ABSTRACT
Atypical fibroxanthoma (AFX) is an uncommon dermal-based neoplasm arising on the sun-damaged skin of elderly people. Clear cell AFX is a rare variant with only 12 cases reported until the present date, all of them as case reports, except for 1 small series of 3 cases. The authors report 6 new cases and review the literature with special emphasis on the differential diagnosis. The clear cell variant represents 5% of AFX from their files. Histopathologically, it consists of sheets of epithelioid, pleomorphic cells, intermixed with a varying number of giant multinucleated and spindle cells, the latter arranged in a fascicular pattern. All cell types predominantly exhibit a clear, microvacuolated cytoplasm with well-demarcated cell borders. The clinical and immunohistochemical features of this variant are similar to those of the classic type. Clear cell AFX must be differentiated from other cutaneous clear cell neoplasms, some of them with an aggressive clinical behavior, including clear cell melanoma, primary cutaneous and metastatic clear cell carcinomas, clear cell sarcoma, pleomorphic liposarcoma, tumor of perivascular epithelioid cells, and distinctive dermal clear cell mesenchymal neoplasm. The clinical presentation and immunohistochemical profile play a key role in the differential diagnosis.
Subject(s)
Head and Neck Neoplasms/pathology , Scalp/pathology , Skin Neoplasms/pathology , Aged , Aged, 80 and over , Biomarkers, Tumor/analysis , Biopsy , Diagnosis, Differential , Female , Head and Neck Neoplasms/chemistry , Head and Neck Neoplasms/classification , Head and Neck Neoplasms/surgery , Humans , Immunohistochemistry , Male , Predictive Value of Tests , Prognosis , Scalp/chemistry , Scalp/surgery , Skin Neoplasms/chemistry , Skin Neoplasms/classification , Skin Neoplasms/surgery , SpainABSTRACT
The association between leukocytoclastic vasculitis and solid tumors like renal carcinoma has been infrequently described. We present the case of a 76-year-old woman who began with skin lesions on the legs that were clinically and histologically diagnosed as leukocytoclastic vasculitis. During analysis of the symptoms, she was diagnosed with renal carcinoma. After the tumor was excised, the vasculitis lesions disappeared, with no recurrence during the follow-up period.
Subject(s)
Carcinoma, Renal Cell/complications , Kidney Neoplasms/complications , Vasculitis, Leukocytoclastic, Cutaneous/etiology , Aged , Carcinoma, Renal Cell/diagnostic imaging , Female , Humans , Kidney Neoplasms/diagnostic imaging , Kidney Neoplasms/surgery , Nephrectomy , Radiography , Remission Induction , Vasculitis, Leukocytoclastic, Cutaneous/surgeryABSTRACT
La asociación entre vasculitis leucocitoclástica y tumores sólidos como el carcinoma renal se ha descrito con poca frecuencia. Presentamos el caso de una mujer de 76 años que empezó con lesiones cutáneas en piernas clínica e histológicamente diagnosticadas de vasculitis leucocitoclástica y a la que, en el transcurso del estudio del cuadro, se le diagnosticó un carcinoma renal. Tras la extirpación del tumor renal, las lesiones de vasculitis desaparecieron sin recidiva en el seguimiento
The association between leukocytoclastic vasculitis and solid tumors like renal carcinoma has been infrequently described. We present the case of a 76-year-old woman who began with skin lesions on the legs that were clinically and histologically diagnosed as leukocytoclastic vasculitis. During analysis of the symptoms, she was diagnosed with renal carcinoma. After the tumor was excised, the vasculitis lesions disappeared, with no recurrence during the follow-up period
Subject(s)
Female , Middle Aged , Humans , Carcinoma, Renal Cell/complications , Carcinoma, Renal Cell/diagnosis , Vasculitis, Leukocytoclastic, Cutaneous/complications , Vasculitis, Leukocytoclastic, Cutaneous/pathology , Biopsy/methods , Prednisone/administration & dosage , Prednisone/therapeutic use , Skin Diseases, Vesiculobullous/complications , Skin Diseases, Vesiculobullous/diagnosis , Radiography, Thoracic/methodsSubject(s)
Hand Dermatoses/diagnosis , Mycobacterium Infections, Nontuberculous/diagnosis , Mycobacterium marinum/isolation & purification , Adult , Animals , Animals, Domestic , Disease Reservoirs/microbiology , Erythema/etiology , Fishes/microbiology , Hand Dermatoses/microbiology , Humans , Male , Mycobacterium Infections, Nontuberculous/microbiology , Mycobacterium Infections, Nontuberculous/transmission , Mycobacterium chelonae/isolation & purification , Tuberculoma/etiology , Water MicrobiologyABSTRACT
