Poor sleep quality may trigger cognitive deficits after recovery from COVID-19.

Objective: In the present study, we aimed to assess the cognition of post-COVID-19 condition (PCC) participants in relation to their subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI) and to analyse possible moderators of this effect, such as quality of life (European Quality of Life-5 Dimensions, EQ-5D), fatigue (Chadler Fatigue Questionnaire, CFQ), cognitive reserve (Cognitive Reserve Questionnaire, CRC), and subjective cognitive complaints (Memory Failures of Everyday Questionnaire, MFE-30). Methods: We included 373 individuals with PCC and 126 healthy controls (HCs) from the NAUTILUS Project (NCT05307549 and NCT05307575) who were assessed with a comprehensive neuropsychological battery and various questionnaires. Results: We found that PCC participants with poor sleep quality had a 4.3% greater risk of immediate verbal memory deficits than those with good sleep quality, as indicated by the greater odds ratio (OR) of 1.043 and confidence interval (CI) of 1.023-1.063. Additionally, their risk of immediate verbal memory disorders was multiplied by 2.4 when their EQ-5D score was low (OR 0.33; CI 0.145-0.748), and they had a lower risk of delayed visual memory deficits with a greater CRC (OR 0.963; CI 0.929-0.999). With respect to processing speed, PCC participants with poor sleep quality had a 6.7% greater risk of deficits as the MFE increased (OR 1.059; CI 1.024-1.096), and the risk of slowed processing speed tripled with a lower EQ-5D (OR 0.021; CI 0.003-0.141). Conclusion: These results indicate that poor subjective sleep quality is a potential trigger for cognitive deficits. Therapeutic strategies to maximize sleep quality could include reducing sleep disturbances and perhaps cognitive impairment in PCC individuals.

Irreversible electroporation: Beyond the limits of tumor ablation.

Irreversible Electroporation (IRE) is a non-thermal tumor ablation technique. High-voltage electrical pulses are applied between pairs of electrodes inserted around and/or inside a tumor. The generated electric current induces the creation of nanopores in the cell membrane, triggering apoptosis. As a result, IRE can be safely used in areas near delicate vascular structures where other thermal ablation methods are contraindicated. Currently, IRE has demonstrated to be a successful ablation technique for pancreatic, renal, and liver tumors and is widely used as a focal therapeutic option for prostate cancer. The need for specific anesthetic management and accurate parallel placement of multiple electrodes entails a high level of complexity and great expertise from the interventional team is required. Nevertheless, IRE is a very promising technique with a remarkable systemic immunological capability and may impact on distant metastases (abscopal effect).

Electroporación irreversible: ampliando las fronteras de la ablación / Irreversible electroporation: Beyond the limits of tumor ablation

La electroporación irreversible o IRE (irreversible electroporation) es una técnica de ablación tumoral no térmica basada en la aplicación de pulsos eléctricos de alto voltaje entre pares de agujas insertadas alrededor de un tumor. La corriente generada favorece la creación de nanoporos en la membrana plasmática, desencadenando la apoptosis. Por ello, la IRE puede utilizarse de manera segura en localizaciones cercanas a estructuras vasculares delicadas, contraindicadas para el resto de técnicas termoablativas. Actualmente la IRE se emplea con éxito para la ablación de tumores en páncreas, riñón e hígado y, de manera muy extendida, como opción terapéutica focal para el cáncer de próstata. La necesidad de un manejo anestésico específico y la colocación precisa y en paralelo de múltiples agujas implican un alto nivel de complejidad, siendo necesaria una gran experiencia del equipo intervencionista. No obstante, se trata de una técnica muy prometedora con una gran capacidad inmunológica sistémica que puede provocar un efecto a distancia del tumor tratado (efecto abscopal).(AU)

Irreversible electroporation (IRE) is a non-thermal tumor ablation technique. High-voltage electrical pulses are applied between pairs of electrodes inserted around and/or inside a tumor. The generated electric current induces the creation of nanopores in the cell membrane, triggering apoptosis. As a result, IRE can be safely used in areas near delicate vascular structures where other thermal ablation methods are contraindicated. Currently, IRE has demonstrated to be a successful ablation technique for pancreatic, renal, and liver tumors and is widely used as a focal therapeutic option for prostate cancer. The need for specific anesthetic management and accurate parallel placement of multiple electrodes entails a high level of complexity and great expertise from the interventional team is required. Nevertheless, IRE is a very promising technique with a remarkable systemic immunological capability and may impact on distant metastases (abscopal effect).(AU)

Sleep quality in individuals with post-COVID-19 condition: Relation with emotional, cognitive and functional variables.

