ABSTRACT
Objective: This study was aimed at comparing cardiorespiratory fitness (CF), measured as VO2 max, amongst school children exposed to varying levels of particulate matter (PM10), and air pollution in Bogotá, Colombia. Methods: This was a cross-sectional study; it involved 1,045 children aged 7-12 attending four public schools served by different public transit routes and systems. Three schools were classified as being highly polluted (HP) and one slightly polluted (SP). The children and their parents were surveyed to collect data regarding their socio-demographic characteristics, physical activity habits and respiratory disease background. Objective measurements of weight and height were used to calculate the body mass index. VO2max was estimated using the 20-meter shuttle-run test, previously validated for Bogotá. Spirometry was performed on 435 children. Results: After adjustment for covariates, no difference was found in VO2max between children attending SP or HP schools (girls SP 45.8 ml/kg/min vs HP 44.6 ml/kg/min, p=0.11; boys SP 47.2 ml/kg/min cf HP 48.2 ml/kg/min, p=0.41). Conclusions: VO2max levels did not differ amongst children attending schools exposed to high compared to low levels of air pollution and PM. A longitudinal study assessing children’s VO2max levels in relation to exposure to highly-polluted areas is warranted.
Objetivo: Comparar el acondicionamiento cardiorespiratorio medido como VO2 máximo en niños escolarizados expuestos a diferentes niveles de PM10 en Bogotá. Métodos: Estudio de corte transversal. Se incluyeron 1045 niños de 7-12 años de 4 colegios públicos con diferentes corredores viales y sistemas de transporte público. Tres colegios tenían alta contaminación (AC) y uno baja contaminación (BC). Se aplicó una encuesta a niños y padres sobre características sociodemográficas, actividad física, antecedentes de enfermedades respiratorias y salud. Se midió objetivamente peso y talla para calcular el índice masa corporal. El VO2 máximo se estimó con la prueba de Leger validada para Bogotá. Se realizaron espirometrias en 435 niños. Resultados: Después de ajustar por covariables, no se encontraron diferencias significativas en el VO2 máximo de los niños en colegios con BC ò AC. (Niñas BC: 45,8ml/kg/min vs. AC: 44,6ml/kg/min; p=0,11, niños BC: 47,2ml/kg/min vs. AC: 48,2ml/kg/min; p=0,41). Conclusión: No se encontraron diferencias en el VO2 máximo de los niños que asistían a los colegios de AC ó BC. Se recomienda un estudio longitudinal que evalúe los niveles de VO2 máximo en los niños expuestos a áreas altamente contaminadas.
Subject(s)
Child , Female , Humans , Male , Air Pollution , Heart/physiology , Particulate Matter , Physical Fitness , Play and Playthings , Respiratory Physiological Phenomena , Colombia , Cross-Sectional Studies , Spirometry , Urban HealthABSTRACT
BACKGROUND: While it is suggested that the prevalence of asthma in developed countries may have stabilized, this is not clear in currently developing countries. Current available information for both adults and children simultaneously on the burden and impact of allergic conditions in Colombia and in many Latin American countries is limited. The objectives of this study were to estimate the prevalence for asthma, allergic rhinitis (AR), atopic eczema (AE), and atopy in six colombian cities; to quantify costs to the patient and her/his family; and to determine levels of Immunoglobulin E (IgE) in asthmatic and healthy subjects. METHODS: We conducted a cross-sectional, population-based study in six cities during the academic year 2009-2010. We used a school-based design for subjects between 5-17 years old. We carried out a community-based strategy for subjects between 1-4 years old and adults between 18-59 years old. Serum samples for total and antigen-specific (IgE) levels were collected using a population-based, nested, case-control design. RESULTS: We obtained information on 5978 subjects. The largest sample of subjects was collected in Bogotá (2392). The current prevalence of asthma symptoms was 12% (95% CI, 10.5-13.7), with 43% (95% CI, 36.3-49.2) reporting having required an emergency department visit or hospitalization in the past 12 months. Physician diagnosed asthma was 7% (95% CI, 6.1-8.0). The current prevalence of AR symptoms was 32% (95% CI, 29.5-33.9), and of AE symptoms was 14% (95% CI, 12.5-15.3). We collected blood samples from 855 subjects; 60.2% of asthmatics and 40.6% of controls could be classified as atopic. CONCLUSIONS: In Colombia, symptom prevalence for asthma, AR and AE, as well as levels of atopy, are substantial. Specifically for asthma, symptom severity and absence from work or study due to symptoms are important. These primary care sensitive conditions remain an unmet public health burden in developing countries such as Colombia.
