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J Ethnopharmacol ; 82(2-3): 155-8, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12241990

ABSTRACT

In our efforts to find new active tyrosinase inhibitors for skin-whitening or antibrowning preparations, we investigated 67 tropical plants belonging to 38 families, which were evaluated for their anti-tyrosinase activity. The results of our investigation show that extracts of 5 plants, Stryphnodendron barbatimao, Portulaca pilosa, Cariniana brasiliensis, Entada africana and Prosopis africana present interesting in vitro mushroom tyrosinase inhibition (over 90%), similar to a positive control: Morus alba. These 5 plants will be studied in order to isolate and identify phytochemical compounds, involved in this biological activity.


Subject(s)
Drug Evaluation, Preclinical/statistics & numerical data , Enzyme Inhibitors/pharmacology , Monophenol Monooxygenase/antagonists & inhibitors , Plant Extracts/pharmacology , Agaricales/enzymology , Drug Evaluation, Preclinical/methods , Enzyme Inhibitors/isolation & purification , Monophenol Monooxygenase/metabolism , Plant Extracts/isolation & purification , Plant Structures
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