Reliability and Validity of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Portuguese Version.

This study examined the test-retest reliability, consensual, convergent and divergent validities, sensitivity, specificity, positive and negative predictive values, and accuracy of the Portuguese version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL). Eighty-nine children/adolescents (65 psychiatric outpatients and 24 healthy controls) were interviewed with K-SADS-PL and completed measures of depressive and anxiety symptoms. The child's parent/caretaker completed the Child Behavior Checklist. Good to excellent values were obtained for test-retest reliability and consensual validity. For the convergent validity, moderate correlations between the K-SADS-PL and the corresponding self-report measures were observed. Divergent validity was acceptable for the K-SADS-PL diagnoses. The lowest values of sensitivity, specificity, and accuracy of the K-SADS-PL were 88, 88, and 91, respectively. The Portuguese version of K-SADS-PL proved to be a valid and reliable assessment instrument for children and adolescents, and was sensitive, specific and accurate when diagnosing mood, anxiety, adjustment, and attention-deficit/hyperactivity disorders.

Polygenic Risk: Predicting Depression Outcomes in Clinical and Epidemiological Cohorts of Youths.

OBJECTIVE: Identifying risk factors for major depression and depressive symptoms in youths could have important implications for prevention efforts. This study examined the association of polygenic risk scores (PRSs) for a broad depression phenotype derived from a large-scale genome-wide association study (GWAS) in adults, and its interaction with childhood abuse, with clinically relevant depression outcomes in clinical and epidemiological youth cohorts. METHODS: The clinical cohort comprised 279 youths with major depression (mean age=14.76 years [SD=2.00], 68% female) and 187 healthy control subjects (mean age=14.67 years [SD=2.45], 63% female). The first epidemiological cohort included 1,450 youths (mean age=13.99 years [SD=0.92], 63% female). Of those, 694 who were not clinically depressed at baseline underwent follow-ups at 6, 12, and 24 months. The replication epidemiological cohort comprised children assessed at ages 8 (N=184; 49.2% female) and 11 (N=317; 46.7% female) years. All cohorts were genome-wide genotyped and completed measures for major depression, depressive symptoms, and/or childhood abuse. Summary statistics from the largest GWAS to date on depression were used to calculate the depression PRS. RESULTS: In the clinical cohort, the depression PRS predicted case-control status (odds ratio=1.560, 95% CI=1.230-1.980), depression severity (ß=0.177, SE=0.069), and age at onset (ß=-0.375, SE=0.160). In the first epidemiological cohort, the depression PRS predicted baseline depressive symptoms (ß=0.557, SE=0.200) and prospectively predicted onset of moderate to severe depressive symptoms (hazard ratio=1.202, 95% CI=1.045-1.383). The associations with depressive symptoms were replicated in the second epidemiological cohort. Evidence was found for an additive, but not an interactive, effect of the depression PRS and childhood abuse on depression outcomes. CONCLUSIONS: Depression PRSs derived from adults generalize to depression outcomes in youths and may serve as an early indicator of clinically significant levels of depression.

FKBP5 moderation of the relationship between childhood trauma and maladaptive emotion regulation strategies in adolescents.

Maladaptive emotion regulation strategies, such as rumination and catastrophizing, are transdiagnostic risk factors for psychopathology. FK506-binding protein 51 (FKBP5) has been found to moderate the relationship between stressful life events and various psychiatric disorders. Given the cross-disorder moderation effect of FKBP5 at the diagnostic level, the aim of the current study was to examine whether the relationship between exposure to childhood trauma and transdiagnostic maladaptive emotion regulation processes would also be moderated by genetic FKBP5 variation in a community sample of adolescents. We hypothesized that adolescent carriers of the FKBP5 CATT haplotype composed of rs9296158, rs3800373, rs1360780, and rs9470080, that has been associated with increased risk for psychiatric disorders in adulthood, would also show higher levels of rumination and catastrophizing. Participants included 1345 genotyped adolescents (Mage=13.95, 64.2% female; 100% European Caucasians of Portuguese descent) who completed self-report measures on exposure to childhood trauma and emotion regulation strategies. Genotypes of rs9296158, rs3800373, rs1360780, and rs9470080 were used to estimate the CATT haplotype (carriers versus non-carriers). Consistent with our hypotheses and previous findings, adolescent CATT haplotype carriers with higher levels of childhood trauma endorsed higher levels of both rumination and catastrophizing compared to non-carriers. Given the association of these maladaptive emotion regulation processes and psychiatric disorders, the findings suggest possible psychological mechanisms why FKBP5 haplotype carriers exposed to childhood trauma are more vulnerable to developing a psychiatric disorder later in life.

