[Effect of thrombopenia on bone marrow CFU-S level and its capability to modify the circulating thrombocyte number]. / Die Auswirkung der Thrombopenie auf den CFU-S-Gehalt des Knochenmarks und seine Fähigkeit zur Beeinflussung der zirkulierenden Thrombozytenzahl.

Thrombocytopenia (rise of the thrombopoietin level) was induced by an antithrombocyte serum in mice. After 6 hours of existence of thrombocytopenia, the CFU-S and megakaryocyte-commmitted stem cell content of the bone marrow and spleen was determined by transplantation into mice pretreated with 800 cGy-rtg irradiation. Thrombocytopenia did not influence the CFU-S content. Thrombocytopoiesis of the recipient mice was better restored by bone marrow and spleen cells of thrombocytopenic animals than by cells transplanted from animals with a normal thrombocyte count.

[Thrombopoietic activity induced by blood withdrawal and administration of antithrombocyte serum in nephrectomized rats. Role of kidneys in the production of thrombopoietin]. / Untersuchung der durch Blutentzug und Gaben von Antithrombozytenserum erzeugten thrombopoetischen Aktivität bei nephrektomierten Ratten. Zur Rolle der Niere bei der Erzeugung von Thrombopoetin.

The thrombopoietic serum activity was examined in rats during thrombocytopenia produced by bleeding or after treatment with antithrombocyte serum (ATS). 6 hours after both treatments the thrombopoietic activity of the serum, i.e. its content of thrombopoietin, is increased. After the ATS treatment of nephrectomized animals a similar increase of thrombopoietic activity as in normal animals could be achieved. In contrast to that, no similar increase of thrombopoietic activity was observed in nephrectomized animals after blood loss. According to the results of the authors the increase of thrombopoietic activity produced by different stimuli can be attributed to different mechanisms.