29-year-old non-diabetic woman with severe acute hyperglycemia in the context of a suicide attempt through intake of olanzapine and cocaine. After discontinuation of olanzapine and cocaine consumption, glycemia was immediately normalized without subsequent diagnosis of diabetes.
