Effectiveness of the booster dose of COVID-19 vaccine in the Basque Country during the sixth wave: A nationwide cohort study.

The aim of the study was to assess the effect of a booster dose of COVID-19 vaccine on the rates of hospital ward and intensive care unit (ICU) admissions around the time of emergence of the Omicron variant in the Basque Country. A retrospective cohort population-based study was conducted. The population with any records related to COVID-19 vaccination up to 28 February 2022 was classified into four cohorts by vaccination status. For every cohort, the hospital ward and ICU admission rates were calculated for each day between November 2021 and February 2022. Generalized linear models with a negative binomial distribution were used to estimate the age-adjusted hospitalization rate ratio of the cohort of individuals who had received a booster compared to the other cohorts. The age-adjusted rates of hospital ward and ICU admissions were 70.4 % and 72.0 % lower, respectively, in the fully vaccinated plus booster group compared to the fully vaccinated but no booster group. Analysing changes in the 14-day admission incidence rates showed that as the prevalence of the Omicron variant increased, the corresponding rate ratios decreased. The immunity acquired with the booster dose allowed the hospital network to meet all the demand for hospitalization during a period of high incidence of COVID-19, despite the fact that vaccine protection decreased as the prevalence of the Omicron variant increased.

Brief cognitive tests as a decision-making tool in primary care. A population and validation study.

INTRODUCTION AND OBJECTIVES: Brief cognitive tests (BCT) are used in primary care (PC) for the detection of cognitive impairment (CI). Still, there are little data on their diagnostic utility (DU) in a community setting. This work evaluates the DU at the population level of Fototest, T@M, AD8 questionnaire and MMSE. It provides new cut-off points (CoP) validated in a CI early detection program. MATERIAL AND METHODS: In the population and validation samples, the evaluation was carried out in two phases, a first of screening and administration of BCT and a second of clinical diagnosis, blinded to the results of the BCT, applying the current NIA-AA criteria. The DU of BCT in the population sample was evaluated with the area under the ROC curve (aROC). Youden index and the CoP with the best specificity that ensured a sensitivity of 80% were used to decide on the most appropriate CoP. The sensitivity, specificity, and predictive values for these CoP were calculated in the validation sample. RESULTS: 260 participants (23.1% with CI) from the population sample and 177 (42.4% with CI) from the validation sample were included. The Fototest has the best UD at the population level (aROC 0.851), which improves with the combination of Fototest and AD8 (aROC 0.875). The proposed CoP are AD8 ≥ 1, Fototest ≤ 35, T@M ≤ 40, and MMSE ≤ 26. CONCLUSION: BCT are helpful in detecting CI in PC. This work supports the use of more demanding PoC.

La dieta como factor de riesgo de hipovitaminosis D en la población pediátrica española / Diet as a risk factor for hypovitaminosis D in the Spanish pediatric population

Objetivo: El papel de la dieta como determinante relevante de hipovitaminosis D no está claro. El objetivo del estudio fue analizar su impacto en la prevalencia de hipovitaminosis D en población infantil sana española. Métodos: Mediante un diseño observacional se estudiaron en una muestra de población pediátrica, entre 4 y 14 años, datos demográficos, antropométricos, nutricionales, analíticos y el nivel de 25(OH) D mediante enzimo-inmuno-análisis. Se obtuvieron encuestas dietéticas mediante recordatorio de 24 horas evaluadas mediante el programa informático DietSource 3.0. La probabilidad de hipovitaminosis se analizó mediante regresión logística. Resultados: Se reclutaron 281 niños sanos con una edad media 9,0 años. La prevalencia de hipovitaminosis D (<20 ng/ml) fue de un 18,15% y la de déficit grave (<10 ng/ml) del 1,4%. La etnia, la estacionalidad, el fototipo de piel y el tiempo de exposición solar se asociaron significativamente a la presencia de hipovitaminosis D. La distribución de nutrientes no mostró diferencias entre los grupos con y sin hipovitaminosis salvo en la Piridoxina (vitamina B6) y los ácidos grasos saturados. Conclusiones: La dieta juega un papel reducido como factor de riesgo de hipovitaminosis D en población infantil sana y los factores relevantes son los relacionados con la exposición al sol. Un adecuado estilo de vida al aire libre, exposición solar libre de protectores solares y patrones dietéticos que aseguren una ingesta correcta de vitamina D y calcio siguen siendo las recomendaciones idóneas para la población general. La utilización de suplementos se debe limitar a los grupos de riesgo. (AU)

