[Intracranial tuberculoma: clinical and pathological aspects]. / Tuberculomas intracranianos: estudo clínico e patológico.

A retrospective analysis of 19.760 consecutive autopsies and 72.972 biopsies in a period of over 41 years disclosed 24 intracranial tuberculomas in 17 patients, representing 4,2% of the intracranial space-occupying lesions. Most intracranial tuberculomas were found the cerebral hemispheres whereas one third of them were located in the cerebellum. About two thirds of the patients were younger than 20 years old. The clinical picture of intracranial tuberculomas is similar to that of other space-occupying lesions, comprising signs of raised intracranial pressure and signs related to the anatomical site of the lesion.

Tuberculomas intracranianos: estudo clinico e patologico. / Intracranial tuberculoma: clinical and pathological aspects

Vinte e quatro tuberculomas intracranianos foram encontrados em 17 pacientes numa analise retrospectiva de 19.760 autopsias e 72.972 biopsias consecutivas, num periodo de 41 anos e 4 meses. Os 17 pacientes representaram 4,2% dos casos das lesoes expansivas intracranianas. A maioria dos tuberculomas se localizava nos hemisferios cerebrais, e um terco deles, no cerebelo. Cerca de 65% dos pacientes tinham idade inferior a 20 anos. O quadro clinico e semelhante ao das outras lesoes expansivas intracranianas estando relacionado a hipertensao intracraniana e a localizacao da lesao. Os dados encontrados sao comparados aos das varias series publicadas em diferentes paises

[Primary intracranial tumors: analysis of a series of consecutive autopsies and biopsies]. / Tumores primários intracranianos: análise de uma série de autopsias e biopsias consecutivas.

A retrospective study of primary intracranial tumors found in 19.760 consecutive autopsies and 72.972 consecutive biopsies during a period of over 41 years was carried out. Two hundred and five neoplasms comprising 69,7% of the primary intracranial tumors were located in the supratentorial compartment whereas 84 tumors (28,6%) were infratentorial in site. Gliomas constituted the largest group of primary tumors comprising 60,9% of the intracranial primary neoplasms. Most of gliomas were found in the cerebral hemispheres, particularly in the frontal lobes. Of the total number of gliomas 40,2% were astrocytomas, 29,6% glioblastomas, 10,6% ependymomas, 10,1% medulloblastomas, 5% oligodendrogliomas and 2,2% choroid plexus papillomas. Meningiomas constituted the second most common primary intracranial tumors being found in 56 cases (19%), most of them in parasagittal region, sphenoid ridge and anterior fossa. In the sella region there were 39 neoplasms including 21 pituitary adenomas, seven meningiomas, five craniopharyngiomas, four epidermoid cysts and two teratomas. Six capillary hemangioblastomas of the cerebellum and two chordomas of the clivus were also found. Sixty-five tumors occurred in patients under 15 years of age, 53,3% of them infratentorial in location--36% in the cerebellum, 9,3% in the brainstem and 8% in the fourth ventricle. The majority of these tumors were astrocytomas, medulloblastomas and ependymomas. The present data are discussed in relation to other pathological series found in the literature.

Tumores primarios intracranianos: analise de una serie de autopsias e biopsias consecutivas. / Primary intracranial tumors: analysis of a series of consecutive autopsies and biopsies

Entre 19.760 autopsias e 72.972 biopsias consecutivas, num periodo de 41 anos e 4 meses, foram encontrados 294 tumores intracranianos primarios representando 74,8% das lesoes expansivas intracranianas. Cerca de dois tercos destes tumores se localizavam no compartimento supratentorial. Os gliomas foram os tumores mais frequentemente observados, seguidos pelos meningiomas, adenomas hipofisarios, tumores de origem embrionarias e tumores vasculares. Na regiao selar foram diagnosticados 39 tumores, incluindo os tumores intracelares supraselares e paraselares. A maior parte destes tumores foi constituida pelos adenomas hipofisarios, seguidos pelos craniofaringiomas, meningiomas, cistos epidermoides e teratomas. Setenta e cinco tumores foram verificados em pacientes com idade inferior a 15 anos,sendo a maioria deles na fossa posterior, principalmente no cerebelo. Estes tumores foram representados pelos astrocitomas do cerebelo e tronco encefalico, meduloblastomas e ependimomas do quarto ventriculo. Os dados obtidos foram comparados com as varias series encontradas na literatura