Subject(s)
Asthma/epidemiology , Dermatitis, Atopic/epidemiology , Hypersensitivity, Immediate/epidemiology , Immunoglobulin E/blood , Rhinitis, Allergic, Perennial/epidemiology , Adult , Case-Control Studies , Child , Child, Preschool , Colombia/epidemiology , Cost of Illness , Cross-Sectional Studies , Developing Countries , Female , Humans , Hypersensitivity, Immediate/blood , Infant , Male , Middle Aged , Prevalence , Statistics, NonparametricABSTRACT
OBJECTIVE: Allergic rhinitis is one of the most frequent chronic diseases among children. The objective of the study was to assess the prevalence of rhinoconjunctivitis and determine clinical, social and environmental associated factors, among school children aged 6-7 years and adolescents aged 13-14 years in Bogotá, Colombia. METHODS: We used ISAAC (International Study of Asthma and Allergies in Childhood) phase III study methodology and questionnaire for design and data collection, and we did a secondary analysis of these data. The sample consisted of 3830 registers from adolescents between 13 and 14 years old and 3256 registers from children between 6 and 7 years. RESULTS: The prevalence of rhinoconjunctivitis symptoms in the last year was 17.2% (95% CI, 15.9-18.5) in children vs. 24.9% (95% CI, 23.6-26.3) in adolescents. In both groups there was a female predominance in children (17.8% vs. 16.5%), and in the teenagers group (28.0% vs. 21.4%), though the differences were not statistically significant. The factors associated with rhinoconjunctivitis in the group of 6-7 years where: asthma [OR 3.9; (95% CI, 2.8-5.4)], atopic dermatitis [OR 2.3; (95% CI, 1.7-3.1)], use of acetaminophen in the last year [OR 2.6; (95% CI, 1.4-4.9)], use of antibiotics in the first year of live [OR 1.7; (95% CI, 1.3-2.3)], higher maternal education [OR 1.5; (95% CI, 1.0-2.3)] and cesarean delivery [OR 1.6; (95% CI, 1.2-2.1)]. Among the 13-14 year age-group, factors associated with rhinoconjunctivitis included: asthma [OR 2.6; (95% CI, 2.0-3.4)], atopic dermatitis [OR 1.8; (95% CI, 1.4-2.3)], use of acetaminophen in the last year [OR 1.8; (95% CI, 1.4-2.4)], consumption of fast-food three times or more per week [OR 1.5; (95% CI, 1.2-2.0), ever smoked [OR 1.4; (95% CI, 1.2-1.7)] and meat consumption was protective factor [OR 0.7; (95% CI, 0.5-0.9)]. CONCLUSION: In both studied groups, the estimated prevalence of rhinoconjunctivitis symptoms was relatively high. Future in-depth research is needed to assess the complex interactions between allergic rhinoconjunctivitis symptoms and social and environmental factors.