The study aimed to assess sleep quality in PCC patients and its predictors by analysing its relationship with emotional, cognitive and functional variables, as well as possible differences based on COVID-19 severity. We included 368 individuals with PCC and 123 healthy controls (HCs) from the NAUTILUS Project (NCT05307549 and NCT05307575). We assessed sleep quality (Pittsburgh Sleep Quality Index, PSQI), anxiety (Generalized Anxiety Disorder, GAD-7), depression (Patient Health Questionnaire, PHQ-9), global cognition (Montreal Cognitive Assessment, MoCA), everyday memory failures (Memory Failures of Everyday Questionnaire, MFE-30), fatigue (Chadler Fatigue Questionnaire, CFQ), quality of life (European Quality of Life-5 Dimensions, EQ-5D), and physical activity levels (International Physical Activity Questionnaire, IPAQ). 203 were nonhospitalized, 83 were hospitalized and 82 were admitted to the intensive care unit (ICU). We found statistically significant differences in the PSQI total score between the PCC and HC groups (p < 0.0001), but there were no differences among the PCC groups. In the multiple linear regressions, the PHQ-9 score was a predictor of poor sleep quality for mild PCC patients (p = 0.003); GAD-7 (p = 0.032) and EQ-5D (p = 0.011) scores were predictors of poor sleep quality in the hospitalized PCC group; and GAD-7 (p = 0.045) and IPAQ (p = 0.005) scores were predictors of poor sleep quality in the group of ICU-PCC. These results indicate that worse sleep quality is related to higher levels of depression and anxiety, worse quality of life and less physical activity. Therapeutic strategies should focus on these factors to have a positive impact on the quality of sleep.

CT findings of pulmonary cysts.

Pulmonary cysts are thin-walled radiolucent lesions that may appear in a variety of uncommon disorders known as diffuse cystic lung diseases (DCLD) that essentially includes lymphangioleiomyomatosis (LAM), Langerhans cell histiocytosis (LCH), lymphocytic interstitial pneumonia (LIP), Pneumocystis jiroveci pneumonia (PJP), and Birt-Hogg-Dubé syndrome (BHDS). Moreover, they have been reported in several cases of coronavirus disease 2019 (COVID-19). The purpose of this review is to provide a practical approach for evaluating lung cysts when encountered on CT. We describe the imaging findings of DLCD emphasising their differences in terms of shape and distribution of the cysts, as well as their association with other findings such as nodules or ground-glass opacities, which may help in making a confident diagnosis. We also discuss the link between pulmonary cysts and COVID-19.

Charge-carrier transmission across twins in graphene.

Twinning is a known accommodation mechanism of graphene that results in low-energy microstructures or twins. In view of their mechanical stability, twins suggest themselves as a possible means of introducing extended defects in graphene leading to the opening of transmission band gaps. We investigate charge-carrier transmission across the twin structures in graphene using the Landauer-Büttiker (LB) formalism in combination with a tight-binding model. We verify the approach by means of selected comparisons with density functional theory (DFT) and non-equilibrium Green's function (NEGF) calculations using the code SIESTA and TRANSIESTA. The calculations reveal that graphene twins open transport gaps depending on the twin geometry up to maximum of 1.15 eV. As previously reported for grain boundaries, we find that localized states arise at dislocation cores in the twin boundaries that introduce peaks near the Fermi level.

Pediatric groin lesions: imaging findings. / Lesiones inguinales pediátricas: hallazgos radiológicos.

OBJECTIVES: The groin is a complex anatomic region that has traditionally been ignored by radiologists because most lesions can be diagnosed from clinical data and physical examination. Nevertheless, ultrasound examinations of the groin are increasingly being requested to confirm injury or to resolve diagnostic uncertainty. On the other hand, some conditions involving the groin are found only in pediatric patients. This article describes the key imaging findings in pediatric groin injuries, placing special emphasis on the ultrasound appearance. CONCLUSIONS: Knowledge about conditions that can affect the groin in pediatric patients and the key imaging findings associated with them helps improve the diagnostic performance of ultrasound.

