ABSTRACT
INTRODUCTION: Lenvatinib mesylate (LEN) is an orally administered tyrosine kinase inhibitor used for the treatment of various cancers, including hepatocellular carcinoma (HCC). HCC treatment with LEN is associated with a very high incidence of adverse events, especially hypothyroidism. This study investigated the incidence of hypothyroidism due to LEN and the relationships between hypothyroidism incidence and patient demographics by analyzing clinical laboratory data from HCC patients treated with LEN. METHODS: This was a single-center, retrospective study of HCC patients who received LEN between April 19, 2018, and September 30, 2020. The observation period was from 1 week before the start of LEN administration to 1 month after the end of administration. RESULTS: In total, 61 patients with HCC were enrolled. High-grade hypothyroidism (CTCAE Grade 2-3) was found in 36.1% (22/61 patients). In high-grade hypothyroidism, eosinophil (EOSINO) count was significantly low (p = 0.029). The cutoff value of EOSINO count was estimated to be approximately 150/µL. The adjusted odds ratios of high-grade hypothyroidism for current smoking and EOSINO count <150/µL were 0.237 (95% confidence interval: 0.063-0.893) and 4.219 (95% confidence interval: 1.119-15.92), respectively. CONCLUSION: The results showed that noncurrent smoking and EOSINO count <150/µL are risk factors for LEN-induced high-grade hypothyroidism.
Subject(s)
Carcinoma, Hepatocellular , Hypothyroidism , Liver Neoplasms , Humans , Carcinoma, Hepatocellular/drug therapy , Carcinoma, Hepatocellular/epidemiology , Retrospective Studies , Liver Neoplasms/drug therapy , Liver Neoplasms/epidemiology , Risk Factors , Hypothyroidism/chemically induced , Hypothyroidism/epidemiologyABSTRACT
We experimentally demonstrate a tunable slow-light device consisting of all-pass Si microrings. A compact device of 0.014 mm2 footprint is fabricated by using CMOS-compatible process, and its center wavelength, bandwidth and delay are continuously tuned by integrated heaters. The tuning range is 300 ps at fixed wavelengths with a 1 nm bandwidth. Eye opening of 40 Gbps non-return-to-zero signals is observed at up to a 150 ps delay and a 4 bit buffering capacity is confirmed, which corresponds to a spatial buffering density of 0.29 kbit/mm2.
