[Correlation between the six-minute walk test and maximal exercise test in patients with type ii diabetes mellitus]. / Correlación entre prueba de marcha de 6 minutos y prueba de esfuerzo máxima en pacientes con diabetes mellitus de tipo ii.

INTRODUCTION: The 6-minute walk test is an exercise test that has been used in diabetic patients to assess the effectiveness of exercise programmes and has been correlated with clinical parameters; however, the correlation with the maximum workload registered during stress testing has not been determined in diabetic patients. OBJECTIVE: To establish the correlation between the 6-minute walk test and the maximum workload registered during a stress test in patients with type ii diabetes mellitus and its association with glycemic control. MATERIALS AND METHODS: We included 42 patients with type ii diabetes mellitus and mean age of 61.1 years, who underwent physical examination, a 6-minute walk test, a treadmill stress test and laboratory studies. RESULTS: The 6-minute walk test had high reproducibility in diabetic patients and showed a moderate-low correlation with maximum workload on the treadmill (r=49, p=0.001). A significant association was found between the 6-minute walk test and glycosylated haemoglobin A1C values (RP 1.57, χ2 <0.05). CONCLUSION: The 6-minute walk test is a highly reproducible test and has a significant correlation with maximum physical workload in the diabetic patients tested. Therefore, it can be used as a test for assessing functional capacity in this population.

[Efficacy of Ozone Infiltrations in the Treatment of Knee Osteoarthritis Vs Other Interventional Treatments: A Systematic Review of Clinical Trials]. / Eficacia de las infiltraciones con ozono en el tratamiento de la osteoartritis de rodilla vs. otros tratamientos intervencionistas: revisión sistemática de ensayos clínicos.

INTRODUCTION: Intra-articular ozone infiltrations have been used as a therapeutic intervention in osteoarthritis of the knee with reports of favourable effects. However, this therapeutic procedure is still controversial due to the lack of scientific evidence to justify its use. OBJECTIVE: To evaluate the safety and efficacy of intra-articular ozone infiltrations in patients with knee osteoarthritis. MATERIAL AND METHODS: A systematic search was performed in electronic databases such as Pubmed, Dialnet, Scielo, Medigraphic and other electronic sources from January 1990 to January 2018. We included controlled clinical trials that used intra-articular ozone infiltrations as a therapeutic intervention in patients with knee osteoarthritis. The variables analysed were the study design, risk of bias, clinical configuration, characteristics of the participants, characteristics of the interventions, results, length of follow-up and adverse events. RESULTS: Ten studies with a total of 400 patients treated with ozone vs 381 controls were included in the systematic review. Most studies had a high risk of bias. Intra-articular ozone infiltrations were more effective than placebo and were as effective as other interventional treatments in short-term follow-up. No adverse effects or serious adverse reactions were reported in the treated patients. CONCLUSION: Intra-articular ozone infiltration appears to be an effective therapeutic intervention in the short term. However studies with better methodological quality are needed to confirm its efficacy and to analyze long-term safety.