[De novo heterozygous mutation in the MBD5 gene associated with bilateral band heterotopia and polymicrogyria]. / Mutación de novo en heterocigosis en el gen MBD5 asociada a heterotopía en banda bilateral y polimicrogiria.

INTRODUCTION: The aetiology of autosomal dominant mental retardation type 1, also known as pseudo-Angelman, MBD5-associated neurodevelopmental disorder or MBD5 haploinsufficiency, lies in a microdeletion of chromosome 2q23.1 or in a specific alteration of the MBD5 gene, which constitutes the minimum region affected in the aforementioned microdeletion. AIM: To report the case of a girl with a heterozygous de novo mutation in the MBD5 gene associated with bilateral band heterotopia and polymicrogyria. CASE REPORT: We report the case of an 8-year-old girl who was submitted to a developmental follow-up from the age of 18 months after presenting the association of severe intellectual disability and motor delay, lack of language development, segmental hypotonia, a wide forehead and kyphoscoliosis. Magnetic resonance imaging of the brain revealed the presence of a bilateral band heterotopia and parietooccipital polymicrogiria predominant on the left side. In the exome the de novo heterozygous variant c.397+1G>C was detected in the MBD5 gene. CONCLUSION: This is the first observation of a heterozygous mutation in the MBD5 gene associated with a neuronal migration disorder.

TITLE: Mutación de novo en heterocigosis en el gen MBD5 asociada a heterotopía en banda bilateral y polimicrogiria.Introducción. La etiología del retraso mental autosómico dominante 1, también conocido como pseudo-Angelman, trastorno del neurodesarrollo asociado a MBD5 o haploinsuficiencia MBD5, radica en una microdeleción del cromosoma 2q23.1 o en una alteración específica del gen MBD5, que constituye la mínima región afectada en la citada microdeleción. Objetivo. Comunicar el caso de una niña con una mutación heterocigota y de novo en el gen MBD5 asociada a heterotopía en banda bilateral y polimicrogiria. Caso clínico. Niña de 8 años, seguida evolutivamente desde los 18 meses por presentar la asociación de discapacidad intelectual y retraso motor graves, ausencia de desarrollo del lenguaje, hipotonía segmentaria, frente ancha y cifoescoliosis. En la resonancia magnética cerebral se observó la presencia de una heterotopía en banda bilateral y polimicrogiria parietooccipital de predominio izquierdo. En el exoma se detectó la variante de novo c.397+1G>C en heterocigosis en el gen MBD5. Conclusión. Constituye la primera observación con una mutación heterocigota en el gen MBD5 asociada a un trastorno en la migración neuronal.

Mutación de novo en heterocigosis en el gen MBD5 asociada a heterotopía en banda bilateral y polimicrogiria / De novo heterozygous mutation in the MBD5 gene associated with bilateral band heterotopia and polymicrogyria

Introducción: La etiología del retraso mental autosómico dominante 1, también conocido como pseudo-Angelman, trastorno del neurodesarrollo asociado a MBD5 o haploinsuficiencia MBD5, radica en una microdeleción del cromosoma 2q23.1 o en una alteración específica del gen MBD5, que constituye la mínima región afectada en la citada microdeleción. Objetivo: Comunicar el caso de una niña con una mutación heterocigota y de novo en el gen MBD5 asociada a heterotopía en banda bilateral y polimicrogiria. Caso clínico: Niña de 8 años, seguida evolutivamente desde los 18 meses por presentar la asociación de discapacidad intelectual y retraso motor graves, ausencia de desarrollo del lenguaje, hipotonía segmentaria, frente ancha y cifoescoliosis. En la resonancia magnética cerebral se observó la presencia de una heterotopía en banda bilateral y polimicrogiria parietooccipital de predominio izquierdo. En el exoma se detectó la variante de novo c.397+1G > C en heterocigosis en el gen MBD5. Conclusión: Constituye la primera observación con una mutación heterocigota en el gen MBD5 asociada a un trastorno en la migración neuronal

