ABSTRACT
Adenocarcinoma frequency in Pu incorporation-related lung cancer patients among plutonium workers was found to be 74% versus 33% in control. Each histological pattern of lung cancer appeared to be related to several etiological factors but in varying degree. Incorporated Pu proved the strongest factor in adenocarcinoma development. Its odds ratio (OR) was 6.9, while that for smoking-4.3. However, smoking appeared to be the most significant factor in squamous cell carcinoma genesis (OR-6.8). Among other factors were chronic obstructive pathology of the lung (OR-3.9) and reduced body weight (OR-2.1). The OR for Pu incorporation was 3.9. Squamous cell carcinomas were traced to reduced body weight (OR-2.9), heavy smoking (smoking index more than 500) (OR-3.5). However, no significant relationship has been established between carcinogenesis and Pu incorporation.
Subject(s)
Lung Neoplasms/etiology , Lung Neoplasms/pathology , Neoplasms, Radiation-Induced/etiology , Neoplasms, Radiation-Induced/pathology , Occupational Diseases/etiology , Occupational Diseases/pathology , Occupational Exposure , Adenocarcinoma/etiology , Adenocarcinoma/pathology , Adult , Body Weight , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/pathology , Female , Humans , Male , Middle Aged , Odds Ratio , Plutonium/adverse effects , Risk Factors , Smoking/adverse effectsABSTRACT
Enrichment of rat daily diets by 1-2 (up to 5) mg selenium increased nonspecific resistance of animals to ionizing radiation. Incidence of mammary, pituitary, and thyroid tumors as well as of leukemia were lower as compared with control animal group given no selenium.
Subject(s)
Food, Fortified , Neoplasms, Radiation-Induced/diet therapy , Selenium/administration & dosage , Animals , Incidence , Male , Models, Biological , Neoplasms, Radiation-Induced/mortality , Random Allocation , Rats , Survival Rate , Time FactorsABSTRACT
Pulmonary cancer site was studied in 131 workers engaged into radioactive chemicals production and 178 examinees of control group. All examinees died in 1965-1989. Incorporation of plutonium-239 increased the number of lower lobe pulmonary cancers (upper-0.49; medium-0.06; lower-0.45) compared to 0.72; 0.03; 0.25 in control group. Ratio of cancer sites attributing to plutonium-239 was calculated for various levels of relative risk. Cancer site in the lower lobe appeared to show high probability attributing to plutonium-239 with relative risk over 1.39; in the case of upper lobe the relative risk was 3.67.
Subject(s)
Lung Neoplasms/pathology , Neoplasms, Radiation-Induced/pathology , Occupational Exposure , Plutonium/adverse effects , Radiochemistry , Humans , Lung Neoplasms/epidemiology , Lung Neoplasms/etiology , Male , Middle Aged , Neoplasms, Radiation-Induced/epidemiology , Neoplasms, Radiation-Induced/etiology , Risk Factors , Smoking/adverse effectsSubject(s)
Accidents , Nuclear Medicine , Nuclear Reactors , Power Plants , Radiation Protection , Air Pollutants, Radioactive/adverse effects , Humans , Safety , UkraineABSTRACT
Destructive, inflammatory, sclerotic, compensatory and adaptive, pretumoral and tumoral changes in the respiratory tracts of rats were revealed 180-540 days following a single inhalation of 239PuO2. The thickness of the bronchus wall and the diameter of their lumen remained significantly increased, as compared with the controls of the same age, throughout the entire period of observation.