Subject(s)
Conjunctivitis, Allergic/complications , Conjunctivitis, Allergic/epidemiology , Rhinitis/complications , Rhinitis/epidemiology , Adolescent , Age Factors , Asthma/complications , Asthma/diagnosis , Child , Cohort Studies , Colombia , Conjunctivitis, Allergic/diagnosis , Cross-Sectional Studies , Dermatitis, Atopic/complications , Dermatitis, Atopic/diagnosis , Female , Humans , Male , Prevalence , Rhinitis/diagnosis , Risk FactorsABSTRACT
OBJECTIVE: This study was aimed at comparing cardiorespiratory fitness (CF), measured as VO2 max, amongst school children exposed to varying levels of particulate matter (PM10), and air pollution in Bogotá, Colombia. METHODS: This was a cross-sectional study; it involved 1,045 children aged 7-12 attending four public schools served by different public transit routes and systems. Three schools were classified as being highly polluted (HP) and one slightly polluted (SP). The children and their parents were surveyed to collect data regarding their socio-demographic characteristics, physical activity habits and respiratory disease background. Objective measurements of weight and height were used to calculate the body mass index. VO2max was estimated using the 20-meter shuttle-run test, previously validated for Bogotá. Spirometry was performed on 435 children. RESULTS: After adjustment for covariates, no difference was found in VO2max between children attending SP or HP schools (girls SP 45.8 ml/kg/min vs HP 44.6 ml/kg/min, p=0.11; boys SP 47.2 ml/kg/min cf HP 48.2 ml/kg/min, p=0.41). CONCLUSIONS: VO2max levels did not differ amongst children attending schools exposed to high compared to low levels of air pollution and PM. A longitudinal study assessing children's VO2max levels in relation to exposure to highly-polluted areas is warranted.
Subject(s)
Air Pollution , Heart/physiology , Particulate Matter , Physical Fitness , Play and Playthings , Respiratory Physiological Phenomena , Child , Colombia , Cross-Sectional Studies , Female , Humans , Male , Spirometry , Urban HealthABSTRACT
OBJECTIVES: To evaluate the effect of montelukast, 5 mg, or inhaled salmeterol, 50 microg, added to inhaled fluticasone in reducing the maximum percentage decrease in forced expiratory volume in 1 second (FEV1) after a standardized exercise challenge and response to rescue bronchodilation with albuterol in children aged 6 to 14 years with persistent asthma and exercise-induced bronchoconstriction (EIB). METHODS: Randomized, double-blind, double-dummy, multicenter, 2-period, 4-week, crossover study conducted between December 22, 2005 and November 14, 2008 at 30 centers in Europe, Asia, Mexico, and South America. Patients with asthma receiving inhaled corticosteroids demonstrated an FEV1 of 70% or higher of the predicted value and EIB (defined as a decrease in FEV1 > or = 15% compared with preexercise baseline FEV1 on 2 occasions before randomization). Standardized exercise challenges were performed at baseline (prerandomization) and at the end of each active treatment period. RESULTS: Of 154 patients randomized, 145 completed the study. Montelukast, compared with salmeterol, significantly reduced the mean maximum percentage decrease in FEV1 (10.6% vs 13.8%; P = .009), mean area under the curve for the first 20 minutes after exercise (116.0% x min vs 168.8% x min; P = .006), and median time to recovery (6.0 vs 11.1 minutes; P = .04). Response to albuterol rescue after exercise challenge was significantly greater (P < .001) with montelukast. Montelukast and salmeterol were generally well tolerated. CONCLUSIONS: Attenuation and response of EIB to albuterol rescue after exercise challenge were significantly better with montelukast than with salmeterol after 4 weeks of treatment.
Subject(s)
Acetates/administration & dosage , Albuterol/analogs & derivatives , Androstadienes/administration & dosage , Anti-Asthmatic Agents/administration & dosage , Asthma/drug therapy , Bronchoconstriction/drug effects , Exercise , Quinolines/administration & dosage , Acetates/adverse effects , Adolescent , Albuterol/administration & dosage , Albuterol/adverse effects , Androstadienes/adverse effects , Asthma/physiopathology , Child , Cross-Sectional Studies , Cyclopropanes , Double-Blind Method , Female , Fluticasone , Forced Expiratory Volume , Humans , Male , Quinolines/adverse effects , Salmeterol Xinafoate , SulfidesABSTRACT
Introducción: Las infecciones respiratorias agudas (IRA), principalmente la neumonía y en segundo lugar la bronquiolitis, son la causa infecciosa más frecuente de muerte en niños menores de cinco años de edad. Objetivo: Determinar el papel de potenciales factores de riesgo como predictores de mortalidad por infección respiratoria aguda. Método: Estudio observacional analítico de casos y controles con 258 pacientes pediátricos menores de cinco años con enfermedad respiratoria aguda atendidos en cuatro hospitales de la zona suroriental de Bogotá. Resultados: Los hallazgos de acidosis metabólica, acidemia al momento del ingreso a la unidad de cuidado intensivo (UCI) y el antecedente de ingreso a la UCI en los meses de marzo, abril y mayo, respecto al ingreso en los demás meses del año, fueron predictores de la mortalidad. Entre tanto, la presencia de aleteo nasal y la administración de antibióticos en la segunda consulta, mostraron reducir el riesgo de mortalidad. Palabras clave: neumonía, mortalidad, infección, enfermedad pulmonar intersticial.