Introduction: The aetiology of autosomal dominant mental retardation type 1, also known as pseudo-Angelman, MBD5-associated neurodevelopmental disorder or MBD5 haploinsufficiency, lies in a microdeletion of chromosome 2q23.1 or in a specific alteration of the MBD5 gene, which constitutes the minimum region affected in the aforementioned microdeletion. Aim: To report the case of a girl with a heterozygous de novo mutation in the MBD5 gene associated with bilateral band heterotopia and polymicrogyria. Case Report: We report the case of an 8-year-old girl who was submitted to a developmental follow-up from the age of 18 months after presenting the association of severe intellectual disability and motor delay, lack of language development, segmental hypotonia, a wide forehead and kyphoscoliosis. Magnetic resonance imaging of the brain revealed the presence of a bilateral band heterotopia and parietooccipital polymicrogiria predominant on the left side. In the exome the de novo heterozygous variant c.397+1G > C was detected in the MBD5 gene. Conclusion: This is the first observation of a heterozygous mutation in the MBD5 gene associated with a neuronal migration disorder

ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain.

INTRODUCTION: Cancer and blood disorders in children are rare. The progressive improvement in survival over the last decades largely relies on the development of international academic clinical trials that gather the sufficient number of patients globally to elaborate solid conclusions and drive changes in clinical practice. The participation of Spain into large international academic trials has traditionally lagged behind of other European countries, mainly due to the burden of administrative tasks to open new studies, lack of financial support and limited research infrastructure in our hospitals. METHODS: The objective of ECLIM-SEHOP platform (Ensayos Clínicos Internacionales Multicéntricos-SEHOP) is to overcome these difficulties and position Spain among the European countries leading the advances in cancer and blood disorders, facilitate the access of our patients to novel diagnostic and therapeutic approaches and, most importantly, continue to improve survival and reducing long-term sequelae. ECLIM-SEHOP provides to the Spanish clinical investigators with the necessary infrastructural support to open and implement academic clinical trials and registries. RESULTS: In less than 3 years from its inception, the platform has provided support to 20 clinical trials and 8 observational studies, including 8 trials and 4 observational studies where the platform performs all trial-related tasks (integral support: trial setup, monitoring, etc.) with more than 150 patients recruited since 2017 to these studies. In this manuscript, we provide baseline metrics for academic clinical trial performance that permit future comparisons. CONCLUSIONS: ECLIM-SEHOP facilitates Spanish children and adolescents diagnosed with cancer and blood disorders to access state-of-the-art diagnostic and therapeutic strategies.

Áreas de mejora en el manejo clínico de la depresión: perspectiva de pacientes, familiares y profesionales / Areas for improvement in the management of depression: perspectives of patients, families and professionals

Introducción. Actualmente existe consenso en que la atención a la depresión requiere entender las experiencias, expectativas y preferencias de los pacientes e incorporar la visión de los profesionales implicados en su manejo. El objetivo de este estudio fue explorar y comparar las perspectivas de pacientes, familiares y profesionales respecto de las principales áreas de mejora de la práctica clínica de la depresión. Material y métodos. Se realizaron 4 grupos focales (2 con pacientes con depresión mayor, uno con familiares y uno con profesionales). Para la captación de los participantes se contó con la colaboración del Servizo Galego de Saúde y de la Federación de Asociaciones de Familiares y Personas con Enfermedad Mental. El contenido de las transcripciones se analizó temáticamente. Resultados. Se identificaron 5 temas principales y 18 subtemas: los retos diagnósticos, la necesidad de un abordaje integral, las mejoras en la coordinación y seguimiento, el establecimiento de un espacio y relación terapéutica adecuados y, por último, el impacto del estigma. Los pacientes, familiares y profesionales aportaron información parcialmente coincidente y complementaria sobre estos temas principales. Conclusiones. El manejo de la depresión es una labor compleja que requiere la puesta en marcha de medidas de diferente naturaleza. Incorporar las perspectivas de los principales agentes implicados es fundamental y se hace patente la necesidad de seguir trabajando en modelos de atención a la depresión que optimicen las experiencias de los pacientes y que tengan en cuenta sus preferencias y expectativas (AU)

