ABSTRACT
Amyloidosis primarily involving bone is described in a 59-year-old male pateint. Well circumscribed lytic lesions of the skeleton raised the possibility of myelomatosis. The prolonged insidious course of the disease was uncomplicated by hypercalcemia, pathological fracture, or hematologic abnormalities. The clinical course, together with histological findings and strongly positive bone scan, were the distinguishing features. The osseous manifestations without plasma cell tumor appears to be a rare occurrence in amyloidosis.
Subject(s)
Amyloidosis/complications , Bone Resorption/complications , Osteolysis/complications , Acid Phosphatase/blood , Amyloidosis/mortality , Amyloidosis/pathology , Bone and Bones/metabolism , Humans , Male , Middle Aged , Osteolysis/pathology , Paraproteinemias/complications , Serum Amyloid A Protein , TechnetiumABSTRACT
A rare case of rapidly evolving dysgerminoma produced death by tumor in less than two months after onset of symptoms. It is important to recall that dysgerminoma possesses considerable malignant potential, which infrequently is manifested by rapidly progressive disease. Certain risk factors, present in the pathological specimen, serve to indicate the aggressive potential of such neoplasms.