Objetives: It is not clear whether diet in the Spanish general population is also a relevant determinant of hypovitaminosis D. The objective of the study was to analyze the impact of diet on the prevalence of hypovitaminosis D in healthy children. Methods: Demographic, anthropometric, nutritional, analytical data and vitamin D (25 (OH) D) level were studied using an enzyme-immuno-analysis using an observational design in a sample of the pediatric population between 4 and 14 years old. The 24-hour reminder diet survey was evaluated with the DietSource 3.0 software. The probability of hypovitaminosis was analyzed using logistic regression. Results: 280 healthy children with a mean age of 9.0 years were recruited. The prevalence of hypovitaminosis D (<20 ng/ml) was 18.15% and that of severe deficit (<10 ng/ml) 1.4%. Ethnicity, seasonality, skin phototype, and time of sun exposure were significantly associated with the presence of hypovitaminosis D. The distribution of nutrients did not show differences between the groups with and without hypovitaminosis except for Pyridoxine B6 and saturated fatty acids. Conclusions: Diet plays a reduced role as a risk factor for hypovitaminosis D in healthy children and the relevant factors are those related to sun exposure. An adequate outdoor lifestyle, sun exposure free of sunscreens and dietary patterns that ensure a correct intake of vitamin D and calcium remain the ideal recommendations for the general population. Supplementation should be limited to risk groups. (AU)

Validez de un registro poblacional automatizado de demencia basado en las bases de datos clínicas / Validity of a computerized population registry of dementia based on clinical databases

Introducción: El manejo de la información mediante soportes digitales permite abordajes innovadores de la identificación de los casos de demencia mediante búsquedas automatizadas en las bases de datos clínicas con sistemas de codificación de los diagnósticos. El objetivo de este trabajo fue analizar la validez de un registro de demencia en Gipuzkoa basado en los sistemas de registro administrativos y clínicos existentes en el Servicio Vasco de Salud.MétodosEs un estudio descriptivo basado en la evaluación de las fuentes de datos disponibles. Primero, mediante revisión de historias clínicas se evaluó la validez diagnóstica en 2 muestras de casos identificados y no identificados como demencia. Se midió la sensibilidad, especificidad y valor predictivo positivo y negativo del diagnóstico de demencia. Posteriormente se buscaron los casos de demencia vivos a fecha 31 de diciembre de 2016 en toda la población guipuzcoana y se recogieron variables sociodemográficas y clínicas.ResultadosLas 2 muestras de validación incluyeron 986 casos y 327 no casos. La sensibilidad calculada fue del 80,2% y la especificidad del 99,9%. El valor predictivo negativo fue del 99,4% y el positivo del 95,1%. Los casos registrados en toda la población guipuzcoana fueron 10.551 que supone un 65% de los casos previstos según la literatura. Un 40% tomaban medicación antisicótica. La población institucionalizada fue del 25%.ConclusionesUn registro de demencias basado en las bases de datos clínicas y administrativas es válido y factible. Su principal aportación es mostrar la dimensión que tiene la demencia en el ámbito del sistema sanitario. (AU)

Introduction: The handling of information through digital media allows innovative approaches for identifying cases of dementia through computerized searches within the clinical databases that include systems for coding diagnoses. The aim of this study was to analyze the validity of a dementia registry in Gipuzkoa based on the administrative and clinical databases existing in the Basque Health Service.MethodsThis is a descriptive study based on the evaluation of available data sources. First, through review of medical records, the diagnostic validity was evaluated in 2 samples of cases identified and not identified as dementia. The sensitivity, specificity and positive and negative predictive value of the diagnosis of dementia were measured. Subsequently, the cases of living dementia in December 31, 2016 were searched in the entire Gipuzkoa population to collect sociodemographic and clinical variables.ResultsThe validation samples included 986 cases and 327 no cases. The calculated sensitivity was 80.2% and the specificity was 99.9%. The negative predictive value was 99.4% and positive value was 95.1%. The cases in Gipuzkoa were 10,551, representing 65% of the cases predicted according to the literature. Antipsychotic medication were taken by a 40% and a 25% of the cases were institutionalized.ConclusionsA registry of dementias based on clinical and administrative databases is valid and feasible. Its main contribution is to show the dimension of dementia in the health system. (AU)

Validity of a computerised population registry of dementia based on clinical databases.

