Comparison of the efficacy and safety of two formulations of diclofenac sodium 0.1% eyedrops in controlling postoperative inflammation after cataract surgery.

PURPOSE: To compare the efficacy and safety of diclofenac sodium 0.1% eyedrops packaged in an Abak multidose container without preservative (Dicloabak) with the reference product, sodium merthiolate-preserved diclofenac sodium 0.1% eyedrops, in controlling postoperative inflammation after cataract surgery. METHODS: The multicenter, controlled, randomized, single-masked study included 194 patients (Dicloabak 96, preserved diclofenac 98) scheduled to have cataract surgery by phacoemulsification with foldable intraocular lens. All were evaluated preoperatively and postoperatively after 1, 7, and 28 days. Postoperative inflammation was measured by the total score of anterior chamber cells and flare. Ocular plin, conjunctival hyperemia and ciliary flush were also assessed. Postoperative patient assessments also included visual acuity, objective tolerance by slit-lamp, fluorescein test, and subjective evaluation of local tolerance. RESULTS: There was no statistically significant difference between the groups in the total score of flare and cells or the degree of conjunctival hyperemia and ciliary flush at any study visit. Dicloabak was demonstrated to be not inferior to preserved diclofenac at all assessment times. The overall assessment of local tolerance was similar for both study medications. CONCLUSIONS: Preservative suppression did not alter diclofenac efficacy. Results support the good safety profile of both formulations when dosed three times daily for 4 weeks in absence of concomitant use of drugs potentially toxic for cornea. Preservative-free formulations like Dicloabak should be preferred to generic diclofenac formulations including other ingredients and may improve the safety profile of this topical nonsteroid anti-inflammatory drug.

[Bucco-sinusal site of primary leiomyosarcoma]. / Localisation bucco-sinusienne d'un leiomyosarcome primitif.

The leiomyosarcoma, a malignant smooth muscle tumor, is common in uterus and gastro intestinal track. Only 27 cases of oral cavity localisation have been report in literature since 1908. We report a case of primary leiomyosarcoma of palate in 26 years old woman. The diagnosis is made by histopathological examination after biopsy. The extension is revealed by clinical symptoms and scan examination. The treatment is based on wide surgery Chemotherapy and radiotherapy could be proposed. The prognosis of the lesion depends of metastatic development, few cases have been present with metastases developed after one year, two years and five years. Generally their localisation are liver, lungs or lymph nodes. In our case after two years post operative a second lesion is revealed and the patient died quickly.

[Extended pleiomorphic adenoma of the hard palate. Apropos of a case]. / Important adénome pléomorphe de la voûte palatine. A propos d'un cas.

A patient presented with a large pleomorphic adenoma of roof of mouth measuring 6.5 cm in diameter and weighing 90 grams. Surgical exeresis was by simple enucleation with immediate covering of the roof of mouth by an extemporaneous palatine plate fixed with transcortical screws, this allowing rapid institution of normal feeding and reduction of postoperative management.

[Value of manubriotomy in extensive thyroid surgery. 11 cases (author's transl)]. / Intérêt de la manubriotomie dans la chirurgie extensive du corps thyroïde. A propos de 11 cas.

Manubriotomy was performed in 11 cases of retrosternal goitre or extensive thyroid cancers. The advantages of this method, which is described in detail, are that sternotomy can be avoided in the majority of cases, and that the postopeuative period is particularly straightforward.