Introduction. There is currently a consensus that depression care requires understanding the experiences, expectations, and preferences of patients, and incorporating the views of the professionals involved in its management. The aim of this study was to explore and compare the perspectives of patients, families, and health professionals on the main areas for improvement in the clinical practice of depression. Material and methods. Four focus groups were performed (2 with patients with major depression, one with family members, and one with professionals). Participants were recruited with the collaboration the Galician Health Service and the Federation of Associations of Relatives and Persons with Mental Disease. The content of the transcripts were analysed thematically. Results. Five themes and 18 sub-themes emerged, including, diagnostic challenges, the need for a comprehensive approach, improvements in the coordination and monitoring, the establishment of an adequate relationship and therapeutic space and, finally, the impact of stigma. Patients, families and professionals provided partially overlapping and complementary information on these main themes. Conclusions. The management of depression is a complex task, which requires the implementation of measures of a different nature. The incorporation of the perspectives of key stakeholders is essential and it is necessary to continue working on models of care for depression that optimise the experiences of patients, and take into account their preferences and expectations (AU)

[Areas for improvement in the management of depression: perspectives of patients, families and professionals]. / Áreas de mejora en el manejo clínico de la depresión: perspectiva de pacientes, familiares y profesionales.

INTRODUCTION: There is currently a consensus that depression care requires understanding the experiences, expectations, and preferences of patients, and incorporating the views of the professionals involved in its management. The aim of this study was to explore and compare the perspectives of patients, families, and health professionals on the main areas for improvement in the clinical practice of depression. MATERIAL AND METHODS: Four focus groups were performed (2 with patients with major depression, one with family members, and one with professionals). Participants were recruited with the collaboration the Galician Health Service and the Federation of Associations of Relatives and Persons with Mental Disease. The content of the transcripts were analysed thematically. RESULTS: Five themes and 18 sub-themes emerged, including, diagnostic challenges, the need for a comprehensive approach, improvements in the coordination and monitoring, the establishment of an adequate relationship and therapeutic space and, finally, the impact of stigma. Patients, families and professionals provided partially overlapping and complementary information on these main themes. CONCLUSIONS: The management of depression is a complex task, which requires the implementation of measures of a different nature. The incorporation of the perspectives of key stakeholders is essential and it is necessary to continue working on models of care for depression that optimise the experiences of patients, and take into account their preferences and expectations.

Nondestructive Detection of White Root Rot Disease in Avocado Rootstocks by Leaf Chlorophyll Fluorescence.

White root rot (WRR) disease caused by Rosellinia necatrix is one of the most important threats affecting avocado orchards in temperate regions. In this study, we monitored the progression of WRR disease at the leaf and root levels by the combination of nondestructive chlorophyll fluorescence measurements and confocal laser-scanning microscopy on avocado genotypes susceptible to R. necatrix. Leaf photochemistry was affected at early stages of disease development prior to the appearance of aboveground symptoms, made evident as significant decreases in the trapping efficiency of photosystem-II (Fv'/Fm') and in the steady-state of chlorophyll fluorescence yield (Fs) normalized to the minimal fluorescence yield (F0) (Fs/F0). Decreases in Fv'/Fm' and Fs/F0 were associated with different degrees of fungal penetration, primarily in the lateral roots but not in areas next to the main root collar. Aboveground symptoms were observed only when the fungus reached the root collar. Leaf physiology was also tracked in a tolerant genotype where no changes were observed during disease progression despite the presence of the fungus in the root system. These results highlight the usefulness of this technique for the early detection of fungal infection and the rapid removal of highly susceptible genotypes in rootstock avocado-breeding programs.

La participación: determinante social en la construcción de políticas públicas / Participation: social determinant in the development of public policy

En este artículo se presentan los resultados de una investigación realizada durante 2009 y 2010 con actores políticos, técnicos y sociales, quienes participaron en la Política Pública de Mejoramiento Alimentario y Nutricional de Antioquia (MANA) de la Gobernación de Antioquia, como un modelo de construcción participativa que promueve la salud y el bienestar. OBJETIVO: comprender el proceso de participación de los diferentes actores en el diseño de la Ordenanza No 17 que fija la Política Pública de Mejoramiento Alimentario y Nutricional de Antioquia (MANA). MÉTODOS:utilizando un enfoque cualitativo se hizo un estudio de caso, de tipo interpretativo instrumental. La información obtenida con entrevistas a los actores y revisión documental fue sometida a un análisis de carácter heurístico. RESULTADOS :el proceso fue una participación activa donde los actores, tanto políticos, como técnico-metodológicos y sociales, hacen variados aportes en los diferentes momentos de la construcción de la Política Pública de Mejoramiento Alimentario y Nutricional de Antioquia. CONCLUSIONES:el Plan y la Política se convirtieron en un referente para la construcción de otras políticas, planes o programas similares, fue trascendental por su transformación comunitaria y legitimidad, y aunque tuvo dificultades en el proceso, demostró la importancia del trabajo intersectorial y de una mirada integral frente a problemas sociales tan complejos.

