Labdanes, Withanolides, and Other Constituents from Physalis nicandroides.

Chemical investigation of the aerial parts (except fruits and calixes) of Physalis nicandroides var. attenuata led to the isolation of a series of new labdane-type diterpenoids, including the closely related compounds 1-3, the labdane glucosides 4 and 5, a mixture of the epimeric alcohols 6 and 7, and one labdanetriol, isolated as its tri-O-acetyl derivative 9. In addition, three new withanolides (14-16) and six known compounds were isolated. The structures of these compounds were elucidated by analysis of their spectroscopic data and chemical transformations, and those of compounds 1, 4, and 16 were confirmed by X-ray diffraction analysis of the natural product (1) and of the corresponding acetyl derivatives 4a and 16a. Fourteen of these compounds were assayed for their in vitro inhibitory activity against yeast α-glucosidase and acetylcholinesterase enzymes. The results were negative in both cases, except for compound 3a that marginally inhibited the activity of acetylcholinesterase with an IC50 value of 64.4 µM.

Secuencia de perfusion arterial reversa (TRAP) / Twin Reversed Arterial Perfusion, TRAP

Resumen:Considerada como una complicación exclusiva de gestaciones múltiples monocoriales, la secuencia de perfusión arterial reversa se caracteriza por la presencia de un feto malformado que tiene un corazón rudimentario o ausente, con una perfusión desde el gemelo estructuralmente normal hacia el feto acárdico y una mortalidad del 100% en el feto acárdico y el 50% en el feto sano. Se reporta un caso clínico de una paciente de 15 años con embarazo gemelar monocorial de 27 semanas, referida al Hospital San Juan de Dios, en donde se le dio seguimiento diario con ultrasonido y se documentó el patrón ultrasonógrafico anormal de sumación-colisión. A los 7 días de ingreso se decide la interrupción del embarazo por sospecha de coriamnioitis, naciendo un producto viable y otro polimalformado.

Abstract:Considered an exclusive complication of monochorionic gestations, the TRAP sequence is characterize by the presence of a malformed fetus with a rudimentary or absent heart, in which there is an perfusion from the structurally normal twin to the acardiac fetus and a 100% mortality in the acardiac fetus and 50% in the healthy one. We present a clinical case of a 15 years old patient with monochorionic twin pregnancy of 27 weeks, referred to Hospital San Juan de Dios, where daily monitoring with ultrasound was done and an abnormal collision-summantion pattern was documented and reported. After 7 days of admission chorioamnionitis was suspected and termination of the pregnancy was decided resulting in a viable product and another with multiple malformations.