Long-term outcome of medically confirmed and self-reported early traumatic brain injury in two nationwide samples.

PRIMARY OBJECTIVES: To assess long-term effects of early traumatic brain injury (TBI) on mental health, cognition, behaviour and adjustment and to identify prognostic factors. METHODS AND PROCEDURES: A 1-year nationwide cohort of all 0-19 year old Icelandic children and adolescents diagnosed with TBI in 1992-1993 (n = 550) received a questionnaire with clinical outcome scales and questions on TBI and socio-economic status (SES) by mail ∼16 years post-injury. A control group (n = 1232), newly selected from the National Registry, received the same questionnaire. Non-respondents answered a shorter version by telephone. Overall participation was 67%. MAIN OUTCOMES AND RESULTS: Medically confirmed and self-reported TBI was reflected in worse outcome. Force of impact, number and severity of TBIs predicted poorer results. Parental SES and demographic factors had limited effects. Not reporting early, medically confirmed TBI did not exclude cognitive sequelae. In self-reported disability, absence of evaluation for compensation was not linked to outcome. CONCLUSIONS: Clinical outcome was consistent with late complaints attributed to early TBI. TBI-related variables had greater prognostic value than other factors. Self-reporting of TBI sustained very early in life needs supplementary information from parents and medical records. More consistency in compensation evaluations following paediatric TBI is indicated.

The scope of early traumatic brain injury as a long-term health concern in two nationwide samples: prevalence and prognostic factors.

PRIMARY OBJECTIVES: To examine the scope of paediatric traumatic brain injury (TBI) as a health concern and to identify prognostic factors for TBI-related sequelae. METHODS AND PROCEDURES: The study was prospective and nationwide. A questionnaire was sent to a study group (SG) of all 0-19 years old in Iceland, diagnosed ∼16 years earlier with TBI during a 1-year period, 1992-1993 (n = 550) and to a control group (CG) (n = 1232), selected from the National Register. MAIN OUTCOMES AND RESULTS: In the CG 49.5% reported having sustained TBI and 7.0% reported long-term disability. In the group with TBI, force of impact to the head, more than one incident of TBI and the injury severity by gender interaction predicted late symptoms. TBI severity had substantially less effect than force of impact and was close to non-existent for females. CONCLUSIONS: Based on two independent nationwide samples, the scope of TBI as a health concern in adolescence and young adulthood is greater than previously documented. The findings suggest that TBI event-related factors, especially force of impact, have greater predictive value than clinical symptoms of severity at the acute stage, females being more sensitive to the effects of mild TBI than males.

Prevention of depression among Icelandic adolescents: a 12-month follow-up.

This paper reports the 12-month follow-up results regarding a program designed to prevent the initial episode of depression and/or dysthymia among Icelandic adolescents. This indicated prevention program was implemented in school settings for 14-15 year-old students judged to be "at risk" for depression because of the presence of some depressive symptoms and/or a negative attributional style. We previously reported (Arnarson & Craighead, 2009) that this program, when compared to treatment-as-usual, was effective in preventing the first episode of depression and/or dysthymia at 6-months following completion of the program. Survival analyses of the 12-month follow-up data indicated that the preventive effects were sustained at the end of 1 year following the completion of the prevention program with only 2 of the prevention program participants reporting an initial episode of MDD/DYS versus 13 of the TAU participants (χ(2)=5.02, p=.025). Using logistic regression, we also found that initial level of depressive symptoms significantly (p=.0330) predicted the first episode of depression and/or dysthymia among TAU subjects. The limitations of the study were noted, and future directions of research regarding prevention of depression were discussed.

[Clinical status and treatment adherence of young adults with type one diabetes mellitus following transition to adult health care]. / Sjúkdómsmynd og medferdarheldni ungs fólks med insúlínháda sykursýki eftir flutning yfir á göngudeild fyrir fullordna.