INTRODUCTION: The handling of information through digital media allows innovative approaches for identifying cases of dementia through computerised searches within the clinical databases that include systems for coding diagnoses. The aim of this study was to analyse the validity of a dementia registry in Gipuzkoa based on the administrative and clinical databases existing in the Basque Health Service. METHODS: This is a descriptive study based on the evaluation of available data sources. First, through review of medical records, the diagnostic validity was evaluated in two samples of cases identified and not identified as dementia. The sensitivity, specificity and positive and negative predictive value of the diagnosis of dementia were measured. Subsequently, the cases of living dementia in December 31, 2016 were searched in the entire Gipuzkoa population to collect sociodemographic and clinical variables. RESULTS: The validation samples included 986 cases and 327 no cases. The calculated sensitivity was 80.2% and the specificity was 99.9%. The negative predictive value was 99.4% and positive value was 95.1%. The cases in Gipuzkoa were 10 551, representing 65% of the cases predicted according to the literature. Antipsychotic medication were taken by a 40% and a 25% of the cases were institutionalised. CONCLUSIONS: A registry of dementias based on clinical and administrative databases is valid and feasible. Its main contribution is to show the dimension of dementia in the health system.

Evaluation of the colorectal cancer screening Programme in the Basque Country (Spain) and its effectiveness based on the Miscan-colon model.

The population-based Basque Colorectal Cancer (CRC) Screening Programme started in 2009 with a biennial immunochemical quantitative test (FIT) biennial and colonoscopy under sedation in positive cases. The population target of 586,700 residents was from 50 to 69 years old and the total coverage was reached at the beginning of 2014. The aim of our study was to determine possible scenarios in terms of incidence, mortality and reduction of Life-years-Lost (L-y-L) in the medium and long term of CRC. METHODS: Invitations were sent out by the Programme from 2009 to 2014, with combined organizational strategies. Simulation was done by MISCAN-colon (Microsimulation Screening Analysis) over 30 years comparing the results of screening vs no-screening, taking the population-based Cancer Registry into account. Lifetime population and real data from the Programme were used from 2008 to 2012. The model was run differentially for men and women. RESULTS: 924,416 invitations were sent out from 2009 to 2014. The average participation rate was 68.4%, CRC detection rate was 3.4% and the Advanced Adenoma detection rate was 24.0‰, with differences observed in sex and age. Future scenarios showed a higher decrease of incidence (17.2% vs 14.7%), mortality (28.1% vs 22.4%) and L-y-L (22.6% vs 18.4%) in men than women in 2030. CONCLUSIONS: The Basque Country CRC Programme results are aligned to its strategy and comparable to other programmes. MISCAN model was found to be a useful tool to predict the benefits of the programme in the future. The effectiveness of the Programme has not been formally established as case control studies are required to determine long term benefits from the screening strategy.

Supervivencia del cáncer de próstata avanzado en España según escala de Gleason, edad y estadio / Advanced prostate cancer survival in Spain according to the Gleason score, age and stage

Objetivos: El objetivo de este estudio fue estimar la supervivencia global y desagregada en función de la escala de Gleason, de la edad y del tipo de extensión de una cohorte de pacientes con diagnóstico de cáncer de próstata avanzado de acuerdo a la práctica clínica habitual. Material y método: Se utilizó un diseño de estudio observacional y retrospectivo. En cada paciente se registraron variables clínicas como el tipo de extensión (metastásico o localmente avanzado), escala de Gleason, edad, fecha de diagnóstico, fecha del último contacto con el sistema de salud y el estado vital en el último contacto. Se utilizaron técnicas estadísticas de supervivencia de tipo univariante y multivariante. Los métodos de supervivencia paramétrica permitieron calcular la supervivencia media mediante extrapolación. Se analizaron 219 pacientes atendidos en el sistema de salud público entre 2008 y 2011. El análisis mostró diferencias estadísticamente significativas en la supervivencia en función de la escala de Gleason, la edad y el estadio. La supervivencia mayor se dio en el subgrupo menor de 75 años, con extensión local y categoría de bajo riesgo en la escala de Gleason (19,41 años) y la menor en el subgrupo opuesto, que fue de 0,97 años. La supervivencia de los otros subgrupos se movió entre esos valores extremos. Conclusión: La principal aportación de este trabajo consiste en calcular por primera vez la supervivencia media del CPA en España en relación con las variables de nuestra población de estudio. Esta información permite al clínico predecir la esperanza de vida de cada paciente según sus factores pronósticos

