ABSTRACT
Bradysole (1 mg/kg intravenously) induced a moderate increase in cerebral bloodflow and a minor decrease in systemic blood pressure in narcotized rats. These effects were less pronounced compared to the effects of dibasole (bradysole structural analog) in the same dose.
Subject(s)
Cerebrovascular Circulation/drug effects , Neurotransmitter Agents/chemistry , Neurotransmitter Agents/pharmacology , Animals , Benzimidazoles/pharmacology , Blood Pressure/drug effects , Blood Pressure/physiology , Cerebrovascular Circulation/physiology , Dose-Response Relationship, Drug , Male , Rats , Rats, Wistar , Sulfhydryl Compounds/pharmacology , Time FactorsABSTRACT
We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.
Subject(s)
Benzimidazoles/pharmacology , Cerebrovascular Circulation/drug effects , Lidocaine/pharmacology , Animals , Dose-Response Relationship, Drug , Male , Rats , Rats, WistarABSTRACT
The effect of the antioxidant mexidol and two new derivatives of 3-oxypyridine, namely LBK-10 and LBK-39 on the circulation of blood and metabolism of the brain in the postischemic period was studied in acute experiments on narcotized cats under conditions of autohemoperfusion of the cerebral vessels with a stable volume of blood. Therapeutic injection of mexidol and LBK in a dose of 20 mg/kg inhibited the development of the no-flow phenomenon and restored the ischemia damaged metabolism in the brain tissues. LBK-10 reduced the lactate content in the blood flowing from the brain and contributed to constriction of the cerebral vessels.
Subject(s)
Antioxidants/therapeutic use , Brain Ischemia/drug therapy , Picolines/therapeutic use , Pyridines/therapeutic use , Animals , Brain/drug effects , Brain/metabolism , Brain Ischemia/metabolism , Brain Ischemia/physiopathology , Cats , Cerebrovascular Circulation/drug effects , Drug Evaluation, Preclinical , Female , Male , Time FactorsABSTRACT
Acute experiments on nembutal anesthetized rats showed improvement of cerebral blood flow autoregulation in the postischemic period under the effect of mexidol and the new 3-hydroxypyridine (3-HOP) derivatives LBK-10 and LBK-38 administered for prophylactic and therapeutic, purposes. The role of dopaminergic activity, solubility in lipids, and other factors in the mechanism of the activity of 3-HOP derivatives is analysed.
Subject(s)
Antioxidants/pharmacology , Brain Ischemia/drug therapy , Cerebral Arteries/drug effects , Homeostasis/drug effects , Picolines/pharmacology , Pyridines/pharmacology , Animals , Antioxidants/administration & dosage , Blood Pressure/drug effects , Brain Ischemia/physiopathology , Cerebral Arteries/physiopathology , Cerebral Veins/drug effects , Cerebral Veins/physiopathology , Cerebrovascular Circulation/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Picolines/administration & dosage , Pyridines/administration & dosage , RatsABSTRACT
The effect of animal cytochrome C (Ca), biotechnological cytochrome (Cb) and its hemtetradecapeptide (HTDP) on cerebral blood flow autoregulation during rapid decrease of systemic arterial pressure (SAP) was studied in acute experiments on rats. Cytochrome C preparations caused no effect on the autoregulatory responses of the cerebral vessels in animals with normal cerebral circulation. Injection of 5 mg/kg Ca and Cb and 0.8 mg/kg HTDP promoted restoration of the phenomenon of cerebral blood flow autoregulation in ischemic brain damage in change of SAP from 120 to 60 mm Hg. Prophylactic injection of 20 mg/kg Ca and Cb and 3.3 mg/kg HTDP prevented cerebral blood flow autoregulation disturbance caused by transitory brain ischemia.