Introduction: In acute respiratory infections (ARI), pneumonia in the first place and bronchiolitis in the second place are the most common infectious cause of death in children under five years old. Objective: To establish the role of potential risk factors as predictors of mortality from acute respiratory infection. Method: An observational/analytic case-control study was conducted with 258 pediatric patients younger than five years old with acute respiratory disease (ARD) treated at four south-eastern hospitals in Bogotá. Results: Findings of metabolic acidosis and acidemia at ICU admission, as well as patients clinical history at ICU admission were taken as mortality predictors in the months of March, April and May, with regard to their admission in other months, and the presence of nasal flaring and the administration of antibiotics at the second consultation decreased mortality risk. Key words: Pneumonia, mortality, infection, interstitial lung disease.
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Respiratory Tract Diseases , Respiratory Tract Infections , Minors , Pneumonia , Bronchiolitis , Case-Control Studies , Risk Factors , Cause of Death , Lung Diseases, Interstitial , DeathABSTRACT
This cross-sectional study of children aged 6-7 years and adolescents aged 13-14 years in Bogotá, Colombia, assessed the prevalence of asthma symptoms and their associations with dietary, health, and behavioral habits. This study is part of the International Study of Asthma and Allergies in Childhood (ISAAC)-phase III. Asthma prevalence among the children was assessed using a parental self-administered written questionnaire (WQ), and among adolescents using a WQ together with a video questionnaire (VQ). Associations were estimated with bivariate and multivariate analysis. The study found that the 6-7 year age-group were more likely to report current asthma symptoms than the 13-14 year age-group (10.4% [WQ] vs. 8.6% [WQ] and 8.0% [VQ], respectively). Factors associated with current asthma symptoms among the 6-7 year age-group included higher maternal education (OR = 1.7, [95% CI 1.2-2.6], p = 0.007), a cat in the home during the last year (OR = 1.5, [95% CI 1.0-2.3], p = 0.036), watching TV 1-2 hours/day (OR = 2.1, [95% CI 1.2-3.9], p = 0.013), and medication with acetaminophen in the first and most recent year of life (OR = 1.8, [95% CI 1.3-2.4], p < 0.001; OR = 2.2, [95% CI 1.7-2.8], p < 0.001, respectively) or antibiotics in the first year of life (OR = 1.9, [95% CI 1.4-2.5], p < 0.001). Among the 13-14 year age-group, factors associated with current asthma symptoms included medication with acetaminophen during the last year (OR = 1.8, [95% CI 1.4-2.3], p < 0.001); cereal, milk, and fruit consumption 3 or more times weekly (OR = 1.5, [95% CI 1.1-1.9], p = 0.010; OR = 0.8, [95% CI 0.6-1.0], p = 0.046; OR = 0.6, [95% CI 0.4-1.0], p = 0.031, respectively). Overall, compared with that in other Latin American centers, asthma prevalence in Bogotá is close the lower estimates. However, associations with dietary, health, and behavioral habits need further study to assess their complex relationship with asthma.