Objectives: The aim of this study was to determine the overall and disaggregated survival based on the Gleason score, age and extent of a patient cohort diagnosed with advanced prostate cancer according to standard clinical practice. Material and method: We used an observational and retrospective design for the study. For each patient, we recorded clinical variables such as the extent (metastatic or locally advanced), Gleason score, age, date of diagnosis, date of last contact with the health system and the vital status during the last contact. We used univariate and multivariate statistical techniques of survival. The parametric survival methods enabled us to calculate the mean survival using extrapolation. We analysed 219 patients treated in the public health system between 2008 and 2011. The analysis showed statistically significant differences in survival depending on Gleason score, age and stage. The longest survival was in the subgroup younger than 75 years, with a local extent and a low-risk category on the Gleason scale (19.41 years), and the shortest survival (0.97 years) was in the 75 years or older group. The survival of the other subgroups ranged between these outliers. Conclusion: The main contribution of this study is that it is the first to calculate the mean survival of advanced prostate cancer in Spain in terms of the variables of our study population. This information helps clinicians predict the life expectancy of each patient according to their prognostic factors

Advanced prostate cancer survival in Spain according to the Gleason score, age and stage. / Supervivencia del cáncer de próstata avanzado en España según escala de Gleason, edad y estadio.

OBJECTIVES: The aim of this study was to determine the overall and disaggregated survival based on the Gleason score, age and extent of a patient cohort diagnosed with advanced prostate cancer according to standard clinical practice. MATERIAL AND METHOD: We used an observational and retrospective design for the study. For each patient, we recorded clinical variables such as the extent (metastatic or locally advanced), Gleason score, age, date of diagnosis, date of last contact with the health system and the vital status during the last contact. We used univariate and multivariate statistical techniques of survival. The parametric survival methods enabled us to calculate the mean survival using extrapolation. We analysed 219 patients treated in the public health system between 2008 and 2011. The analysis showed statistically significant differences in survival depending on Gleason score, age and stage. The longest survival was in the subgroup younger than 75 years, with a local extent and a low-risk category on the Gleason scale (19.41 years), and the shortest survival (0.97 years) was in the 75 years or older group. The survival of the other subgroups ranged between these outliers. CONCLUSION: The main contribution of this study is that it is the first to calculate the mean survival of advanced prostate cancer in Spain in terms of the variables of our study population. This information helps clinicians predict the life expectancy of each patient according to their prognostic factors.

Regional variability in changes in the incidence of hip fracture in the Spanish population (2000-2012).

UNLABELLED: The objective is to analyse the evolution of the incidence of hip fracture in the female population of Spain from 2000 to 2012 and to establish the possible changes which may have been seen over this period of time, including the trends in the different regions of the country. INTRODUCTION: Fragility-related hip fractures are considered to be the fractures of greatest significance to public health due to their high degree of morbidity and mortality. The change in their incidence, both in absolute values and when adjusted for age, is the subject of debate. The objective of this article is to describe the changes in the rates of hip fracture in Spain by autonomous community between the years 2000 and 2012. METHODS: Using the data from the Spanish Minimum Basic Data Set, in which are all the recorded cases of women with a principal diagnosis of hip fracture, the incidence rates by age group and by autonomous community were obtained. Poisson distribution or negative binomial regressions were carried out to estimate the average annual change over the time period analysed. RESULTS: There have been statistically significant changes in the trends of rates of incidence for all age groups of women over 65 years of age. The annual reduction was 2.2% for women of 65-74 years of age and less for those between 75 and 84. The rates of incidence for those over 85 increased annually by 0.58%. CONCLUSIONS: Hip fractures continue to increase in absolute numbers, although if the rates are adjusted for age, a downward trend is seen in certain age groups. These findings have various origins, although in the absence of great changes in population structure, we believe that drug treatments for osteoporosis may play a role. There is variability in the change in incidence of hip fractures in different parts of the country. Further studies are required to be able to identify the causes.