This paper presents the results of a research carried out in 2009 and 2010 with individuals from the political, technical and social fields who participated in the Public Policy for Food and Nutritional Improvement created by the Government of Antioquia. This program was conceived as a model of participatory construction that promotes health and welfare. OBJECTIVE:to understand the participation process of different people in the design of Ordinance 17, which establishes the Food and Nutritional Improvement Public Policy. METHODOLOGY: an interpretive instrumental case study was conducted using a qualitative approach. The information obtained from interviews with the participants and from the literature review was heuristically analyzed. RESULTS:individuals from political, technical-methodological and social areas participated actively in this project. Likewise, they made several contributions at different moments of the construction of the Food and Nutritional Improvement Public Policy for Antioquia. CONCLUSION: The Plan and The Policy became a referent for the construction of other policies, plans or similar programs. They were significant because it transformed the community and was legitimate; even though there were difficulties during the process, they proved the importance of having intersectoral work and an integral view of such complex social problems.

Estenosis del acueducto de Silvio / Aqueductal stenosis

No disponible

Satisfacción y utilidad percibidas por pacientes y familiares acerca de la información sobre prevención de suicidio / Perceived satisfaction and usefulness of suicide prevention information for patients and relatives

Objetivo: Evaluar la satisfacción de personas con conducta suicida y de sus familiares con la información incluida en la «Guía de práctica clínica de prevención y tratamiento de la conducta suicida». Método: Los participantes fueron reclutados a través de un programa de prevención de suicidio (Programa de intervención intensiva en conducta suicida [PII]) y de una Asociación (Federación de Asociaciones de Familiares y Personas con enfermedad mental de Galicia [FEAFES]). Se diseñó un cuestionario ad hoc para conocer el grado de satisfacción y utilidad percibidas con la información incluida en la guía. Resultados: La muestra estuvo formada por 57 pacientes con ideación o conducta suicidas y 52 familiares. Los pacientes puntuaron significativamente más bajo que los familiares en las 2 dimensiones: formato y utilidad; sin embargo, no se encontraron diferencias significativas entre ambos grupos en el nivel de satisfacción general. Las variables sociodemográficas no influyeron en los resultados. Tampoco se encontraron diferencias entre pacientes con y sin antecedentes de conducta suicida. Conclusiones: En general, tanto pacientes como familiares mostraron un alto nivel de satisfacción con el documento. Los participantes destacaron la atención primaria como el ámbito más adecuado para la difusión de este tipo de información. Suministrar información de estas características a pacientes con ideación y/o conducta suicida podría actuar como herramienta preventivo-educativa (AU)

Objective: To assess the satisfaction of persons with suicidal behaviour and their relatives using patient information material included in the Clinical Practice Guidelines on Prevention and Treatment of Suicidal Behaviour. Method: The sample was made up of 57 patients with suicidal ideation or behaviour, and 52 relatives. The participants were recruited through a suicide prevention programme (Programa de intervención intensiva en conducta suicida [PII] - Suicidal Behaviour IntensiveIntervention Programme) and a family association (Federación de Asociaciones de Familiares y Personas con enfermedad mental de Galicia [FEAFES] - Galician Federation of Associations of Relatives and Persons with mental diseases). An ad-hoc questionnaire was designed to ascertain the degree of perceived satisfaction and usefulness of using the information included in the guidelines. Results: The descriptive data of the sample is presented, along with an exploratory factorial analysis of the questionnaire that yielded two dimensions, i.e., format and usefulness. Patients scored significantly lower than the relatives in two dimensions; nevertheless, no significant differences were found between the two groups in the level of general satisfaction. The sociodemographic variables did not influence the results. Similarly, no differences were observed between patients with and without history of suicidal behaviour. Participants stressed that Primary Care was the setting best suited for dissemination of this type of information. Conclusions: In general, both patients and relatives displayed a high level of satisfaction with the patient information material assessed. Furnishing information of this type to patients with suicidal ideation and/or behaviour could act as a preventive-educational tool (AU)

[Perceived satisfaction and usefulness of suicide prevention information for patients and relatives]. / Satisfacción y utilidad percibidas por pacientes y familiares acerca de la información sobre prevención de suicidio.

