ABSTRACT
Hemodynamic instability and arrhythmia after cardiopulmonary bypass occasionally requires delayed sternal closure or placement of a stenting device. A primary sternal closure with autologous inlay rib grafts can ensure a secure, stable sternal repair and avoids prolonged ventilator support and the concerns, risks, and expense associated with a secondary sternotomy repair.
Subject(s)
Bone Transplantation , Coronary Artery Bypass , Sternum/surgery , Aortic Valve/surgery , Arrhythmias, Cardiac/etiology , Edema/etiology , Humans , Hypotension/etiology , Intraoperative Complications , Male , Mediastinum/physiopathology , Methods , Middle Aged , Postoperative Complications/prevention & control , Pressure , RibsSubject(s)
Lung Neoplasms/surgery , Adenocarcinoma/diagnosis , Adenocarcinoma/etiology , Adenocarcinoma/surgery , Adenocarcinoma, Bronchiolo-Alveolar/diagnosis , Adenocarcinoma, Bronchiolo-Alveolar/etiology , Adenocarcinoma, Bronchiolo-Alveolar/surgery , Aged , Carcinoma, Papillary/diagnosis , Carcinoma, Papillary/etiology , Carcinoma, Papillary/surgery , Carcinoma, Small Cell/diagnosis , Carcinoma, Small Cell/etiology , Carcinoma, Small Cell/surgery , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/surgery , Female , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/etiology , Male , Middle Aged , Prognosis , SmokingABSTRACT
A 26-year-old man, acutely ill with fever, anemia, and hepatomegaly, was found to have an epidermoid carcinoma by percutaneous needle biopsy of a left apical lung mass. Following resection of the necrotic tumor, fever, anemia, and hepatomegaly disappeared. The patient is alive with no evidence of cancer 30 months later.
Subject(s)
Anemia/complications , Carcinoma, Squamous Cell/complications , Fever/complications , Hepatomegaly/complications , Lung Neoplasms/complications , Biopsy, Needle , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Humans , Lung Neoplasms/pathology , Lung Neoplasms/surgery , Male , Middle Aged , PrognosisABSTRACT
The interaction between the antibiotic bleomycin and x-radiation has been studied in vitro and in vivo. Tissue culture results appear to reflect in vivo sensitivities correctly. Simultaneous exposure to bleomycin and gamma radiation enhances killing of both sensitive and resistant lines. Data from a pilot study combining bleomycin with conventional radiation for unresectable squamous cell carcinoma of the lung suggest that the simultaneous administration of bleomycin (10 mg/m2 intravenously twice weekly) with short-course radiation treatment is well tolerated and without dangerous pulmonary complications. Tumor response was greater in the combined-therapy group (46%) than in radiation-only controls (26%); median survivals were 13 and 6 months, respectively. Unlike previously published data, responders appeared to have a significant survival advantage over nonreponders, suggesting that bleomycin may be slightly effective in inhibiting the development of systemic metastasis, and that it positively enhanced local control of primary disease.