[Cost-analysis of viscosupplementation treatment with hyaluronic acid in candidate knee replacement patients with osteoarhritis]. / Análisis de costes del tratamiento con viscosuplementación con ácido hialurónico estabilizado en pacientes con artrosis de rodilla candidatos a implantación de prótesis.

A high percentage of knee osteoarthritis finally need a knee replacement. Previous treatments used including viscosupplementation with hyaluronic acid can delay the knee replacement. The objective of this study was to estimate the economic impact in the short, medium and long term of the knee replacement delay, by conducting a budget impact analysis of the incorporation of viscosupplementation to the treatment of knee osteoarthritis. From the data of patients treated at a specialized Knee Osteoarthritis Unit we built a discrete event simulation model that reproduced the progress of patients, as it could represent changes in the health status of an individual and their interaction with the system. The model allowed the number of prostheses and replacements performed each year to be calculated in a population including 1,000 patients each year according to the use of viscosupplementation. The budget impact analysis was estimated for 10 years by adding the cost of each treatment. A total of 224 patient candidates to receive a knee replacement were studied. The viscosupplementation use delayed the need to perform the knee replacement by 2.67 years The budgetary impact would lead to net savings during the 10 years. However, it is much greater in the earlier years. The sum of the savings in the first three years would be 36 million euros. The study concludes that the use of viscosupplementation reduced the economic burden of knee osteoarthritis in the health system as a result of delayed knee replacement. The simulation model enabled the economic impact in both the short and long term to be analysed.

Análisis de costes del tratamiento con viscosuplementación con ácido hialurónico estabilizado en pacientes con artrosis de rodilla candidatos a implantación de prótesis / Cost-analysis of viscosuplementation treatment with hyaluronic acid in candidate knee replacement patients with osteoarhritis

Una gran parte de los pacientes con artrosis de rodilla acaban siendo intervenidos de una prótesis. Los tratamientos previos utilizados, entre ellos la viscosuplementación con ácido hialurónico pueden permitir retrasar esta evolución, lo que conlleva un impacto económico a corto, medio y largo plazo. El objetivo de este estudio es estimar el análisis del impacto presupuestario de la incorporación de la viscosuplementación. A partir de un estudio retrospectivo de pacientes tratados con viscosuplementación se construyó un modelo de simulación de eventos discretos que reprodujo la evolución de los pacientes, ya que permite representar cambios en el estado de salud de un individuo y su interacción con el sistema. El modelo permitió calcular el número de prótesis y recambios efectuados cada año, en una población que cada año incorpora 1.000 pacientes. Añadiendo los costes de cada uno de los tratamientos aplicados se estimó el análisis del impacto presupuestario. Se estudiaron 224 pacientes. El uso de viscosuplementación retrasó 2,67 años la necesidad de implantación de la prótesis. Al analizar el impacto presupuestario se estimó un ahorro continuado a lo largo del tiempo, que es mucho mayor en los primeros años. Los ahorros de los primeros 3 años fueron de 36 de millones de euros. El uso de la viscosuplementación redujo la carga económica de la artrosis de rodilla en el sistema sanitario como consecuencia del retraso de la implantación de la prótesis. El modelo de simulación permitió analizar conjuntamente el impacto económico a corto y largo plazo (AU)

A high percentage of knee osteoarthritis finally need a knee replacement. Previous treatments used including viscosupplementation with hyaluronic acid can delay the knee replacement. The objective of this study was to estimate the economic impact in the short, medium and long term of the knee replacement delay, by conducting a budget impact analysis of the incorporation of viscosupplementation to the treatment of knee osteoarthritis. From the data of patients treated at a specialized Knee Osteoarthritis Unit we built a discrete event simulation model that reproduced the progress of patients, as it could represent changes in the health status of an individual and their interaction with the system. The model allowed the number of prostheses and replacements performed each year to be calculated in a population including 1,000 patients each year according to the use of viscosupplementation. The budget impact analysis was estimated for 10 years by adding the cost of each treatment. A total of 224 patient candidates to receive a knee replacement were studied. The viscosupplementation use delayed the need to perform the knee replacement by 2.67 years The budgetary impact would lead to net savings during the 10 years. However, it is much greater in the earlier years. The sum of the savings in the first three years would be 36 million euros. The study concludes that the use of viscosupplementation reduced the economic burden of knee osteoarthritis in the health system as a result of delayed knee replacement. The simulation model enabled the economic impact in both the short and long term to be analysed (AU)

