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Vet Res Commun ; 48(3): 1921-1927, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38453822

ABSTRACT

Exocrine pancreatic carcinomas are rarely reported in dogs. A ductal pancreatic adenocarcinoma in a 10-year-old intact beagle is described in this report. The diagnosis was made based on clinical signs, imaging (abdominal ultrasound and CT scan) and histopathology. Treatment consisted of partial right lobe pancreatectomy followed by adjuvant therapy with toceranib phosphate (Palladia®) and firocoxib (Previcox®) for six months. The treatment was well tolerated, and the survival time was 445 days. To our knowledge, this is the longest survival reported in the literature for a dog diagnosed with exocrine pancreatic adenocarcinoma. The results described here may contribute to provide a better understanding about this neoplasia and potential treatment options.


Subject(s)
4-Butyrolactone , Dog Diseases , Indoles , Pancreatic Neoplasms , Pyrroles , Sulfones , Animals , Dogs , Dog Diseases/drug therapy , Dog Diseases/surgery , Dog Diseases/diagnostic imaging , Pancreatic Neoplasms/veterinary , Pancreatic Neoplasms/surgery , Pancreatic Neoplasms/drug therapy , 4-Butyrolactone/analogs & derivatives , 4-Butyrolactone/therapeutic use , Indoles/therapeutic use , Indoles/administration & dosage , Pyrroles/therapeutic use , Pyrroles/administration & dosage , Sulfones/therapeutic use , Adenocarcinoma/veterinary , Adenocarcinoma/drug therapy , Adenocarcinoma/surgery , Pancreatectomy/veterinary , Male , Antineoplastic Agents/therapeutic use
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