ABSTRACT
Congenital retinoschisis is a bilateral x-linked disease characterized by a stellate maculopathy and retinoschisis. The pathogenesis is unknown. This article describes a patient with congenital retinoschisis and documents the unique development of vascularized vitreous membranes. A posterior vitreous separation with subsequent vascularization of the posterior hyaloid face occurs early in the course of the disease process and is coincident with the development of maculopathy and schisis cavities. This process may represent an important element in the pathogenesis of the maculopathy and schisis cavities in congenital retinoschisis. With atrophy of the neovascular tissue, a membrane remains and consists of a thickened area of the posterior hyaloid face.
Subject(s)
Neovascularization, Pathologic/pathology , Retinal Perforations/congenital , Vitreous Body/blood supply , Aging , Humans , Infant , Macula Lutea/pathology , Male , Membranes/blood supply , Neovascularization, Pathologic/etiology , Retinal Perforations/complications , Retinal Perforations/pathology , Retinal Perforations/physiopathology , Visual AcuityABSTRACT
A 29-year-old white female with peripheral uveitis developed bilateral disc edema and unilateral peripapillary subretinal neovascularization which was successfully treated with argon laser photocoagulation. To our knowledge, this is the first reported case of peripapillary subretinal neovascularization complicating the course of peripheral uveitis.
Subject(s)
Neovascularization, Pathologic/etiology , Retina/blood supply , Uveitis/complications , Adult , Female , Fluorescein Angiography , Humans , Light Coagulation , Neovascularization, Pathologic/diagnosis , Neovascularization, Pathologic/therapy , Papilledema/diagnosis , Papilledema/etiology , Prednisone/therapeutic useABSTRACT
We aimed a high-powered pulsed neodymium-YAG laser incrementally from air to the anterior portion of the vitreous in rabbits to evaluate its effect on the corneal endothelium, the lens, and the dynamics of intraocular fluid. Corneal endothelium damage occurred as much as 3.5 mm away from the site of optical breakdown. The degree of tissue damage was inversely proportional to the distance from the site of optical breakdown, and the damage pattern at a given distance was the same whether the optical breakdown was anterior or posterior to the corneal endothelium. A single 4-mJ shot (mode-locked train) of laser light causes disintegration and liquefaction of the lens in a spherical area 300 micron in diameter. The damage extends posteriorly to a distance of 450 micron. The effect of this explosion denatures the surrounding cortical fibers for an area of 50 to 80 micron. Increased intraocular pressure was noted in all instances of anterior or posterior capsulotomy, probably as a result of the release of liquefied cortical material and mechanical obstruction of the chamber angle. No increase in intraocular pressure occurred when the lens capsule remained intact.
Subject(s)
Corneal Injuries , Lasers/adverse effects , Lens, Crystalline/injuries , Animals , Cornea/pathology , Endothelium/pathology , Eye Injuries/etiology , Eye Injuries/pathology , Glaucoma/etiology , Lens, Crystalline/pathology , Microscopy, Electron, Scanning , Rabbits , Vitreous Body/pathologyABSTRACT
Two patients with a heretofore undescribed unilateral choristomatous malformation of the intracranial optic nerve and chiasm underwent craniotomy for partial resection of the optic nerve in the belief that the tumor was either a glioma or a meningioma. Visual acuity in the affected eye was reduced to 20/200 in one patient and to finger counting in the other. Chiasmal involvement in the first case was associated with a superotemporal field defect in the opposite eye. Ophthalmoscopy disclosed atrophic nerve heads in both affected eyes. Heteroplastic masses of smooth muscle and adipose tissue replaced most of the resected optic nerve in each case.