Valoración del dolor agudo postoperatorio / Assessment of acute postoperative pain

Objetivo: Una tarea de la enfermería es vigilar que el dolor asociado a las intervenciones quirúrgicas no altere el bienestar del paciente. El primer objetivo de este estudio es medir el grado de satisfacción de los pacientes operados respecto al control del dolor postoperatorio. En segundo lugar, se pretende conocer los factores que determinan una analgesia postoperatoria adecuada y evaluar el valor predictivo de la escala visual analógica (EVA). Material y métodos: A una muestra de pacientes intervenidos se les pasó la EVA a las 2 h y el cuestionario de la Sociedad Americana del Dolor a las 24h. Se utilizó la curva de eficacia diagnóstica para determinar un punto de corte en la EVA como prueba diagnóstica, y los modelos de regresión logística para determinar la contribución de cada una de las variables. Resultados: Se entrevistaron 237 pacientes entre abril de 2007 y abril de 2008. El 54% de los intervenidos refirió dolor. El 98% de los pacientes estuvo satisfecho con su manejo y el 95% creyó que los analgésicos pueden aliviar el dolor mucho o totalmente. Las variables que se asociaron significativamente a la presencia de dolor fueron la especialidad y una EVA superior a 0. Este punto de corte en la EVA fue el que aportó mejores resultados diagnósticos. Conclusiones: El control del dolor postoperatorio se lleva a cabo de forma satisfactoria. El uso de la EVA a las 2h de la intervención permite identificar una parte importante de los pacientes que van a tener dolor (AU)

Objective: A nursing task is to look after the pain associated with surgical procedures in order to maintain patient wellbeing. The first objective of this study was to measure the level of the patient satisfaction with management of post-operative pain. Secondly, we wanted to identify the determining factors of an adequate postoperative analgesia and the predictive value of the visual analogical scale (VAS). Material and methods: A sample of patients who had an operation was interviewed. The VAS was administered two hours and 24h after the surgical procedure with the American Society of Pain questionnaire. ROC curves were applied to establish the cut-off point for the VAS. We determined the contribution of different variables to adequate pain management by means of logistic regression. Results: We interviewed 237 patients in 2007 and 2008. Pain during the first 24h was perceived by 54% of them, 98% were satisfied with pain management and 95% expressed that analgesic treatment relieved their pain. Variables statistically associated with pain were specialty, and a value on the VAS higher than 0 two hours after the procedure. Conclusions: The management of post operative pain is satisfactory. The use of the VAS during the first two hours identifies an important percentage of patients who require more intensive analgesic treatment (AU)

[Assessment of acute postoperative pain]. / Valoración del dolor agudo postoperatorio.

OBJECTIVE: A nursing task is to look after the pain associated with surgical procedures in order to maintain patient wellbeing. The first objective of this study was to measure the level of the patient satisfaction with management of post-operative pain. Secondly, we wanted to identify the determining factors of an adequate postoperative analgesia and the predictive value of the visual analogical scale (VAS). MATERIAL AND METHODS: A sample of patients who had an operation was interviewed. The VAS was administered two hours and 24h after the surgical procedure with the American Society of Pain questionnaire. ROC curves were applied to establish the cut-off point for the VAS. We determined the contribution of different variables to adequate pain management by means of logistic regression. RESULTS: We interviewed 237 patients in 2007 and 2008. Pain during the first 24h was perceived by 54% of them, 98% were satisfied with pain management and 95% expressed that analgesic treatment relieved their pain. Variables statistically associated with pain were specialty, and a value on the VAS higher than 0 two hours after the procedure. CONCLUSIONS: The management of post operative pain is satisfactory. The use of the VAS during the first two hours identifies an important percentage of patients who require more intensive analgesic treatment.