OBJECTIVE: This paper highlights the treatment factors of concern after the transition from an outpatient clinic for children and adolescents to an outpatient clinic for adults. MATERIAL AND METHODS: Participants were 56 individuals with diabetes type one in their twenties seeking treatment at the Diabetes clinic at Landspítali-University Hospital. In all, 72 outpatients met inclusion criteria and the response rate was 78%. RESULTS: On the average HbA1c measures were above the American Diabetes Association treatment target, which is HbA1c less than 7%. In the preceding twelve months only 28,6% participants attended at least four routine appointments. Half of the women and 30% of the men suffered from complications, retinopathy being most common. Quarter of the participants smoked, which is the same proportion as for all Icelanders aged 20-29 years old. The smokers had more symptoms of depression and anxiety. 19% of participants used psychotropic medication which is more than twice as high as in the normal population of Iceland. CONCLUSIONS: Special attention should be made to the fact that HbA1c measures were on the average above the treatment target and complications were common. Psychotropic medication usage was high which indicates that more cooperation between the Diabetes clinic and psychologists and/or psychiatrists is needed. New methods should be explored in reaching out to young people with diabetes.

Prevention of depression among Icelandic adolescents.

Major depression and dysthymia are frequent, debilitating, and chronic disorders, whose highest rate of initial onset is during the late adolescent years. The effectiveness of a program designed to prevent an initial episode of major depression or dysthymia among adolescents was investigated. Participants were 171 fourteen-year-old "at risk" Icelandic adolescents who were randomly assigned to a prevention program or a treatment-as-usual assessment only control group. They were identified as "at risk" by reporting the presence of depressive symptoms or a negative attributional style. The program was based on a developmental psychosocial model of enhancement of resilience to factors associated with the occurrence of mood disorders. The results indicated that the prevention program resulted in a significantly lower rate of major depression and dysthymia than did the control group. The study demonstrated that school personnel in the school setting can implement such prevention programs.

The prognostic value of injury severity, location of event, and age at injury in pediatric traumatic head injuries.

AIMS: To estimate the prognostic value of injury severity, location of event, and demographic parameters, for symptoms of pediatric traumatic head injury (THI) 4 years later. METHODS: Data were collected prospectively from Reykjavik City Hospital on all patients age 0-19 years, diagnosed with THI (n = 408) during one year. Information was collected on patient demographics, location of traumatic event, cause of injury, injury severity, and ICD-9 diagnosis. Injury severity was estimated according to the Head Injury Severity Scale (HISS). Four years post-injury, a questionnaire on late symptoms attributed to the THI was sent. RESULTS: Symptoms reported were more common among patients with moderate/severe THI than among others (p < 0.001). The event location had prognostic value (p < 0.05). Overall, 72% of patients with moderate/severe motor vehicle-related THI reported symptoms. There was a curvilinear age effect (p < 0.05). Symptoms were least frequent in the youngest age group, 0-4 years, and most frequent in the age group 5-14 years. Gender and urban/rural residence were not significantly related to symptoms. CONCLUSIONS: Motor vehicle related moderate/severe THI resulted in a high rate of late symptoms. Location had a prognostic value. Patients with motor vehicle-related THI need special consideration regardless of injury severity.

[Diabetes type 1 in young adults: The relationship between psycho-social variables, glycemic control, depression and anxiety]. / Ungt fólk med sykursýki tegund 1: Fylgni sálfélagslegra pátta, blódsykursstjórnunar, punglyndis og kvída.

OBJECTIVE: The aim of the present study was to investigate whether psycho-social variables, for example social support and task- and emotion-oriented coping would predict psychological and physical well being among young adults with diabetes. MATERIAL AND METHODS: Participants were 56 individuals in their twenties suffering from type 1 diabetes. Response rate was 78%. The participants came from the whole of Iceland, 64.3% from the Greater Reykjavík area and 33.9% from rural areas. One participant did not indicate his place of residence. Self-assessment scales were used to assess depression, anxiety, task-, avoidance- and emotion-oriented coping, social support and problems relating to diabetes. Additional information was obtained from patients' records concerning the results of blood glucose measurements (HbA1c). RESULTS: Good social support was related to less anxiety and depression and to less self-reported problems related to having diabetes. Emotion-oriented coping was related to not feeling well and task- oriented coping to feeling better. No relationship was found between psychosocial variables and blood glucose measurements and a limited relationship between self-reported problems related to having diabetes and these measurements. CONCLUSIONS: Social support and coping are strongly related to measurements of depression, anxiety and problems related to having diabetes in the present age group. The results indicate that it is very important to teach and strengthen usage, as possible, of task-oriented coping instead of emotion-oriented coping. The results also indicate that social support is highly important for young adults with diabetes type 1. It is clear that friends and family have to be more involved in the treatment and also more educated about the disease and the importance of giving the right kind of support.

Orthodontic treatment experience and prevalence of malocclusion traits in an Icelandic adult population.

