ABSTRACT
Amyloidosis (AL) is a well recognized cause of macroglossia. A case of localized deposition of systemic amyloidosis secondary to multiple myeloma is reported in a 63-year-old female presenting with restricted tongue movement in the dental setting. Amyloidosis secondary to multiple myeloma is well documented in the literature, with amyloid deposits being found at various sites throughout the oral cavity and systemically. This case emphasizes the importance of a full oral soft tissue examination, including the need to examine mobility of the tissues, as it was the restricted movement of the tongue that ultimately alerted the clinician to the diagnosis. This report also highlights other dental implications of managing patients with multiple myeloma and amyloidosis. Clinical relevance: To provide an understanding of what multiple myeloma and amyloidosis are whilst, importantly, relating this to how these conditions can impact on routine dental treatment.
Subject(s)
Amyloidosis/complications , Macroglossia/etiology , Amyloidosis/etiology , Female , Humans , Middle Aged , Movement Disorders/etiology , Multiple Myeloma/complications , Tongue Diseases/etiologyABSTRACT
UNLABELLED: We report a rare genetic condition characterized by gingival hyperkeratosis with skin changes affecting the hands and feet. The patient presented with asymptomatic oral lesions and the diagnosis was reached by taking a full clinical history and biopsy tests. Palmoplantar keratosis can be a feature of a range of different syndromes and can be associated with periodontal destruction, benign oral keratosis or cancer of the oesophagus. It is important for dentists to be aware that clues to diagnosis can be gained from examination of the hands and feet, in addition to an oral examination, particularly in recognizing oral genetic disorders. CLINICAL RELEVANCE: To inform clinicians of both the intra-oral and extra-oral features of focal palmoplantar and gingival hyperkeratosis.
Subject(s)
Gingival Diseases/pathology , Keratoderma, Palmoplantar/pathology , Biopsy , Diagnosis, Differential , Foot Dermatoses/pathology , Humans , Male , Middle Aged , Pedigree , SyndromeABSTRACT
This paper presents a case report of a patient who showed severe oral and skin manifestations of acute idiopathic thrombocytopenic purpura, followed by a discussion of the approach to its differential diagnosis and management in the context of the dental setting.