1.
Lupus
; 22(9): 961-6, 2013 Aug.
Article
in English
| MEDLINE
| ID: mdl-23894048
ABSTRACT
Poor specific antibody response is a well-known primary immunodeficiency that is related to hypogammaglobulinemia or common variable immunodeficiency (CVID). The co-existence of CVID or hypogammaglobulinemia and systemic lupus erythematosus (SLE) has been rarely described. In all reported cases, the diagnosis of SLE antedates CVID. We report a 15-year-old Saudi girl who was diagnosed with poor specific antibody response at age 6 years in the form of poor or no antibody response and dysgammaglobulinemia. She developed SLE with musculoskeletal and hematological manifestations, positive antinuclear antibody and high anti-dsDNA nine years later. She was treated with rituximab with good response.
Subject(s)
Antibody Formation/immunology , Dysgammaglobulinemia/diagnosis , Lupus Erythematosus, Systemic/diagnosis , Adolescent , Antibodies, Antinuclear/immunology , Antibodies, Monoclonal, Murine-Derived/therapeutic use , Dysgammaglobulinemia/immunology , Female , Humans , Immunologic Factors/therapeutic use , Lupus Erythematosus, Systemic/immunology , Lupus Erythematosus, Systemic/physiopathology , Rituximab , Treatment Outcome
2.
J Allergy Clin Immunol
; 100(6 Pt 1): 850-1, 1997 Dec.
Article
in English
| MEDLINE
| ID: mdl-9438498