INTRODUCTION: The objectives of this study were to record the extent of orthodontic treatment and the prevalence of occlusal anomalies in an adult sample in Iceland. METHODS: The study was based on a random sample of 829 subjects, 342 men and 487 women, aged 31 to 44 years, who completed questionnaires about their orthodontic treatment experiences and were available for clinical examination. RESULTS: Complete dentitions in both jaws were present in 52.8% of the women and 45.3% of the men at the examinations. Significantly higher percentages of the women had received orthodontic treatment of some kind (24.3% compared with 16.9% for the men) and treatment with fixed appliances (16.0% compared with 9.5% for the men). Malocclusion traits were recorded with a standardized method, describing sagittal and vertical incisor relationships, sagittal and transverse molar relationships, and mandibular and maxillary space conditions. The results showed that 45.5% of the subjects had no malocclusions, 33.9% had 1 malocclusion trait, and 20.5% had 2 to 4 traits. The most frequent malocclusion traits were distal molar occlusion (27.7%), mandibular anterior crowding (13.4%), molar crossbite (11.9%), excessive overbite (11.8%), maxillary anterior crowding (7.1%), mesial molar occlusion (6.9%), and excessive overjet (5.3%). The prevalences of mandibular overjet, mesial occlusion, and scissors-bite were significantly higher in the men than in the women. CONCLUSIONS: The prevalences of malocclusion traits were similar in treated and untreated subjects, except for a significantly lower prevalence of overjet and a higher prevalence of molar crossbite in the treated group. Comparison with other studies showed low prevalences of overjet, overbite, open bite, and maxillary and mandibular spacing and crowding; other variables fell within the ranges of prevalence in previous surveys.

Urban-rural differences in pediatric traumatic head injuries: A prospective nationwide study.

AIMS: To estimate differences in the incidence of recorded traumatic head injuries by gender, age, severity, and geographical area. METHODS: The study was prospective and nationwide. Data were collected from all hospitals, emergency units and healthcare centers in Iceland regarding all Icelandic children and adolescents 0-19 years old consecutively diagnosed with traumatic head injuries (N = 550) during a one-year period. RESULTS: Annual incidence of minimal, mild, moderate/severe, and fatal head injuries (ICD-9 850-854) was 6.41 per 1000, with 95% confidence interval (CI) 5.9, 7.0. Annual incidence of minimal head injuries (ICD-9 850) treated at emergency units was 4.65 (CI 4.2, 5.1) per 1000, mild head injuries admitted to hospital (ICD-9 850) was 1.50 (CI 1.3, 1.8) per 1000, and moderate/severe nonfatal injuries (ICD-9 851-854) was 0.21 (CI 0.1, 0.3) per 1000. Death rate was 0.05 (CI 0.0, 0.1) per 1000. Young children were at greater risk of sustaining minimal head injuries than older ones. Boys were at greater risk than girls were. In rural areas, incidence of recorded minimal head injuries was low. CONCLUSIONS: Use of nationwide estimate of the incidence of pediatric head injury shows important differences between urban and rural areas as well as between different age groups.

Dental anxiety in Iceland: an epidemiological postal survey.

In this study, we examined the prevalence of specific (dental) phobia among a sample of the Icelandic population. In addition to dental anxiety we explored factors that could be related to dental anxiety. In the period 1972-73, a stratified sample of 1641 schoolchildren in Reykjavík was selected for a study on malocclusion, dental maturation and other factors. Twenty-two years later (1995), a postal survey conducted in this group looked at many variables relating to oral health, including orofacial pain, functional oral disorders, self-perception of dental and general appearance and need for orthodontic treatment. Out of 1529 individuals contacted, 1192 completed questionnaires were returned (response rate 78%). Questions based on DSM-IV criteria of specific (dental) phobia (DP) were included. Ninety-six participants reported that they had avoided dental treatment during the previous 6 months. Twenty-one respondents fulfilled DSM-IV criteria for specific (dental) phobia (DP) and 75 admitted to many symptoms of dental anxiety (DA). Specific (dental) phobia (DP) was more prevalent among women than among men. The divorced or widowed were most at risk, as were non-salaried respondents. Most respondents attributed the onset of their phobias to a specific painful or fearful experience. There was a significant difference between the total dentally anxious (TDA = DA + DP) and the not dentally anxious (NDA) with regard to sex (women--higher TDA) and marital status (divorced or widowed--higher TDA). The TDA had statistically fewer teeth than the NDA and received dental treatment less frequently.