[alpha-lipoprotein cholesterol and its variability in ischemic heart disease]. / al'fa-lipoproteidnyi kholesterin i ego izmenchivost' u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The authors conducted a repeated examination of 150 patients suffering from ischemic heart disease with normolipidemia and types IIa, IIb and IV hyperlipoproteinemia. The content of alpha-cholesterol in these patients tended to fluctuate, just as the content of other blood lipid fractions. Its fluctuations were most marked in types 11b and IV hyperlipoproteinemia. Comparison of the alpha-cholesterol content in patients with ischemic heart disease with the results of population tests confirmed the information on its lower level in patients. A still greater difference between patients and healthy individuals was revealed when the percentage of total cholesterol for which alpha-lipoproteines accounted and the value of the cholesterol atherogenic index were compared. Reduced concentration of alpha-cholesterol was encountered not only in hyperlipoproteinemia, but also in normolipidemia. The level of alpha-cholesterol had a negative correlative connection with the content of triglycerides in the blood.

[Comparative lecithin-cholesterol-acyltransferase deficiency in the blood of newborn infants. Comparison of the esterifying activity of neonatal and maternal blood]. / Sravnitel'naia nedostatochnost' letsitin-kholesterin-atsiltransferazy v krovi novorozhdennykh. Sopostavlenie ésterifitsiruiushchei aktivnosti plazmy krovi novorozhdennogo i materi-rozhenitsy.

On the basis of data obtained in studies on the accumulation of cholesterol in erythrocytes of newlorns, the hypothesis is advanced on the deficiency of lecithin-cholesterol-acetyl transferase (LCAT) in the newborn children. A decrease in the rate of the LCAT-reaction was shown in funic blood using the specially developed system "LP-infranatante", the constituents of which were isolated from blood plasma of both newborns and of their mothers by ultracentrifugation at a density 1.21 g/ml and 40.000 rpm. The following factors were considered as possible determinants of the decrease in the rate of cholesterol esterification in blood plasma of newborns: 1) insufficiency in LCAT, 2) alteration in the composition of the substrate lipoproteins (lipoproteins of high density).