ABSTRACT
Trigger fingers are common. Although the options for management are well-described, including conservative measures such as steroid injection, or surgical options such as open or percutaneous release, there remains variations in the way these are administered. In addition, there is a recent emphasis on patient-reported outcome measures in this condition. The purpose of this further knowledge article is to look at three recently published articles to gather some evidence about best practice in the management of this painful but common condition.
ABSTRACT
We sought to identify national trends in tool and machinery-related hand injuries. Hospital Episodes Statistics data in England from 1998 to 2017 were analysed. Data from our hand unit from 2011 to 2017 were also reviewed to establish the types of tool and machinery causing injury. During the 19-year study period 210,291 admissions occurred as a result of tool and machinery-related injuries. The overall incidence rate and mean age increased. The largest increase in incidence rate was in the oldest age group (75 years+). The incidence rate in children fell. During the period studied, 2150 patients underwent surgery in our unit for tool and machinery-related injuries. The hand was involved in 2069 (96%) of the injuries. Adult injuries were caused by a similar proportion of types of tool or machinery in all age groups. This study demonstrates a clear and sustained trend of increasing incidence of tool and machinery-related injuries in adults. The largest increase is in older patients.Level of evidence: IV.
Subject(s)
Hand Injuries , Adult , Aged , Child , England/epidemiology , Hand Injuries/epidemiology , Hand Injuries/etiology , Hospitalization , Hospitals , Humans , IncidenceABSTRACT
LEVEL OF EVIDENCE: III.
Subject(s)
Closed Fracture Reduction , Finger Injuries/therapy , Finger Joint/surgery , Fracture Dislocation/therapy , Fracture Fixation, Internal , Arthritis/etiology , Closed Fracture Reduction/adverse effects , Finger Injuries/complications , Finger Injuries/surgery , Fracture Dislocation/surgery , Fracture Fixation, Internal/adverse effects , HumansSubject(s)
Forearm Injuries/therapy , Muscle, Skeletal/injuries , Tendon Injuries/therapy , Weight Lifting/injuries , Adult , Female , Forearm Injuries/diagnostic imaging , Forearm Injuries/etiology , Humans , Muscle, Skeletal/diagnostic imaging , Rupture , Tendon Injuries/diagnostic imaging , Tendon Injuries/etiology , UltrasonographyABSTRACT
Carboxylic acids derived from the amido groups of the antitumor agents mitozolomide and temozolomide have been conjugated to simple amino acids and peptides by carbodiimide coupling. Solid-state peptide synthesis has been applied to link the acids to DNA major groove-binding peptidic motifs known to adopt alpha-helical conformations. Attachment of the acids to pyrrole and imidazole polyamidic lexitropsins gave a series of potential DNA minor groove-binding ligands. In vitro biological evaluation of a limited number of these novel conjugates failed to demonstrate any enhanced growth-inhibitory activity compared to the unconjugated drugs; sites of alkylation at tracts of multiple guanines were also unaffected. Attachment of additional residues at C-8 of the imidazotetrazines did not perturb the chemistry of activation of the bicyclic nucleus, and biological sequelae can be rationalized by invoking the liberation of a common, diffusible, reactive chemical intermediate, the methanediazonium ion.