OBJECTIVE: To assess the satisfaction of persons with suicidal behaviour and their relatives using patient information material included in the Clinical Practice Guidelines on Prevention and Treatment of Suicidal Behaviour. METHOD: The sample was made up of 57 patients with suicidal ideation or behaviour, and 52 relatives. The participants were recruited through a suicide prevention programme (Programa de intervención intensiva en conducta suicida [PII] - Suicidal Behaviour Intensive Intervention Programme) and a family association (Federación de Asociaciones de Familiares y Personas con enfermedad mental de Galicia [FEAFES] - Galician Federation of Associations of Relatives and Persons with mental diseases). An ad-hoc questionnaire was designed to ascertain the degree of perceived satisfaction and usefulness of using the information included in the guidelines. RESULTS: The descriptive data of the sample is presented, along with an exploratory factorial analysis of the questionnaire that yielded two dimensions, i.e., format and usefulness. Patients scored significantly lower than the relatives in two dimensions; nevertheless, no significant differences were found between the two groups in the level of general satisfaction. The socio-demographic variables did not influence the results. Similarly, no differences were observed between patients with and without history of suicidal behaviour. Participants stressed that Primary Care was the setting best suited for dissemination of this type of information. CONCLUSIONS: In general, both patients and relatives displayed a high level of satisfaction with the patient information material assessed. Furnishing information of this type to patients with suicidal ideation and/or behaviour could act as a preventive-educational tool.

Tratamiento anestésico del neonato con atresia de esófago asociada a fístula traqueoesofágica y ano imperforado / Anesthetic management of a neonate with esophageal atresia, tracheoesophageal fistula and imperforate anus

La atresia de esófago es una malformación infrecuente (1:2.500-4.500 recién nacidos vivos), incompatible con la vida y una urgencia quirúrgica neonatal. El 30% de los pacientes son prematuros o presentan bajo peso al nacer y el 50% presentan anomalías asociadas, principalmente cardíacas. Las cardiopatías congénitas de orden mayor o el bajo peso al nacer son predictores independientes de mortalidad y eventos críticos perioperatorios. Presentamos el caso de un paciente intervenido de urgencia de atresia de esófago, fístula traqueoesofágica tipo iii b/C e imperforación anal. El objetivo de este artículo es la exposición de las consideraciones anestésicas en pacientes con esta afección, cuyo complejo manejo perioperatorio supone un importante reto y debe realizarse por equipos multidisciplinares con experiencia en neonatología. Establecer una vía aérea segura y obtener una ventilación pulmonar efectiva que minimice la fuga de aire al tracto digestivo debe ser uno de los objetivos prioritarios del manejo anestésico (AU)

Esophageal atresia is a rare condition (1:2,500-4,500), incompatible with life, and a surgical emergency in the neonatal period. It is associated with prematurity in 30% of cases, and to congenital abnormalities in 50% of cases, especially cardiac anomalies. Major congenital heart diseases and low weight are independent predictors of mortality and critical perioperative events. The aim of this article is to describe the most significant anaesthetic challenges presented in a case of a term neonate undergoing emergency surgery after being diagnosed with esophageal atresia, tracheoesophageal fistula type iiib/C, and imperforate anus. The major priorities during the anaesthetic management consist of establishing a safe airway and effective pulmonary ventilation that minimises air leakage to the upper digestive tract (AU)

Neural responses to visual food cues: insights from functional magnetic resonance imaging.

The aim of this paper is to describe the patterns of functional magnetic resonance imaging activation produced by visual food stimuli in healthy participants, as well as in those with anorexia nervosa, bulimia nervosa, binge eating disorder and obesity. We conducted a systematic review of studies published in the last decade on normal and abnormal eating. This review suggested the existence of neural differences in response to the sight of food between healthy individuals, those with an eating disorder and obese subjects. Differences were identified in two brain circuits: (i) limbic and paralimbic areas associated with salience and reward processes and (ii) prefrontal areas supporting cognitive control processes.