Subject(s)
Asthma/epidemiology , Asthma/physiopathology , Adolescent , Age Factors , Child , Child, Preschool , Colombia , Cross-Sectional Studies , Environmental Exposure/adverse effects , Female , Humans , Male , Risk Factors , Surveys and QuestionnairesABSTRACT
BACKGROUND: No detailed information is available on the burden and impact of allergic diseases simultaneously for adults and children in Colombia and most Latin American countries. OBJECTIVES: To investigate the prevalence of asthma, allergic rhinitis, and atopic dermatitis symptoms in 6 cities in Colombia; to measure patient expenses and school days and workdays lost; to describe disease severity; and to determine levels of total and specific IgE in asthmatic subjects. METHODS: A multistage stratified random sample selection of schools with subjects aged 5 to 18 years in each city was used. Guardian subjects selected were contacted, and home visits were arranged. Subjects aged 1 to 4 years and older than 19 years were also selected randomly by systematic sampling based on the addresses of the subjects aged 5 to 18 years. Subjects with asthma symptoms were invited to provide a blood sample. RESULTS: Information was obtained from 6,507 subjects. The prevalence of asthma, rhinitis, and atopic dermatitis symptoms in the past 12 months was 10.4% (95% confidence interval [CI], 9.7%-11.1%), 22.6% (95% CI, 21.6%-23.6%), and 3.9% (95% CI, 3.4%-4.4%), respectively. Thirty-eight percent of asthmatic subjects had visited the emergency department or have been hospitalized, and 50% reported lost school days and workdays. Seventy-six percent of sampled asthmatic patients were considered to be atopic. CONCLUSIONS: The burden of disease and societal consequences of allergic entities in urban settings in countries such as Colombia are of concern but are largely ignored, perhaps because of the misconception that these diseases are of public health importance only in industrialized nations.
Subject(s)
Asthma/epidemiology , Cost of Illness , Dermatitis/epidemiology , Rhinitis/epidemiology , Adolescent , Adult , Asthma/economics , Child , Child, Preschool , Colombia/epidemiology , Dermatitis/economics , Humans , Immunoglobulin E/blood , Infant , Middle Aged , Prevalence , Rhinitis/economics , Surveys and QuestionnairesABSTRACT
Cystic Fibrosis is a worldwide distributed hereditary disease. The incidence of the main (p.F508del) and other frequent mutations has been determined in a great number of countries and ethnic groups, but its incidence in most Latin American countries has remained unknown until recently. It is now beginning to be recognized as a frequent cause of infant mortality, and some countries report the incidence of their mutations. Colombia started several years ago a concerted program of molecular study of patients which were clinically diagnosed as probable cystic fibrosis. We screened the whole CFTR (ABCC7) coding sequence in 92 patients from 6 different geographic regions, using conventional PAGE analyses and DGGE followed by sequencing. Additionally, we established the frequency of the p.F508del mutation in 130 unrelated healthy controls. The results of this pilot study in Colombian patients from various ethnic admixture show six main mutations: p.F508del (41.8%), c.1811+1.6kbA>G (6.5%), p.G542X (3.8%), p.S549R (2.2%), p.W1282X (1.1%) and p.R1162X (1.1%). Thirteen other rare mutations, including three novel, were detected, accounting for a total of 63.6% known mutations. There is a great variability between the geographic regions, both in the frequency of the p.F508del mutation and non-p.F508del CF chromosomes. Our results point to a varied origin of the disease genes. These results also show that careful scrutiny of the mutations is needed in each part of Latin America in order to establish priority-screening protocols adapted to each country and region.
Subject(s)
Cystic Fibrosis Transmembrane Conductance Regulator/genetics , Cystic Fibrosis/genetics , Molecular Diagnostic Techniques/trends , Mutation , Adult , Colombia/epidemiology , Cystic Fibrosis/epidemiology , Gene Frequency/genetics , Genetic Carrier Screening , Genetic Testing/methods , Humans , Incidence , Male , Molecular Diagnostic Techniques/methods , Pilot ProjectsABSTRACT
La fibrosis quística (FQ), la enfermedad autosómica recesiva más frecuente en poblaciones caucásicas, tiene una incidencia promedio de 1/2.500 recién nacidos
