ABSTRACT
Introducción: La evolución serológica de la sífilis se puede ver influenciada por diferentes factores, entre ellos el VIH. Por este motivo en ocasiones los pacientes positivos para el VIH reciben mayor número de dosis de penicilina (PBG). El objetivo del estudio es describir y comparar la evolución serológica según diferentes factores en pacientes con sífilis precoz en Barcelona. Métodos: El seguimiento serológico se realizó durante 12 meses. El análisis de la evolución hasta el criterio de curación se realizó mediante curvas de Kaplan-Meier. Resultados: De los 208 pacientes incluidos el 97,5% eran HSH y el 42,5% VIH-positivos. La curación se observó a los 99 días de mediana (97-134), sin diferencias según VIH, estadio, títulos de RPR o sífilis previa. Se observó mejor evolución en los pacientes tratados con doxiciclina p = 0,021. Conclusiones: La evolución serológica es similar tanto en pacientes VIH-positivos como en VIH-negativos tratados según las recomendaciones actuales, objetivándose la curación a los 3 meses del tratamiento
Introduction: The evolution of syphilis after treatment could be affected by different factors, for example HIV. In consequence, HIV positive patients are sometimes treated with more doses of penicillin (PBG). The aim of the study is to describe and compare the serological evolution by different actors in patients with early syphilis in Barcelona. Methods: The serological control was made over the following year. A time analysis was performed through the study of Kaplan- Meier curves. Results: The serological control was made in 208 patients, 42.5% of whom were HIV-positive. In a Kaplan-Meier curve the median of days needed to observe the cure was 99 [97-105] without differences depending on HIV, previous syphilis, stage or RPR titters. A better evolution was observed in patients treated with doxycycline P = .02. Conclusions: The serological evolution is similar in HIV-negative and HIV-positive patients treated according to current recommendations, observing the cure at 3 month after treatment
Subject(s)
Humans , Male , Adult , Syphilis Serodiagnosis/methods , Syphilis/diagnosis , Syphilis/microbiology , Syphilis/blood , Kaplan-Meier Estimate , Doxycycline/administration & dosage , Prospective StudiesABSTRACT
INTRODUCTION: The evolution of syphilis after treatment could be affected by different factors, for example HIV. In consequence, HIV positive patients are sometimes treated with more doses of penicillin (PBG). The aim of the study is to describe and compare the serological evolution by different factors in patients with early syphilis in Barcelona. METHODS: The serological control was made over the following year. A time analysis was performed through the study of Kaplan- Meier curves. RESULTS: The serological control was made in 208 patients, 42.5% of whom were HIV-positive. In a Kaplan-Meier curve the median of days needed to observe the cure was 99 [97-105] without differences depending on HIV, previous syphilis, stage or RPR titters. A better evolution was observed in patients treated with doxycycline P=.02. CONCLUSIONS: The serological evolution is similar in HIV-negative and HIV-positive patients treated according to current recommendations, observing the cure at 3 month after treatment.
