Subject(s)
Agranulocytosis/surgery , Leukemia, Large Granular Lymphocytic/diagnosis , Remission Induction/methods , Splenectomy , Splenomegaly/surgery , Agranulocytosis/diagnosis , Agranulocytosis/etiology , Humans , Leukemia, Large Granular Lymphocytic/complications , Male , Middle Aged , Spleen/diagnostic imaging , Spleen/pathology , Spleen/surgery , Splenomegaly/diagnostic imaging , Splenomegaly/etiology , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
In case of a new breast symptom or an abnormal result of breast imaging, some women have a problem finding a quick answer to allay their anxiety. The Institut Sainte-Catherine in Avignon has set up a new form of accelerated disease management through the opening of a new dedicated consultation called SOS SEIN 84. We present the result of a prospective quality study of our first new patients.
Subject(s)
Anxiety/prevention & control , Anxiety/psychology , Breast Diseases , Breast Neoplasms , Disease Management , Patient Satisfaction , Adult , Aged , Aged, 80 and over , Breast Diseases/diagnosis , Breast Diseases/diagnostic imaging , Breast Diseases/psychology , Breast Neoplasms/diagnosis , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/psychology , Female , Humans , Middle Aged , Program Evaluation , Prospective Studies , Surveys and Questionnaires , Symptom Assessment , Time FactorsSubject(s)
Abnormal Karyotype , Gene Deletion , Leukemia, Myeloid, Acute/genetics , Monosomy , Tumor Suppressor Protein p53/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Male , Middle Aged , Prognosis , Young AdultABSTRACT
BACKGROUND: Only a few studies have used in/opposed phase method for a quantitative evaluation of fat fraction in the spine. PURPOSE: To compare multivoxel proton MR spectroscopy and chemical-shift gradient-echo MR imaging for bone marrow fat quantification in vertebral compression fractures (VCF). MATERIAL AND METHODS: Vertebral marrow fat quantification in fifteen patients was measured at 3.0-T. Multi-voxel proton spectroscopy (MRS) and in/opposed-phase MR imaging using a fat map build with a triple-echo gradient-echo sequence was used. All the patients had benign vertebral collapse. Bone marrow fat content was evaluated by both techniques in compressed (acute or chronic) and in non-compressed vertebrae. RESULTS: The percentage of fat fraction measured by the triple-echo sequence was well correlated with those calculated by MRS (r(2) = 0.85; P < 10(-4)). There was a significant decrease of fat fraction in acute VCF versus both chronic VCF (P < 10(-9)) and non-fractured vertebrae (P < 10(-7)). There was no significant difference in fat fraction evaluated by both techniques between non-fractured vertebrae and chronic VCF. CONCLUSION: We have validated the in/opposed phase method compared with MRS for vertebral bone marrow fat quantification. The fat mapping using a triple-echo gradient-echo sequence allows distinguishing acute and chronic benign VCF.
Subject(s)
Bone Marrow/chemistry , Fractures, Compression/metabolism , Lipids/analysis , Magnetic Resonance Imaging/methods , Magnetic Resonance Spectroscopy/methods , Osteoporosis/metabolism , Spinal Fractures/metabolism , Acute Disease , Adult , Aged , Aged, 80 and over , Chronic Disease , Female , Humans , Male , Middle AgedABSTRACT
We report the case of a 54-year-old patient presenting with a typical pernicious anaemia. His mother was diagnosed with unquestionable pernicious anaemia 5 years previously. Serum ferritin was strongly increased (1,160 microg/l, normal range 29-380), with a transferrin saturation of 95%. We found a homozygous C282Y mutation of the HFE gene in our patient, his mother being heterozygous. The son of our patient was compound C282Y/H63D heterozygous without detectable pernicious anaemia. This seems to be the first report of an association between familial pernicious anaemia and hereditary haemochromatosis. The simultaneous occurrence of the 2 diseases in the same patient helps to delineate the relative contribution of each of them to iron metabolism and erythropoiesis: iron overload was only moderately increased and responded rapidly to phlebotomies, whereas haemochromatosis did not modify the cytologic presentation of pernicious anaemia.