No disponible
Subject(s)
Male , Adult , Humans , Hand Dermatoses/complications , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Biopsy/methods , Mycobacterium marinum/isolation & purification , Mycobacterium marinum/pathogenicity , Skin Diseases, Parasitic/complications , Skin Diseases, Parasitic/diagnosis , Mycobacterium Infections/complications , Mycobacterium Infections/diagnosis , Bacterial Infections/complications , Bacterial Infections/diagnosis , Skin Diseases, Parasitic/pathology , Skin Diseases, Parasitic/physiopathology , Mycobacterium Infections/pathologyABSTRACT
La epidermis situada sobre un dermatofibroma puede mostrar cambios que varían desde la hiperplasia simple hasta la proliferación de células basaloides, que puede llegar a ser morfológicamente indistinguible del carcinoma basocelular. La coexistencia de un verdadero carcinoma basocelular sobre dermatofibroma es poco frecuente. Habitualmente, estas proliferaciones basaloides se han considerado el resultado del efecto inductivo de la proliferación fibrohistiocitaria del dermatofibroma sobre las células epiteliales del folículo piloso, por lo que se trataría de un fenómeno reactivo y no verdaderamente neoplásico. Describimos un caso de dermatofibroma que presenta en la epidermis suprayacente una proliferación de aspecto basaloide idéntica a un carcinoma basocelular
The epidermis over a dermatofibroma may show changes that range from simple hyperplasia to the proliferation of basaloid cells, which can become morphologically indistinguishable from basal cell carcinoma. The existence of a true basal cell carcinoma overlying a dermatofibroma is infrequent. These basaloid proliferations have usually been considered to be the result of the inductive effect of the fibrohistiocytic proliferation of the dermatofibroma on the epithelial cells of the hair follicle; therefore, it would be a reactive phenomenon and not truly neoplastic. We describe a case of dermatofibroma that presented with a basaloid proliferation identical in appearance to a basal cell carcinoma on the overlying epidermis
Subject(s)
Female , Middle Aged , Humans , Carcinoma, Basal Cell/complications , Carcinoma, Basal Cell/diagnosis , Carcinoma, Basal Cell/therapy , Immunohistochemistry/methods , Dermatofibrosarcoma/complications , Dermatofibrosarcoma/diagnosis , Histiocytoma, Benign Fibrous/diagnosis , Histiocytoma, Benign Fibrous/therapy , Endometrial Hyperplasia/complications , Lymphoma, Follicular/complications , Adenocarcinoma, Follicular/complications , Neurofibroma/complications , Neurofibroma/diagnosis , Keratosis, Seborrheic/complications , Keratosis, Seborrheic/diagnosisABSTRACT
The epidermis over a dermatofibroma may show changes that range from simple hyperplasia to the proliferation of basaloid cells, which can become morphologically indistinguishable from basal cell carcinoma. The existence of a true basal cell carcinoma overlying a dermatofibroma is infrequent. These basaloid proliferations have usually been considered to be the result of the inductive effect of the fibrohistiocytic proliferation of the dermatofibroma on the epithelial cells of the hair follicle; therefore, it would be a reactive phenomenon and not truly neoplastic. We describe a case of dermatofibroma that presented with a basaloid proliferation identical in appearance to a basal cell carcinoma on the overlying epidermis.
Subject(s)
Carcinoma, Basal Cell/pathology , Histiocytoma, Benign Fibrous/pathology , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/pathology , Female , Humans , Middle AgedABSTRACT
Se describe un método simple y barato para seleccionar cepas productoras de material rico en carbohidratos, esta característica se atribuye a ciertas cepas de estafilococos coagulasa negativos y favorece su crecimiento sobre superficies lisas. Los enfermos que portaban estafilococos adherentes tuvieron más infecciones clínicas (21/25 casos) aquellos que portaban estafilococos "no adherentes"-(10/35 casos) p 0.001. La patogenicidad de los primeros podría esta asociada a esa caracteristica biológica
